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01.12.2012 | Research | Ausgabe 1/2012 Open Access

World Journal of Surgical Oncology 1/2012

Pattern of distant recurrence according to the molecular subtypes in Korean women with breast cancer

World Journal of Surgical Oncology > Ausgabe 1/2012
Hyung Seok Park, Shinhyuk Kim, Kiho Kim, Ho Yoo, Byung Joo Chae, Ja Seong Bae, Byung Joo Song, Sang Seol Jung
Wichtige Hinweise

Electronic supplementary material

The online version of this article (doi:10.​1186/​1477-7819-10-4) contains supplementary material, which is available to authorized users.

Competing interests

The authors declare that they have no competing interests.

Authors' contributions

HSP contributed mainly in the design, literature review and writing of the article. Collection and assembly of the data was performed by BJC and HSP. BJS provided the idea, planned, edited and approved the written work. SK, KK, HY, BJC, JSB, and SSJ gave valuable advices and edited the discussion. Both BJS and SSJ also provided administrative supports. All authors read and approved the manuscript.



Distant recurrence is one of the most important risk factors in overall survival, and distant recurrence is related to a complex biologic interaction of seed and soil factors. The aim of the study was to investigate the association between the molecular subtypes and patterns of distant recurrence in patients with breast cancer.


In an investigation of 313 women with breast cancer who underwent surgery from 1994 and 2000, the expressions of estrogen and progestrone receptor (ER/PR), and human epithelial receptor-2 (HER2) were evaluated. The subtypes were defined as luminal-A, luminal-HER2, HER2-enriched, and triple negative breast cancer (TNBC) according to ER, PR, and HER2 status.


Bone was the most common site of distant recurrence. The incidence of first distant recurrence site was significantly different among the subtypes. Brain metastasis was more frequent in the luminal-HER2 and TNBC subtypes. In subgroup analysis, overall survival in patients with distant recurrence after 24 months after surgery was significantly different among the subtypes.


Organ-specific metastasis may depend on the molecular subtype of breast cancer. Tailored strategies against distant metastasis concerning the molecular subtypes in breast cancer may be considered.
Authors’ original file for figure 1
Authors’ original file for figure 2
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