Erschienen in:
01.06.2007 | Case Report
Pericentral Liver Cell Necrosis Associated with the Use of High-Dose Intravenous Methylprednisolone
verfasst von:
Hannah M. Lee, Jeremy S. Ditelberg, Marshall M. Kaplan
Erschienen in:
Digestive Diseases and Sciences
|
Ausgabe 6/2007
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Excerpt
Glucocorticoids are one of the few (classes of) drugs that have not been associated with hepatic injury. Glucocorticoids are widely used to treat a variety of diseases, usually immunologically mediated, including autoimmune chronic hepatitis. Although their long-term use is associated with a wide variety of unwanted side effects, liver disease is not one of them. We now describe a patient who developed acute central hepatic necrosis while receiving high-dose intravenous methylprednisolone. His liver disease remitted after methylprednisolone was stopped. The temporal relationship between the central hepatic necrosis and the use of high-dose intravenous methylprednisolone suggests that methylprednisolone was the cause. …