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Annals of Hematology

Erschienen in:

01.04.2005 | Original Article

Pericentric chromosome 8 inversion associated with the 5′RUNX1/3′CBFA2T1 gene in acute myeloid leukemia cases

verfasst von: L. Anelli, F. Albano, A. Zagaria, A. Liso, A. Cuneo, M. Mancini, V. Liso, M. Rocchi, G. Specchia

Erschienen in: Annals of Hematology | Ausgabe 4/2005

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Abstract

In the present paper we report pericentric chromosome 8 inversions in two (2.4%) of 82 acute myeloid leukemia (AML) cases characterized by the 5′RUNX1/3′CBFA2T1 fusion gene. Molecular cytogenetic characterization was achieved using appropriate bacterial artificial chromosome (BAC) and P1 artificial chromosome (PAC) probes in fluorescence in situ hybridization (FISH) experiments. In these two cases the fusion gene was detected on the der(8) short arm, resulting from a pericentric chromosome 8 inversion followed by a t(8;21) rearrangement. These results suggest that heterogeneous mechanisms can lead to the generation of the 5′RUNX1/3′CBFA2T1chimeric gene.

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Titel: Pericentric chromosome 8 inversion associated with the 5′RUNX1/3′CBFA2T1 gene in acute myeloid leukemia cases
verfasst von: L. Anelli
F. Albano
A. Zagaria
A. Liso
A. Cuneo
M. Mancini
V. Liso
M. Rocchi
G. Specchia
Publikationsdatum: 01.04.2005
Verlag: Springer-Verlag
Erschienen in: Annals of Hematology / Ausgabe 4/2005
Print ISSN: 0939-5555
Elektronische ISSN: 1432-0584
DOI: https://doi.org/10.1007/s00277-004-0960-x

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Pericentric chromosome 8 inversion associated with the 5′RUNX1/3′CBFA2T1 gene in acute myeloid leukemia cases

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