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Erschienen in: Current Anesthesiology Reports 2/2018

01.06.2018 | Geriatric Anesthesia (S Akhtar, Section Editor)

Perioperative Outcome in Geriatric Patients

verfasst von: Shamsuddin Akhtar

Erschienen in: Current Anesthesiology Reports | Ausgabe 2/2018

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Abstract

Purpose of Review

Increasing number of very old patients (> 80 year old) are presenting for invasive procedures and surgeries. This review addresses perioperative outcomes after cardiac and non-cardiac surgery, in octogenarians and older patients.

Recent Findings

The overall rates of major upper abdominal cancer resections in octogenarians are increasing over time. Postoperative mortality, postoperative admission to the intensive care unit, and discharge to non-home disposition, after emergency general surgery, were strongly associated with age greater than 80 years. Though acceptable, perioperative morbidity and mortality tends to increase non-linearly after the age of 75 years in patients undergoing cardiac operations.

Summary

Clinician-centric outcomes continue to dominate outcome reporting. Octogenarians have higher risk of mortality and increased rates of complications, both after cardiac and non-cardiac surgeries. Perioperative care is more resource intensive in the elderly. It is important to keep these factors in mind when contemplating interventions in very elderly individuals.
Literatur
1.
Zurück zum Zitat Chow WB, Rosenthal RA, Merkow RP, Ko CY, Esnaola NF, American College of Surgeons National Surgical Quality Improvement P, et al. Optimal preoperative assessment of the geriatric surgical patient: a best practices guideline from the American College of Surgeons National Surgical Quality Improvement Program and the American Geriatrics Society. J Am Coll Surg. 2012;215:453–66.CrossRef Chow WB, Rosenthal RA, Merkow RP, Ko CY, Esnaola NF, American College of Surgeons National Surgical Quality Improvement P, et al. Optimal preoperative assessment of the geriatric surgical patient: a best practices guideline from the American College of Surgeons National Surgical Quality Improvement Program and the American Geriatrics Society. J Am Coll Surg. 2012;215:453–66.CrossRef
2.
Zurück zum Zitat McIsaac DI, Moloo H, Bryson GL, van Walraven C. The association of frailty with outcomes and resource use after emergency general surgery: a population-based cohort study. Anesth Analg. 2017;124:1653–61.CrossRef McIsaac DI, Moloo H, Bryson GL, van Walraven C. The association of frailty with outcomes and resource use after emergency general surgery: a population-based cohort study. Anesth Analg. 2017;124:1653–61.CrossRef
3.
Zurück zum Zitat Brown CH, Max L, LaFlam A, Kirk L, Gross A, Arora R, et al. The association between preoperative frailty and postoperative delirium after cardiac surgery. Anesth Analg. 2016;123:430–5.CrossRef Brown CH, Max L, LaFlam A, Kirk L, Gross A, Arora R, et al. The association between preoperative frailty and postoperative delirium after cardiac surgery. Anesth Analg. 2016;123:430–5.CrossRef
4.
Zurück zum Zitat Lin HS, Watts JN, Peel NM, Hubbard RE. Frailty and post-operative outcomes in older surgical patients: a systematic review. BMC Geriatr. 2016;16:157.CrossRef Lin HS, Watts JN, Peel NM, Hubbard RE. Frailty and post-operative outcomes in older surgical patients: a systematic review. BMC Geriatr. 2016;16:157.CrossRef
5.
Zurück zum Zitat Barnett SR. Polypharmacy and perioperative medications in the elderly. Anesthesiol Clin. 2009;27:377–89. table of contentsCrossRef Barnett SR. Polypharmacy and perioperative medications in the elderly. Anesthesiol Clin. 2009;27:377–89. table of contentsCrossRef
6.
Zurück zum Zitat Richardson JD, Cocanour CS, Kern JA, Garrison RN, Kirton OC, Cofer JB, et al. Perioperative risk assessment in elderly and high-risk patients. J Am Coll Surg. 2004;199:133–46.CrossRef Richardson JD, Cocanour CS, Kern JA, Garrison RN, Kirton OC, Cofer JB, et al. Perioperative risk assessment in elderly and high-risk patients. J Am Coll Surg. 2004;199:133–46.CrossRef
7.
Zurück zum Zitat Kwok AC, Semel ME, Lipsitz SR, Bader AM, Barnato AE, Gawande AA, et al. The intensity and variation of surgical care at the end of life: a retrospective cohort study. Lancet. 2011;378:1408–13.CrossRef Kwok AC, Semel ME, Lipsitz SR, Bader AM, Barnato AE, Gawande AA, et al. The intensity and variation of surgical care at the end of life: a retrospective cohort study. Lancet. 2011;378:1408–13.CrossRef
8.
Zurück zum Zitat Bagshaw SM, Webb SA, Delaney A, George C, Pilcher D, Hart GK, et al. Very old patients admitted to intensive care in Australia and New Zealand: a multi-centre cohort analysis. Crit Care (Lond). 2009;13:R45.CrossRef Bagshaw SM, Webb SA, Delaney A, George C, Pilcher D, Hart GK, et al. Very old patients admitted to intensive care in Australia and New Zealand: a multi-centre cohort analysis. Crit Care (Lond). 2009;13:R45.CrossRef
9.
Zurück zum Zitat Bowyer A, Royse C. The importance of postoperative quality of recovery: influences, assessment, and clinical and prognostic implications. Can J Anaesth. 2016;63:176–83.CrossRef Bowyer A, Royse C. The importance of postoperative quality of recovery: influences, assessment, and clinical and prognostic implications. Can J Anaesth. 2016;63:176–83.CrossRef
10.
Zurück zum Zitat Royse CF, Newman S, Chung F, Stygall J, McKay RE, Boldt J, et al. Development and feasibility of a scale to assess postoperative recovery: the post-operative quality recovery scale. Anesthesiology. 2010;113:892–905.CrossRef Royse CF, Newman S, Chung F, Stygall J, McKay RE, Boldt J, et al. Development and feasibility of a scale to assess postoperative recovery: the post-operative quality recovery scale. Anesthesiology. 2010;113:892–905.CrossRef
11.
Zurück zum Zitat •• Bowyer AJ, Royse CF. Postoperative recovery and outcomes—what are we measuring and for whom? Anaesthesia. 2016;71(Suppl 1):72–7. The article describes new ways of looking at outcomes and how different outcomes may be relevant for different individuals.CrossRef •• Bowyer AJ, Royse CF. Postoperative recovery and outcomes—what are we measuring and for whom? Anaesthesia. 2016;71(Suppl 1):72–7. The article describes new ways of looking at outcomes and how different outcomes may be relevant for different individuals.CrossRef
12.
Zurück zum Zitat Paddison JS, Sammour T, Kahokehr A, Zargar-Shoshtari K, Hill AG. Development and validation of the Surgical Recovery Scale (SRS). J Surg Res. 2011;167:e85–91.CrossRef Paddison JS, Sammour T, Kahokehr A, Zargar-Shoshtari K, Hill AG. Development and validation of the Surgical Recovery Scale (SRS). J Surg Res. 2011;167:e85–91.CrossRef
13.
Zurück zum Zitat St-Louis E, Sudarshan M, Al-Habboubi M, El-Husseini Hassan M, Deckelbaum DL, Razek TS, et al. The outcomes of the elderly in acute care general surgery. Eur J Trauma Emerg Surg. 2016;42:107–13.CrossRef St-Louis E, Sudarshan M, Al-Habboubi M, El-Husseini Hassan M, Deckelbaum DL, Razek TS, et al. The outcomes of the elderly in acute care general surgery. Eur J Trauma Emerg Surg. 2016;42:107–13.CrossRef
14.
Zurück zum Zitat Pirrera B, Lucchi A, Gabbianelli C, Alagna V, Martorelli G, Berti P, et al. E.R.A.S. pathway in colorectal surgery in elderly: our experience: a retrospective cohort study. Int J Surg. 2017;43:101–6.CrossRef Pirrera B, Lucchi A, Gabbianelli C, Alagna V, Martorelli G, Berti P, et al. E.R.A.S. pathway in colorectal surgery in elderly: our experience: a retrospective cohort study. Int J Surg. 2017;43:101–6.CrossRef
15.
Zurück zum Zitat Duraes LC, Stocchi L, Dietz D, Kalady MF, Kessler H, Schroeder D, et al. The disproportionate effect of perioperative complications on mortality within 1 year after colorectal cancer resection in octogenarians. Ann Surg Oncol. 2016;23:4293–301.CrossRef Duraes LC, Stocchi L, Dietz D, Kalady MF, Kessler H, Schroeder D, et al. The disproportionate effect of perioperative complications on mortality within 1 year after colorectal cancer resection in octogenarians. Ann Surg Oncol. 2016;23:4293–301.CrossRef
16.
Zurück zum Zitat Antoniou SA, Antoniou GA, Koch OO, Pointner R, Granderath FA. Laparoscopic colorectal surgery confers lower mortality in the elderly: a systematic review and meta-analysis of 66,483 patients. Surg Endosc. 2015;29:322–33.CrossRef Antoniou SA, Antoniou GA, Koch OO, Pointner R, Granderath FA. Laparoscopic colorectal surgery confers lower mortality in the elderly: a systematic review and meta-analysis of 66,483 patients. Surg Endosc. 2015;29:322–33.CrossRef
17.
Zurück zum Zitat Neuwirth MG, Bierema C, Sinnamon AJ, Fraker DL, Kelz RR, Roses RE, Karakousis GC. Trends in major upper abdominal surgery for cancer in octogenarians: has there been a change in patient selection? Cancer. 2018;124(1):125–135. Neuwirth MG, Bierema C, Sinnamon AJ, Fraker DL, Kelz RR, Roses RE, Karakousis GC. Trends in major upper abdominal surgery for cancer in octogenarians: has there been a change in patient selection? Cancer. 2018;124(1):125–135.
18.
Zurück zum Zitat Paulus E, Ripat C, Koshenkov V, Prescott AT, Sethi K, Stuart H, et al. Esophagectomy for cancer in octogenarians: should we do it? Langenbeck's Arch Surg. 2017;402:539–45.CrossRef Paulus E, Ripat C, Koshenkov V, Prescott AT, Sethi K, Stuart H, et al. Esophagectomy for cancer in octogenarians: should we do it? Langenbeck's Arch Surg. 2017;402:539–45.CrossRef
19.
Zurück zum Zitat Liang DH, Shirkey BA, Rosenberg WR, Martinez S. Clinical outcomes of pancreaticoduodenectomy in octogenarians: a surgeon's experience from 2007 to 2015. J Gastrointest Oncol. 2016;7:540–6.CrossRef Liang DH, Shirkey BA, Rosenberg WR, Martinez S. Clinical outcomes of pancreaticoduodenectomy in octogenarians: a surgeon's experience from 2007 to 2015. J Gastrointest Oncol. 2016;7:540–6.CrossRef
20.
Zurück zum Zitat • Mahdi H, Wiechert A, Lockhart D, Rose PG. Impact of age on 30-day mortality and morbidity in patients undergoing surgery for ovarian cancer. Int J Gynecol Cancer. 2015;25:1216–23. The article describes outcomes in elderly gynaecological oncology patients, who tend to have much poorer outcomes that in their younger counterparts.CrossRef • Mahdi H, Wiechert A, Lockhart D, Rose PG. Impact of age on 30-day mortality and morbidity in patients undergoing surgery for ovarian cancer. Int J Gynecol Cancer. 2015;25:1216–23. The article describes outcomes in elderly gynaecological oncology patients, who tend to have much poorer outcomes that in their younger counterparts.CrossRef
21.
Zurück zum Zitat Mihailidis HG, Manners S, Churilov L, Quan GMY. Is spinal surgery safe in octogenarians? ANZ J Surg. 2017;87:605–9.CrossRef Mihailidis HG, Manners S, Churilov L, Quan GMY. Is spinal surgery safe in octogenarians? ANZ J Surg. 2017;87:605–9.CrossRef
22.
Zurück zum Zitat Millstone DB, Perruccio AV, Badley EM, Rampersaud YR. Factors associated with adverse events in inpatient elective spine, knee, and hip orthopaedic surgery. J Bone Joint Surg Am. 2017;99:1365–72.CrossRef Millstone DB, Perruccio AV, Badley EM, Rampersaud YR. Factors associated with adverse events in inpatient elective spine, knee, and hip orthopaedic surgery. J Bone Joint Surg Am. 2017;99:1365–72.CrossRef
23.
Zurück zum Zitat Malkani AL, Dilworth B, Ong K, Baykal D, Lau E, Mackin TN, et al. High risk of readmission in octogenarians undergoing primary hip arthroplasty. Clin Orthop Relat Res. 2017;475:2878–88.CrossRef Malkani AL, Dilworth B, Ong K, Baykal D, Lau E, Mackin TN, et al. High risk of readmission in octogenarians undergoing primary hip arthroplasty. Clin Orthop Relat Res. 2017;475:2878–88.CrossRef
24.
Zurück zum Zitat Dhall SS, Yue JK, Winkler EA, Mummaneni PV, Manley GT, Tarapore PE. Morbidity and mortality associated with surgery of traumatic C2 fractures in octogenarians. Neurosurgery. 2017;80:854–62.CrossRef Dhall SS, Yue JK, Winkler EA, Mummaneni PV, Manley GT, Tarapore PE. Morbidity and mortality associated with surgery of traumatic C2 fractures in octogenarians. Neurosurgery. 2017;80:854–62.CrossRef
25.
Zurück zum Zitat Liu Y, Wang Z, Xiao W. Risk factors for mortality in elderly patients with hip fractures: a meta-analysis of 18 studies. Aging Clin Exp Res. 2018;30(4):323–330. Liu Y, Wang Z, Xiao W. Risk factors for mortality in elderly patients with hip fractures: a meta-analysis of 18 studies. Aging Clin Exp Res. 2018;30(4):323–330.
26.
Zurück zum Zitat Mozaffarian D, Benjamin EJ, Go AS, Arnett DK, Blaha MJ, Cushman M, et al. Heart disease and stroke statistics—2016 update: a report from the American Heart Association. Circulation. 2016;133:e38–e360.PubMed Mozaffarian D, Benjamin EJ, Go AS, Arnett DK, Blaha MJ, Cushman M, et al. Heart disease and stroke statistics—2016 update: a report from the American Heart Association. Circulation. 2016;133:e38–e360.PubMed
27.
Zurück zum Zitat • Krane M, Voss B, Hiebinger A, Deutsch MA, Wottke M, Hapfelmeier A, et al. Twenty years of cardiac surgery in patients aged 80 years and older: risks and benefits. Ann Thoracic Surg. 2011;91:506–13. A large case series of patients describing outcomes in geraitric patients who underwent cardiac operations. It clearly shows that the outcomes are three to four times worse in octagenarians than in younger patients.CrossRef • Krane M, Voss B, Hiebinger A, Deutsch MA, Wottke M, Hapfelmeier A, et al. Twenty years of cardiac surgery in patients aged 80 years and older: risks and benefits. Ann Thoracic Surg. 2011;91:506–13. A large case series of patients describing outcomes in geraitric patients who underwent cardiac operations. It clearly shows that the outcomes are three to four times worse in octagenarians than in younger patients.CrossRef
28.
Zurück zum Zitat Wang W, Bagshaw SM, Norris CM, Zibdawi R, Zibdawi M, MacArthur R. Association between older age and outcome after cardiac surgery: a population-based cohort study. J Cardiothorac Surg. 2014;9:177.CrossRef Wang W, Bagshaw SM, Norris CM, Zibdawi R, Zibdawi M, MacArthur R. Association between older age and outcome after cardiac surgery: a population-based cohort study. J Cardiothorac Surg. 2014;9:177.CrossRef
29.
Zurück zum Zitat Thorsteinsson K, Fonager K, Merie C, Gislason G, Kober L, Torp-Pedersen C, et al. Age-dependent trends in postoperative mortality and preoperative comorbidity in isolated coronary artery bypass surgery: a nationwide study. Eur J Cardiothorac Surg. 2016;49:391–7.CrossRef Thorsteinsson K, Fonager K, Merie C, Gislason G, Kober L, Torp-Pedersen C, et al. Age-dependent trends in postoperative mortality and preoperative comorbidity in isolated coronary artery bypass surgery: a nationwide study. Eur J Cardiothorac Surg. 2016;49:391–7.CrossRef
30.
Zurück zum Zitat • Afilalo J, Steele R, Manning WJ, Khabbaz KR, Rudski LG, Langlois Y, et al. Derivation and validation of prognosis-based age cutoffs to define elderly in cardiac surgery. Circ Cardiovasc Qual Outcomes. 2016;9:424–31. This article is based on large database and shows poor postoperative outcomes in elderly patients undergoing cardiac sugery.CrossRef • Afilalo J, Steele R, Manning WJ, Khabbaz KR, Rudski LG, Langlois Y, et al. Derivation and validation of prognosis-based age cutoffs to define elderly in cardiac surgery. Circ Cardiovasc Qual Outcomes. 2016;9:424–31. This article is based on large database and shows poor postoperative outcomes in elderly patients undergoing cardiac sugery.CrossRef
31.
Zurück zum Zitat De Bruin JL, Baas AF, Buth J, Prinssen M, Verhoeven ELG, Cuypers PWM, et al. Long-term outcome of open or endovascular repair of abdominal aortic aneurysm. N Engl J Med. 2010;362:1881–9.CrossRef De Bruin JL, Baas AF, Buth J, Prinssen M, Verhoeven ELG, Cuypers PWM, et al. Long-term outcome of open or endovascular repair of abdominal aortic aneurysm. N Engl J Med. 2010;362:1881–9.CrossRef
32.
Zurück zum Zitat • Peterss S, Mansour AM, Zafar MA, Thombre K, Rizzo JA, Ziganshin BA, et al. Elective surgery for ascending aortic aneurysm in the elderly: should there be an age cut-off? Eur J Cardiothorac Surg. 2017;51:965–70. One of the few articles describing outcomes in elderly patients undergoing ascending aortic vascular surgery.CrossRef • Peterss S, Mansour AM, Zafar MA, Thombre K, Rizzo JA, Ziganshin BA, et al. Elective surgery for ascending aortic aneurysm in the elderly: should there be an age cut-off? Eur J Cardiothorac Surg. 2017;51:965–70. One of the few articles describing outcomes in elderly patients undergoing ascending aortic vascular surgery.CrossRef
33.
Zurück zum Zitat Barakat HM, Shahin Y, Barnes R, Chetter I, McCollum P. Outcomes after open repair of ruptured abdominal aortic aneurysms in octogenarians: a 20-year, single-center experience. Ann Vasc Surg. 2014;28:80–6.CrossRef Barakat HM, Shahin Y, Barnes R, Chetter I, McCollum P. Outcomes after open repair of ruptured abdominal aortic aneurysms in octogenarians: a 20-year, single-center experience. Ann Vasc Surg. 2014;28:80–6.CrossRef
34.
Zurück zum Zitat Hughes K, Abdulrahman H, Prendergast T, Rose DA, Ongu'ti S, Tran D, et al. Abdominal aortic aneurysm repair in nonagenarians. Ann Vasc Surg. 2015;29:183–8.CrossRef Hughes K, Abdulrahman H, Prendergast T, Rose DA, Ongu'ti S, Tran D, et al. Abdominal aortic aneurysm repair in nonagenarians. Ann Vasc Surg. 2015;29:183–8.CrossRef
Metadaten
Titel
Perioperative Outcome in Geriatric Patients
verfasst von
Shamsuddin Akhtar
Publikationsdatum
01.06.2018
Verlag
Springer US
Erschienen in
Current Anesthesiology Reports / Ausgabe 2/2018
Elektronische ISSN: 2167-6275
DOI
https://doi.org/10.1007/s40140-018-0267-4

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