In metabolic surgery, hemorrhage is the most common major complication. This study investigated whether peroperative administration of tranexamic acid (TXA) reduced the risk of hemorrhage in patients undergoing laparoscopic sleeve gastrectomy (SG).
Methods
In this double-blind randomized controlled trial, patients undergoing primary SG in a high-volume bariatric hospital were randomized (1:1) to receive 1500-mg TXA or placebo peroperatively. Primary outcome measure was peroperative staple line reinforcement using hemostatic clips. Secondary outcome measures were peroperative fibrin sealant use and blood loss, postoperative hemoglobin, heart rate, pain, major and minor complications, length of hospital stay (LOS), side effects of TXA (i.e., venous thrombotic event (VTE)) and mortality.
Results
In total, 101 patients were analyzed and received TXA (n = 49) or placebo (n = 52). There was no statistically significant difference in hemostatic clip devices used in both groups (69% versus 83%, p = 0.161). TXA administration showed significant positive changes in hemoglobin levels (millimoles per Liter; 0.55 versus 0.80, p = 0.013), in heart rate (beats per minute; -4.6 versus 2.5; p = 0.013), in minor complications (Clavien–Dindo ≤ 2, 2.0% versus 17.3%, p = 0.016), and in mean LOS (hours; 30.8 versus 36.7, p = 0.013). One patient in the placebo-group underwent radiological intervention for postoperative hemorrhage. No VTE or mortality was reported.
Conclusion
This study did not demonstrate a statistically significant difference in use of hemostatic clip devices and major complications after peroperative administration of TXA. However, TXA seems to have positive effects on clinical parameters, minor complications, and LOS in patients undergoing SG, without increasing the risk of VTE. Larger studies are needed to investigate the effect of TXA on postoperative major complications.
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The prevalence of extreme obesity is rising, more metabolic procedures are performed, and more patients are exposed to the risks of peroperative and postoperative complications [1]. In metabolic surgery, prevention of venous thrombotic events (VTE) and prevention of hemorrhage are both challenges to be encountered [2, 3]. Postoperative hemorrhage occurs in 2.0–4.0% of patients undergoing laparoscopic sleeve gastrectomy (SG) [4‐9]. Fast-track metabolic surgery is safe and can lower the risk of VTE, due to early mobilization of the patients [10, 11]. However, when patients are discharged early after surgery, even more in day-care setting, the clinical window to detect hemorrhages is narrow. Therefore, fast track metabolic surgery warrants reduction of hemorrhage. Several factors to prevent hemorrhage, such as staple height, stapler closure time before gastric dissecting, and different techniques of staple line reinforcement (SLR), have been investigated [12]. However, none of these factors significantly reduced the incidence of hemorrhage [7, 13, 14].
In other types of surgery, such as cardiothoracic and orthopedic surgery, tranexamic acid (TXA) has been proven to be effective in reducing hemorrhage. In these studies, administration of TXA was safe, as no increase in VTE was seen in these patients [15‐17]. In metabolic surgery, the effectiveness of TXA has not yet been investigated thoroughly. In a non-randomized study described by Chakravartty et al., less bleeding points and a shorter operation time were seen in 25 patients who received TXA, compared to 25 patients in the control group. The authors concluded that administrating TXA was a simple and economically effective option, as TXA is an inexpensive drug [18]. Klaassen et al. evaluated the benefit of postoperative administration of TXA in 44 patients with hemorrhagic complications. They saw no VTE and no reoperations were required in 40 patients [8].
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The effectiveness of TXA in metabolic surgery has not been investigated in a randomized controlled trial. The aim of the current trial was to investigate if peroperative administration of TXA could reduce the per- and postoperative hemorrhage rates in patients undergoing SG, without increasing the risk of VTE.
Methods
Design and patients
The study protocol has been published previously (supplementary file 1) [19]. In brief, we conducted a double-blind randomized controlled trial in a high-volume bariatric hospital. At the outpatient clinic, the coordinating researcher recruited all patients with sufficient Dutch or English language proficiency who were planned to undergo primary SG and met the international guidelines for metabolic surgery [20]. Exclusion criteria were use of anticoagulants, medical history of VTE (defined as deep vein thrombosis or pulmonary embolism) or hemorrhage, and arterial and/or severe iatrogenic bleeding during surgery. Enrollment stopped in September 2021 when the inclusion target for the study was achieved. This study was registered with the Netherlands Trial Register (NL8029).
To determine postoperative hemoglobin levels, a blood sample (one EDTA tube) was obtained within 1 week preoperatively and at day one postoperatively by venipuncture and analyzed in the hospital’s clinical chemistry laboratory according to standard procedures. In all patients, the same staple devices (ECHELON FLEX™ GST) to dissect the stomach and energy device (Harmonic®) were used, starting always with a golden cartridge (3.0 mm), followed by blue (2.4 mm) and rarely green (3.4 mm). All patients were treated by expert bariatric surgeons. Staple line hemorrhage was checked according to a step-by-step protocol (see supplementary files 1 and 2 [19]). After the greater curvature of the stomach was removed from the abdomen, the patient’s blood pressure was brought back to normotension, and the abdominal pressure was lowered to 12 mmHg. The staple line was inspected when normotension was reached. If blood pumped out of the staple line (active bleeding), hemostatic clips (Ethicon Ligaclip®) were applied. If blood was only oozing (passive bleeding), fibrin sealant was applied. Patients with iatrogenic bleeding from another location than the staple line were excluded from the study. Postoperatively, patients received intravenous administration of NaCl 0.9% (≤ 500 ml per 24 h) and 5000 units (prophylactic) low-molecular weight heparin (LMWH) at 10 PM. If patients were hospitalized longer, they continued daily prophylactic LMWH. Patients never received LMWH preoperatively, as is common in Dutch hospitals [10, 22]. All primary and secondary outcomes were prospectively registered in digital case report forms (Castor EDC). Vital signs were measured at 6 AM before mobilization. When postoperative hemoglobin levels were decreased ≥ 1.5 points or ≥ 1.0 point in the presence of clinical symptoms of hemorrhage (such as lightheaded, fainting, tachycardia), the bariatric surgeon was consulted, additional TXA was prescribed, and extra hemoglobin monitoring was ordered. The abdomen was inspected at day one and one week after surgery for abdominal wall hematoma. If there was a high suspicion of a hemorrhage postoperatively, a CT scan was performed. Adverse events were reported to the medical research ethics committee and the national trial committee. All patients underwent SG as described previously [23].
Outcomes
The primary outcome measure was peroperative hemorrhage defined as SLR using hemostatic clips. Secondary outcome measures were peroperative use of fibrin sealant, blood loss, length of procedure (LOP), postoperative difference in hemoglobin (millimole per liter (mmol/L)), heart rate (beats per minute (bpm)), pain, extra hemoglobin monitoring, major complications due to hemorrhage (scored as Clavien–Dindo ≥ 3, i.e., needing packed red blood cells or surgical/radiological intervention ≤ 30 days postoperatively), minor complications due to hemorrhage (scored as Clavien–Dindo ≤ 2; i.e., extra TXA administration, hematemesis/melena, infected abdominal wall hematoma), length of hospital stay (LOS), general complications, side effects of TXA (VTE, hypotension, nausea and vomiting), and mortality within 3 months postoperative [24].
Statistical analysis
The estimated sample size was 2 × 50 = 100 patients. The analysis was based on an expected 50% decrease of the percentage of patients for whom peroperative placement of hemostatic clips was required (power = 80%, α = 5% two-sided) and an expected exclusion rate of 28%.
Statistical analyses were performed using IBM SPSS version 28 (IBM Corporation, Armonk, New York, USA). Outcomes were described as absolute number with percentage for categorical variables and as mean with standard deviation (SD) for parameters with normal distribution. For skewed data we used log transformation to create normally distributed data.
Differences in categorical data were tested using the Chi-squared test or Fisher’s exact test and differences in continuous data were tested using the independent sample t test or Mann–Whitney U test, as appropriate. In addition to the primary statistical tests, exploratory analyses, including Chi-squared test and linear or logistic regression analysis, were conducted to assess potential associations between variables of interest. Results were evaluated at a significance threshold of p < 0.05 (two-sided). Data were analyzed according to the as-treated principle.
Results
Between July 2, 2020, and August 23, 2021, 309 patients were assessed for eligibility. In total, 112 eligible patients were randomized to receive either TXA or placebo (Fig. 1). Eleven patients were excluded (five patients were deemed not fit for surgery by the anesthesiologist, two had peroperative iatrogenic arterial injury, two patients withdrew informed consent, and in two patients there was protocol violation). Between September 1, 2020 and October 12, 2021, 101 patients received the allocated treatment, 49 patients TXA and 52 patients placebo. All 101 patients completed 3-month follow-up. Baseline characteristics were comparable between both groups (Table 1).
Fig. 1
Flowchart. TXA tranexamic acid
Table 1
Baseline characteristics
TXA (n = 49)
Placebo (n = 52)
p-value
Age (years) (mean, SD)
36.0 (10.9)
36.8 (12.3)
p = 0.632a
Weight (kg) (mean, SD)
118.8 (19.8)
120.1 (24.4)
p = 0.671a
Body Mass Index (kg/m2) (mean, SD)
42.3 (5.4)
41.5 (5.3)
p = 0.444a
Female gender
38 (77.6%)
42 (80.8%)
p = 0.690b
Hypertension
8 (16.3%)
12 (23.1%)
p = 0.395b
Diabetes mellitus
2 (4.1%)
3 (5.8%)
p = 1.000c
Dyslipidemia
5 (10.2%)
5 (9.6%)
p = 1.000c
Obstructive sleep apnea
17 (34.7%)
18 (34.6)
p = 0.993b
Severe joint pain
8 (16.3%)
8 (15.4%)
p = 0.897b
Gastroesophageal reflux disease
4 (8.2%)
5 (9.6%)
p = 1.000c
Possible interacting medication (risk > 0.1%)
6 (12.2%)
4 (7.7%)
p = 0.518c
Heart rate (bpm) (mean, SD)
81.8 (10.3)
79.2 (12.4)
p = 0.245a
Systolic blood pressure (mmHg) (mean, SD)
129 (13.4)
132 (16.9)
p = 0.254a
Diastolic blood pressure (mmHg) (mean, SD)
75 (10.7)
74 (12.1)
p = 0.599a
Hemoglobin (mmol/L) (mean, SD)
8.8 (0.8)
8.7 (0.6)
p = 0.937a
Categorical data was answered with “yes”
TXA tranexamic acid, kg kilo gram, bpm beats per minute, SD standard deviation, mmHg millimeter of mercury, mmol/L millimoles per liter
aIndependent t test, bChi-squared test, cFisher exact test
×
Primary endpoint
During surgery, 34/49 (69%) patients in the TXA-group needed hemostatic clips for active bleeding at the staple line versus 43/52 (83%) patients in the placebo-group (Relative Risk (RR): 0.84 [95% CI 0.67 to 1.05], p = 0.161). There was no significant difference in the mean number of clips used between both groups (3.5 versus 4.2; between-group difference 0.18 [95% CI -0.18 to 0.70], p = 0.377) (Table 2). There was no difference in the utilization of hemostatic clip use among surgeons, this is described in greater detail in supplementary file 3.
Table 2
Peroperative outcomes
TXA (n = 49)
Placebo (n = 52)
Between-group difference (95% CI) or RR (95% CI)
p-value
Peroperative hemostatic clips used
34 (69.4%)
43 (82.7%)
RR: 0.84 (0.67 to 1.05)
p = 0.161b
Number of peroperative hemostatic clips used (mean, SD)
3.54 (2.7)
4.17 (2.4)
0.18 (− 0.18 to 0.70)
p = 0.377a
Fibrin sealant use peroperative
19 (38.8%)
23 (44.2%)
RR: 0.88 (0.55 to 1.40)
p = 0.687b
Staple device
Cartridge GOLD (3.0 mm)
Cartridge BLUE (2.4 mm)
Cartridge GREEN (3.4 mm)
49 (100%)
49 (100%)
4 (8.9%)
52 (100%)
52 (100%)
5 (9.6%)
p = 1.000c
Blood loss (milliliter) (mean, SD)
0
0
UTD
UTD
Length of surgery (minutes) (mean, SD)
34.1 (11.8)
34.8 (8.7)
0.71 (− 4.80 to 3.39)
p = 0.733a
Categorical data was answered with “yes”
TXA tranexamic acid, CI confidence interval, RR relative risk, SD standard deviation, UTD unable to determine, mm millimeter. aIndependent t test; bChi-squared test; cFisher exact test
*Indicates statistical significance (p < .05)
Secondary endpoints
Table 2 presents the peroperative outcomes. No differences were seen in the rate of fibrin sealant use (19 (38.8%) versus 23 (44.2%); RR: 0.88 [95% CI 0.55 to 1.40], p = 0.687) and blood loss (0 versus 0, UTD). Table 3 displays the postoperative outcomes. The TXA-group demonstrated a significantly smaller decrease in hemoglobin versus the placebo-group (0.55 mmol/L versus 0.80 mmol/L; between-group difference, 0.25 mmol/L [95% CI 0.05 to 0.44], p = 0.013). Results were comparable after correction for LOP in a sensitivity analysis. Patients who had postoperative vomiting (n = 14) or a major complication (n = 1) received > 500-cc NaCl after their postoperative hemoglobin levels had been determined. Change in heart rate was significantly lower in the TXA-group versus the placebo-group (− 4.6 bpm versus 2.5 bpm; between-group difference, 7.1 bpm [95% CI 1.53 to 12.69], p = 0.013), with comparable results after correction for pain and LOP in a sensitivity analysis. Seven (14.3%) patients in the TXA-group had extra postoperative hemoglobin monitoring versus seventeen (32.7%) in the placebo-group (RR: 0.44 [95% CI 0.20 to 0.96], p = 0.037). In the TXA-group, there were no postoperative hemorrhage (major complications) requiring intervention, compared with one patient in the placebo-group who underwent radiological drainage of an infected hematoma originating from a staple line bleeding. One (2.0%) patient had a minor complication in the TXA-group (≥ 1.5 points hemoglobin decrease) versus nine (17.3%) in the placebo-group (hematemesis n = 1, melena n = 1, infected abdominal wall hematoma n = 1, and TXA for ≥ 1.5 points hemoglobin decrease n = 7; (RR: 0.12 [95% CI 0.02 to 0.90], p = 0.016)). There was no statistically significant association between the number of hemostatic clips and the odds of postoperative hemorrhage-related complications (odds ratio: 1.03, [95% CI 0.55 to 1.17], p = 0.674). Results for minor complications were comparable after correction for LOP, surgeon, and color cartridge in a sensitivity analysis (see supplementary file 3). Figure 2 shows a significantly shorter stay in the TXA-group versus the placebo-group (mean hours; 30.8 versus 36.7, between-group difference 5.9 [95% CI -10.5 to − 1.3] p = 0.013). Four patients (8.2%) in the TXA-group were discharged ≥ 36 h after surgery (nausea n = 2, vomiting n = 1, and pain n = 1). In the placebo-group eleven patients (21.2%) were discharged ≥ 36 h after surgery (nausea n = 4, vomiting n = 2, pain n = 1, hemoglobin decrease n = 2, (irregular) tachycardia for which an electrocardiogram was necessary n = 1, and infected staple line hematoma n = 1). Peroperative: use of linear stapler cartridge and LOP and postoperative: pain, general complications, and side effects of TXA were not significantly different between both groups. No VTE and mortality were reported. Primary and secondary outcomes are presented in more detail in Tables 2 and 3.
Table 3
Postoperative outcomes
TXA (n = 49)
Placebo (n = 52)
Between-group difference (95% CI) or RR (95% CI)
p-value
Decrease in Hb level (mmol/L) (mean, SD)
− 0.55 (0.48)
− 0.80 (0.50)
0.25 (0.05 to 0.44)
p = 0.013a*
Increase in heart rate (bpm) (mean, SD)
− 4.6 (13.5)
2.5 (14.8)
7.11 (1.53 to 12.69)
p = 0.013a*
Pain (numeric rating scale) (mean, SD)
3.6 (1.9)
4.0 (1.7)
− 0.41 (− 1.11 to 0.30)
p = 0.256a
Intervention for hemorrhage
0 (0%)
1 (1.9%)
UTD
UTD
Patients with extra Hb monitoring
7 (14.3%)
17 (32.7%)
RR: 0.44 (0.20 to 0.96)
p = 0.037b*
Minor complications due to hemorrhage
1 (2.0%)
9 (17.3%)
RR: 0.12 (0.02 to 0.90)
p = 0.016c*
Hematemesis
0 (0%)
1 (1.9%)
UTD
UTD
Melena
0 (0%)
1 (1.9%)
UTD
UTD
TXA for decrease of > 1.5 Hb
1 (2.0%)
7 (13.5%)d
RR: 0.15 (0.02 to 1.19)
p = 0.060c
Infected abdominal wall hematoma
0 (0%)
1 (3.8%)
UTD
UTD
General complications
3 (6.1%)
10 (19.2%)
RR: 0.32 (0.09 to 1.09)
p = 0.073c
Length of stay (hours) (mean, SD)
30.8 (6.3)
34.7 (15.3)
− 5.9 (− 10.5 to − 1.3)
p = 0.013a*
Possible side effects TXA
VTE
0 (0%)
0 (0%)
UTD
UTD
Nausea
21 (42.9)
21 (40.4)
RR: 1.06 (0.67 to 1.69)
p = 0.842b
Vomiting
8 (16.3%)
6 (11.5%)
RR: 1.70 (0.60 to 4.84)
p = 0.381b
Systolic bp (mmHg) (mean, SD)
135.7(16.5)
138.8 (17.7)
− 3.09 (− 9.88 to 3.70)
p = 0.368a
Diastolic bp (mmHg) (mean, SD)
72.5 (9.4)
73.3 (10.5)
− 0.80 (− 4.74 to 3.14)
p = 0.687a
Mortality
0 (0%)
0 (0%)
UTD
UTD
Categorical data were answered with “yes”
TXA tranexamic acid, CI, confidence interval, RR relative risk, mmol/L millimoles per liter, SD standard deviation, bpm beats per minute, Hb hemoglobin, bp blood pressure, mmHg millimeter of mercury, VTE venous thrombotic events, UTD unable to determine
aIndependent t test; bChi-squared test; cFisher exact test. dOne patient is the patient with melena; this patient is counted once in the total number of complications
*Indicates statistical significance (p < .05)
Fig. 2
Bar chart of length of hospital stay between the TXA-group and placebo-group. All values are mean; whiskers show standard error of the mean. TXA tranexamic acid. *Indicates statistical significance (p < .05)
×
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Discussion
In the present study, TXA did not show a significant reduction in the use of hemostatic clips. However, peroperative administration of TXA in patients undergoing SG was associated with significant positive effects on clinical parameters, and minor complications correlated with hemorrhage and LOS, without increasing side effects, such as the risk of VTE.
To the best of our knowledge, this is the first randomized controlled trial investigating the effectiveness of peroperative administration of TXA in metabolic surgery. In other surgical fields, clinical trials have shown positive effects of TXA on all-cause mortality, reduction of blood loss, and a reduction risk of reoperations, without an increase of VTE [15, 25‐27]. The current incidence of VTE in patients undergoing metabolic surgery is relatively low, likely as a result of standard antithrombotic prophylaxis. Moreover, administration of TXA in metabolic and abdominal surgery does not seem to be associated with VTE [8, 25].
The available evidence of TXA in metabolic surgery comes from non-randomized and retrospective studies, showing less staple line bleedings in SG, low reoperation rates, and no increase in VTE [8, 18]. In the present study, hemostatic clips were used less frequently in patients receiving TXA. This difference was not statistically significant, whereas a non-randomized study in patients undergoing SG showed significantly less staple line bleeding points (19 versus 46, p < 0.05) requiring hemostatic stitches in patients receiving TXA versus patients without TXA [18]. The study might be underpowered to show a statistically significant difference in administration of TXA and the use of clips. Furthermore, no significant association was observed between the number of hemostatic clips used and postoperative complications. The literature lacks consensus in this regard, as some studies observed a reduction in postoperative bleeding after SLR, while others show no correlation and no cost-effective benefits [28‐31]. Another important factor is staple height. Theories differ, some suggest that a tighter staple line reduces bleeding risk, while others caution that excessive tightness may have a paradoxical effect, resulting in tissue crush which increases bleeding risk. This study found no significant difference in staple height between both groups. The influence of staple height should be further investigated.
Retrospective studies have shown a decrease in hemoglobin and an increase in heart rate as early signs of hemorrhage after metabolic surgery [32‐35]. In the present study, changes in both parameters were in favor of the TXA-group. A postoperative decrease in heart rate was seen in the TXA-group. One possible explanation is that patients who underwent successful surgery might experience less stress than preoperatively. Moreover, fewer minor complications due to hemorrhage occurred in the TXA-group. Although the differences in these prognostic factors did not translate into a significant reduction of hemorrhage and the difference in hemoglobin decrease was small, these findings might suggest a beneficial effect of TXA. However, further research is needed to gather more evidence and to evaluate the clinical relevance of this effect. In this study, patients who required more than 500 cc NaCl received it the day following their initial administration, after hemoglobin monitoring. However, if excess NaCl is administered beyond the protocolized volume before monitoring, such as in cases of immediate post-surgical major hemorrhage, it should be considered a potential covariate in the analysis.
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As hypothesized, interventions for hemorrhage were rare, as the (limited) sample size was based on reduced use of clips for peroperative bleeding points. One radiological intervention was performed in the placebo-group, due to an infected hematoma originating from the staple line, compared to none in the TXA-group. This reported hemorrhage rates are in line with larger series (2–3%) [6, 7]. To establish a potential beneficial effect of TXA on hemorrhage requiring intervention, a large randomized controlled trial is needed. Such a trial preformed in hysterectomy patients showed a significantly reduced risk of reoperations in the TXA-group (2/165 (1.2%) versus 9/167 (5.4%), p = 0.034) [36].
TXA is an inexpensive drug and might be of economic value [18, 37]. Although a formal cost-effectiveness analysis has not been performed, LOS was significantly shorter in the TXA-group. This may not have impact on surgery with an overnight admission, but could be beneficial in day-care surgery, which is increasingly performed.
This study had several limitations, including the fact that it was conducted in a single institution. Nevertheless, the double-blinded randomized design, in which all operations were performed by expert bariatric surgeons, makes the results widely applicable. Secondly, the primary endpoint consisted of factors indirectly associated with hemorrhage. The definition of this endpoint was chosen in order to limit the sample size and minimize the number of patients exposed to potential risks, as this is the first randomized trial investigating TXA in metabolic surgery. Thirdly, the study might have been underpowered to show a reduction in use of clips. Based on the current results, a sample size of 316 would have been required to demonstrate a statistically significant reduction in hemostatic clip use between TXA and placebo (α = 5%, power = 80%, TXA = 30.6%, placebo = 17.3%). Fourthly, thrombosis prophylaxis was only administered postoperatively, as this is standard of care in the Netherlands [22]. However, the absence of preoperative thrombosis prophylaxis did not result in an increase in thrombotic events and is supported by existing data [10, 22]. Finally, surgeons’ emphasis on staple line control may have biased the primary endpoint, resulting in increased use of hemostatic clip. Although, the intra-operative hemostasis was protocolized and consistently implemented by each surgeon (see supplementary file 2 and 3). We have designed a new trial (registration number: R22.102, ClinicalTrials.gov NCT05464394) to further investigate the potential of TXA in reducing postoperative hemorrhage, with postoperative interventions as primary outcome. This trial has been approved by the Medical Research Ethics Committees on February 7th, 2023. Additionally, given the increased bleeding risk associated with anticoagulant use [7], a study to assess the efficacy and safety of TXA in patients on anticoagulants would be valuable provided that safety measures are in place.
Conclusion
This study could not demonstrate a statistically significant difference in use of hemostatic clips and in major complications after peroperative administration of TXA. However, TXA seems to have a positive effect on postoperative hemoglobin, heart rate, minor complications due to hemorrhage and LOS in patients undergoing SG, without increasing VTE rate, and other side effects. A limitation of this study is the primary endpoint, reduction in hemostatic clips. To investigate whether TXA can reduce postoperative hemorrhages, we are conducting a larger randomized controlled trial with postoperative interventions as primary outcome.
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Declarations
Disclosures
The authors JWH‘tHart, BJNoordman, JMAWijnand, LUBiter, SJCV, EB, MD, JH, and JAA declare that they have no conflict of interest or financial ties to disclose.
Ethical approval
All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards. The study protocol was approved by the IRB and Medical Research Ethics Committees United (MEC-U), Nieuwegein, on July 29, 2019, the Netherlands (Protocol number R19.041).
Informed consent
Informed consent was obtained from all individual participants included in the study.
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