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European Journal of Nuclear Medicine and Molecular Imaging

Erschienen in:

01.07.2012 | Original Article

PET/CT for staging and follow-up of pediatric nasopharyngeal carcinoma

verfasst von: Daniel K. L. Cheuk, Noah D. Sabin, Moinul Hossain, Amy Wozniak, Mihir Naik, Carlos Rodriguez-Galindo, Matthew J. Krasin, Barry L. Shulkin

Erschienen in: European Journal of Nuclear Medicine and Molecular Imaging | Ausgabe 7/2012

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Abstract

Purpose

While FDG PET/CT for the evaluation of nasopharyngeal carcinoma (NPC) in adult patients has documented advantages and disadvantages compared with conventional imaging, to our knowledge, no studies of FDG PET/CT for the evaluation of NPC in pediatric patients have been performed. In this investigation, we studied the utility of FDG PET/CT in children with NPC.

Methods

The study group comprised 18 children with biopsy-proven NPC who underwent FDG PET/CT and MRI (total 38 pairs of images). All baseline and follow-up FDG PET/CT and MRI studies were independently reviewed for restaging of disease.

Results

The concordance between FDG PET/CT and MRI in T, N, and overall staging was 29%, 64%, and 43%, respectively. Compared with MRI, FDG PET/CT yielded lower T and overall staging and showed less cervical and retropharyngeal lymphadenopathy. The concordance between follow-up FDG PET/CT and MRI was 79% overall and 100% 9 months after therapy. In patients who achieved complete remission, FDG PET/CT showed disease clearance 3–6 months earlier than MRI. There were no false-positive or false-negative FDG PET/CT scans during follow-up.

Conclusion

FDG PET/CT may underestimate tumor extent and regional lymphadenopathy compared with MRI at the time of diagnosis, but it helps to detect metastases and clarify ambiguous findings. FDG PET/CT is sensitive and specific for follow-up and enables earlier determination of disease remission. FDG PET/CT is a valuable imaging modality for the evaluation and monitoring of NPC in pediatric patients.

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Titel: PET/CT for staging and follow-up of pediatric nasopharyngeal carcinoma
verfasst von: Daniel K. L. Cheuk
Noah D. Sabin
Moinul Hossain
Amy Wozniak
Mihir Naik
Carlos Rodriguez-Galindo
Matthew J. Krasin
Barry L. Shulkin
Publikationsdatum: 01.07.2012
Verlag: Springer-Verlag
Erschienen in: European Journal of Nuclear Medicine and Molecular Imaging / Ausgabe 7/2012
Print ISSN: 1619-7070
Elektronische ISSN: 1619-7089
DOI: https://doi.org/10.1007/s00259-012-2091-2

Springer Medizin

Abstract

Purpose

Methods

Results

Conclusion

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