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Forensic Science, Medicine and Pathology

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01.03.2013 | Case Report

Pharmacokinetic simulation of fatal carbamazepine intoxication in 23-month old child following phenytoin discontinuation

verfasst von: Jineane V. Venci, Meghan M. Rowcliffe, Lance Wollenberg, Michelle M. Rainka, Fran M. Gengo

Erschienen in: Forensic Science, Medicine and Pathology | Ausgabe 1/2013

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Abstract

The antiepileptic, carbamazepine, is extensively metabolized via hepatic enzymes in the cytochrome P450 family and is therefore subject to a myriad of drug interactions. Concomitant administration with phenytoin enhances carbamazepine metabolism thus reducing serum concentrations and necessitating the use of a higher maintenance dose. Removal of phenytoin therapy in the absence of anticipatory dose adjustments and careful monitoring of serum concentrations may result in catastrophic outcomes. Reported herein are the events leading to the death of a 23-month old child who suffered a fatal carbamazepine overdose following withdrawal of phenytoin therapy.

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Titel: Pharmacokinetic simulation of fatal carbamazepine intoxication in 23-month old child following phenytoin discontinuation
verfasst von: Jineane V. Venci
Meghan M. Rowcliffe
Lance Wollenberg
Michelle M. Rainka
Fran M. Gengo
Publikationsdatum: 01.03.2013
Verlag: Springer US
Erschienen in: Forensic Science, Medicine and Pathology / Ausgabe 1/2013
Print ISSN: 1547-769X
Elektronische ISSN: 1556-2891
DOI: https://doi.org/10.1007/s12024-012-9373-7

Springer Medizin

Pharmacokinetic simulation of fatal carbamazepine intoxication in 23-month old child following phenytoin discontinuation

Abstract

Neu im Fachgebiet Pathologie

Molekularpathologische Untersuchungen im Wandel der Zeit

Vergleichende Pathologie in der onkologischen Forschung

Gastrointestinale Stromatumoren

Personalisierte Medizin in der Onkologie

Springer Medizin

Abstract

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