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Translational Stroke Research

Erschienen in:

29.11.2017 | Review

Photothrombotic Stroke as a Model of Ischemic Stroke

verfasst von: Anatoly B. Uzdensky

Erschienen in: Translational Stroke Research | Ausgabe 5/2018

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Abstract

The search of effective anti-stroke neuroprotectors requires various stroke models adequate for different aspects of the ischemic processes. The photothrombotic stroke model is particularly suitable for the study of cellular and molecular mechanisms underlying neurodegeneration, neuroprotection, and neuroregeneration. It is a model of occlusion of small cerebral vessels, which provides detailed study of molecular mechanisms of ischemic cell death and useful for search of potential anti-stroke agents. Its advantages include well-defined location and size of ischemic lesion that are determined by the aiming of the laser beam at the predetermined brain region; easy impact dosing by changing light intensity and duration; low invasiveness and minimal surgical intervention without craniotomy and mechanical manipulations with blood vessel, which carry the risk of brain trauma; low animal mortality and prolonged sensorimotor impairment that provide long-term study of stroke consequences including behavior impairment and recovery; independence on genetic variations of blood pressure and vascular architecture; and high reproducibility. This review describes the current application of the photothrombotic stroke model for the study of cellular and molecular mechanisms of stroke development and ischemic penumbra formation, as well as for the search of anti-stroke drugs.

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Titel: Photothrombotic Stroke as a Model of Ischemic Stroke
verfasst von: Anatoly B. Uzdensky
Publikationsdatum: 29.11.2017
Verlag: Springer US
Erschienen in: Translational Stroke Research / Ausgabe 5/2018
Print ISSN: 1868-4483
Elektronische ISSN: 1868-601X
DOI: https://doi.org/10.1007/s12975-017-0593-8

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Photothrombotic Stroke as a Model of Ischemic Stroke

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