Introduction
Methods
Study population
Data
Statistical analyses
Results
Baseline characteristics
All | Survivors | Non-survivors | p valuei | |
---|---|---|---|---|
N = 30,614 (%) | N = 28,912 (%) | N = 1702 (%) | ||
Gender, male | 22,608 (74) | 21,431 (74) | 1177 (69) | < 0.001 |
Age, years | 63 (IQR 12) | 63 (IQR 12) | 67 (IQR 9) | < 0.001 |
STEMIa | 12,995 (42) | 12,370 (43) | 625 (37) | < 0.001 |
PCIb | 24,416 (80) | 23,292 (81) | 1124 (66) | < 0.001 |
LVEFc | < 0.001 | |||
> 50% | 20,394 (67) | 19,529 (68) | 865 (51) | |
40–49% | 6176 (20) | 5784 (20) | 392 (23) | |
30–39% | 3192 (10) | 2875 (10) | 317 (19) | |
< 30% | 852 (3) | 724 (3) | 128 (8) | |
Body mass index (kg/m2) | 27 (IQR 5) | 27 (IQR 5) | 26 (IQR 6) | < 0.001 |
Physical activity leveld | < 0.001 | |||
Low | 6434 (21) | 5745 (20) | 689 (41) | |
Medium | 8815 (29) | 8433 (29) | 382 (22) | |
High | 15,365 (50) | 14,734 (52) | 631 (37) | |
Smoking status | < 0.001 | |||
Never-smokers | 9849 (32) | 9421 (33) | 428 (25) | |
Former smokerse | 17 183 (56) | 16,243 (56) | 940 (55) | |
Smokers | 3582 (12) | 3248 (11) | 334 (20) | |
HQoLf, EQ5D | 0.85 (IQR 0.27) | 0.85 (IQR 0.27) | 0.80 (IQR 0.34) | < 0.001 |
eGFRg <60 mL/min/1.73 m2 | 28,174 (92) | 26,865 (93) | 1309 (77) | < 0.001 |
Full pharmacological treatmenth | 21,300 (70) | 20 173 (70) | 1127 (66) | 0.002 |
Mortality
Variable | Incidence | Full-time analysis (N = 30 614) | 5-year mortality (N = 11,066) | ||||
---|---|---|---|---|---|---|---|
Unadjusted HR | Adjusted HRa | Adjusted HRb | Unadjusted HR | Adjusted HRa | Adjusted HRb | ||
Physical activity levelc | |||||||
Low | 28.37 | Referent | Referent | Referent | Referent | Referent | Referent |
Medium | 11.13 | 0.39 (0.35–0.45)* | 0.42 (0.37–0.47)* | 0.52 (0.46–0.60)* | 0.40 (0.34–0.49)* | 0.44 (0.36–0.53)* | 0.55 (0.46–0.67)* |
High | 10.20 | 0.36 (0.32–0.40)* | 0.37 (0.33–0.41)* | 0.50 (0.45–0.56)* | 0.34 (0.29–0.40)* | 0.35 (0.30–0.42)* | 0.50 (0.42–0.59)* |
Smoking status | |||||||
Smokers | 24.36 | Referent | Referent | Referent | Referent | Referent | Referent |
Former smokersd | 13.79 | 0.56 (0.49–0.63)* | 0.45 (0.40–0.51)* | 0.50 (0.44–0.57)* | 0.56 (0.46–0.67)* | 0.56 (0.47–0.67)* | 0.50 (0.42–0.61)* |
Never-smokers | 10.84 | 0.45 (0.39–0.52)*† | 0.32 (0.28–0.37)*† | 0.38 (0.33–0.44)*† | 0.44 (0.36–0.55)*† | 0.44 (0.36–0.55)*† | 0.37 (0.29–0.46)*† |
Readmission
1-year readmission CVD N = 22,049 | 1-year readmission non-CVD N = 22,049 | |||||
---|---|---|---|---|---|---|
Variable | Unadjusted OR | Adjusted ORa | Adjusted ORb | Unadjusted OR | Adjusted ORa | Adjusted ORb |
Physical activity levelc | ||||||
Low | 1.0 referent | 1.0 referent | 1.0 referent | 1.0 referent | 1.0 referent | 1.0 referent |
Medium | 0.65 (0.58–0.73)*** | 0.65 (0.58–0.76)*** | 0.74 (0.66–0.83)*** | 0.59 (0.50–0.69)*** | 0.59 (0.50–0.69)*** | 0.65 (0.55–0.76)*** |
High | 0.63 (0.57–0.70)*** | 0.64 (0.58–0.71)*** | 0.75 (0.68–0.84)*** | 0.55 (0.47–0.63)*** | 0.56 (0.48–0.64) *** | 0.63 (0.55–0.73)*** |
Smoking status | ||||||
Smokers | 1.0 referent | 1.0 referent | 1.0 referent | 1.0 referent | 1.0 referent | 1.0 referent |
Former smokersd | 1.07 (0.93–1.22) | 1.10 (0.96–1.26) | 1.15 (0.99–1.34) | 1.02 (0.84–1.24) | 1.08 (0.88–1.31) | 1.18 (0.97–1.44) |
Never-smokers | 0.98 (0.85–1.13) | 1.00 (0.87–1.16) | 1.20 (1.04–1.38) | 1.10 (0.89–1.35) | 1.16 (0.94–1.43) | 1.34 (1.09–1.66)** |