Background
Methods
Study sample
Quantitative caries phenotypes
Statistical model
Results annotation and comparison with Caucasian caries GWASs
Results
Race | African American | Caucasian | ||
---|---|---|---|---|
Cohort | Adults | Children | Adults | Children |
N | 109 | 96 | 918 | 983 |
Age; mean (range) | 29.15 (18–58) | 7.30 (3–11) | 33.96 (18–64) | 6.37 (3–11) |
Male (%) | 38 (34.9%) | 48 (50.0%) | 683 (32.8%) | 616 (50.7%) |
Female (%) | 71 (65.1%) | 48 (50.0%) | 910 (57.1%) | 599 (49.3%) |
DMFT/dft; mean (range) | 7.17 (0–28) | 2.21 (0–12) | 10.39 (0–28) | 1.96 (0–17) |
DMFS/dfs; mean (range) | 18.2 (0–106) | 4.90 (0–35) | 23.00 (0–122) | 3.85 (0–53) |
PCs | 2 | 2 | 2 | 2 |
Genotyped SNPs | 529,015 | 529,837 | 526,525 | 510,212 |
Imputed SNPs | 4,907,119 | 4,912,366 | 4,915,678 | 4,931,991 |
GWASs of caries in the permanent dentition in African Americans
Lead SNP | CHR | BP | African-American cohort | Caucasian cohort | Q Statistic P-value | Nearby Gene(s) and Corroborating Evidence | |||
---|---|---|---|---|---|---|---|---|---|
Effect Size | SE | GWAS P-value | Effect Size | SE | |||||
rs74086974 | 1 | 71,335,753 | 4.522 | 0.904 | 3.18E-06 | PTGER3 Candidate gene for role in outcome of periodontal therapy and preterm birth [38]. ZRANB2 Affects bone morphogenic signaling [39]. Protein product binds bacterial LPS and Gram-negative bacteria, and has antibacterial function [40]. MIR186 Expressed differentially in health gingiva versus periodontitis gingiva [41]. | |||
rs1003652 | 2 | 10,468,296 | −3.563 | 0.734 | 4.39E-06 | 0.09572 | 0.4685 | 2.66E-05 | TAF1B Associated with non-syndromic cleft lip with palate in Chinese [42]. GRHL1 Differentially expressed between gingiva and dental follicles [43]. Differentially regulated in primary pulp stem cells by enamel matrix derivative [44]. PDIA6 Differentially expressed in soft tissue and bone after tooth extraction [46]. |
rs340349 | 2 | 179,933,412 | 4.79 | 0.833 | 2.20E-07 | 1.069 | 0.544 | 0.000184 | |
rs6434873 | 2 | 197,504,826 | 3.955 | 0.818 | 4.19E-06 | −0.02973 | 0.3442 | 7.11E-06 | PGAP1 Mouse gene knockout results in severe facial abnormalities, including lack of mouth, tongue, and mandible [47]. |
rs12488352 | 3 | 14,725,668 | 3.736 | 0.764 | 3.20E-06 | −0.9612 | 0.526 | 4.07E-07 | |
rs6441084 | 3 | 156,310,776 | 4.57 | 0.904 | 3.26E-06 | ||||
chr3:194035416 | 3 | 194,035,416 | −5.782 | 0.891 | 1.60E-07 | HES1 Part of Notch signaling pathway involved in tooth development [48]. Promotes antimicrobial response in epithelial cells [49]. Regulates taste cell differentiation, specifically of the sweet-, bitter-, and umami-sensing cells [50]. LSG1 Differentially expressed between the sexes in minor salivary glands [51]. | |||
rs62295581 | 4 | 11,844,859 | 6.403 | 1.173 | 2.05E-06 | −0.6366 | 0.5008 |
3.40E-08
| |
chr4:158617368 | 4 | 158,617,368 | 7.46 | 1.375 | 2.76E-06 | ||||
rs28503910 | 4 | 182,680,709 | 4.983 | 0.973 | 4.84E-06 | 0.1327 | 0.4536 | 6.27E-06 | MIR1305 Upregulated in smoker periodontal ligament-derived stem cells, and may impair the regenerative potential of this tissue [52]. |
rs12171500 | 5 | 76,460,134 | 15.92 | 2.507 | 1.37E-06 | 0.1616 | 0.4686 |
6.46E-10
| IQGAP2 Involved in tooth development; upregulated in ameloblastoma [53]. S100Z Upregulated as part of ameloblastoma signature [54]. CRHBP One of most up-regulated genes in deciduous tooth pulp, as compared to that of permanent teeth [55]. F2R Encodes a transcription factor (PAR1) important for enamel formation [56]. |
rs12154393 | 7 | 11,210,931 | 3.828 | 0.762 | 3.06E-06 | 0.1274 | 0.3092 | 6.86E-06 | NDUFA4 Candidate gene for role in cellular aging in dental follicle stem cells [57]. THSD7A Obesity candidate gene [58]. |
rs6947348 | 7 | 26,383,748 | 4.615 | 0.799 | 1.70E-07 | 0.3809 | 0.437 | 3.35E-06 | MIR148 Involved in dental stem cells [59]. |
rs10224789 | 7 | 111,953,442 | 5.797 | 1.041 | 8.19E-07 | IFRD1 Nociceptive pathway gene and risk factor for temporomandibular disorders [62]. | |||
rs817156 | 9 | 98,469,359 | 4.865 | 0.982 | 3.99E-06 | −0.2586 | 0.3784 | 1.13E-06 | PTCH1 Encodes the main receptor for the Hedgehog signaling pathway; mutations can cause odontogenic keratocysts, orofacial clefting, and hypodontia [63]. |
rs112246048 | 10 | 7,562,045 | 4.998 | 0.948 | 3.89E-06 | −0.7608 | 0.6298 | 4.20E-07 | |
rs7107282 | 11 | 26,965,751 | 3.959 | 0.805 | 3.21E-06 | SLC5A12 Lactate transporter in T-cells which enables T-cells to sense inflammatory environments [64]. CCDC34 Bone mineral density-related candidate gene [65]. LGR4 Required for sequential development of molars [66]. | |||
rs483743 | 13 | 113,786,947 | 3.82 | 0.743 | 1.39E-06 | −0.08544 | 0.4209 | 4.82E-06 | |
rs4331298 | 15 | 71,918,351 | 4.054 | 0.818 | 3.01E-06 | −0.6631 | 0.3067 |
6.75E-08
| |
rs72787939 | 16 | 26,556,887 | 4.617 | 0.819 | 6.34E-07 | −1.076 | 0.4973 |
2.81E-09
| |
chr16:28719857 | 16 | 28,719,857 | 5.25 | 0.962 | 4.36E-06 | APOBR Associated with body fat percentage [67] (Lu et al., 2016). SH2B1 Associated with BMI, and is implicated in leptin signaling [68]. | |||
rs2317828 | 16 | 82,266,591 | 3.72 | 0.727 | 1.55E-06 | PLCG2 May play crucial role in odontogenesis [69]. CDH13 Gene product may regulate the morphogenesis and rearrangement of secretory ameloblast cells [70]. | |||
rs321946 | 19 | 52,859,828 | −3.552 | 0.716 | 2.54E-06 | 0.5165 | 0.4073 | 7.83E-07 | |
rs62225548 | 21 | 41,902,731 | −3.693 | 0.700 | 6.41E-07 | −0.2548 | 0.3871 | 1.71E-05 | |
rs2838538 | 21 | 45,687,271 | 4.606 | 0.914 | 4.34E-06 | −0.1598 | 0.3027 | 7.48E-07 | CTSB Salivary levels of encoded protein are reduced in chronic graft-versus-host disease, which affects the saliva in the majority of patients [71]. AIRE Mutations cause autoimmune polyendocrinopathy candidiasis-ectodermal dystrophy, a feature of which can be dental abnormalities [72]. TRPM2 Encodes an ion channel whose expression is increased in dental pulpitis. TRPM2 is activated in cancer radiation treatments to suppress Ca2+ signaling required for saliva production [73]. TSPEAR Mutations affect Notch signaling and cause an ectodermal dysplasia causing features including hypodontia [74]. |
Lead SNP | CHR | BP | African-American cohort | Caucasian cohort | Q Statistic P-value | Nearby Gene(s) and Corroborating Evidence | |||
---|---|---|---|---|---|---|---|---|---|
Effect Size | SE | P-value | Effect Size | SE | |||||
rs1122613 | 1 | 3,768,565 | −12.54 | 2.525 | 2.72E-06 | 1.395 | 1.121 | 4.56E-07 | ARHGEF16 Candidate biomarker for diagnosis of oral squamous cell carcinoma [75]. |
rs1003652 | 2 | 10,468,296 | −11.67 | 2.47 | 4.54E-06 | 1.04 | 1.497 | 9.86E-06 | TAF1B Candidate gene for susceptibility to non-syndromic cleft lip with palate [42]. GRHL1 Differentially expressed between gingiva and dental follicles [43], differentially regulated in primary pulp stem cells by enamel matrix derivative [44]. KLF11 Involved in tooth development, specifically odontoblast differentiation [45]. PDIA6 Differentially expressed in soft tissue and bone after tooth extraction [46]. |
rs12488352 | 3 | 14,725,668 | 12.68 | 2.576 | 2.97E-06 | − 3.552 | 1.679 | 1.30E-07 | |
chr3:194035416 | 3 | 194,035,416 | −18.1 | 3.34 | 2.48E-06 | HES1 Part of Notch signaling pathway involved in tooth development [48]. Promotes antimicrobial response in epithelial cells [49]. Regulates taste cell differentiation, specifically of the sweet-, bitter-, and umami-sensing cells [50]. LSG1 Differentially expressed between the sexes in minor salivary glands [51]. | |||
rs28503910 | 4 | 182,680,709 | 17.13 | 3.055 | 1.99E-06 | −0.9102 | 1.454 | 9.71E-08 | |
rs12171500 | 5 | 76,460,134 | 57.37 | 7.984 | 1.96E-06 | 0.8305 | 1.491 |
3.37E-12
| IQGAP2 Involved in tooth development; upregulated in ameloblastoma [53]. S100Z Upregulated as part of ameloblastoma signature [54]. SNORA47 Upregulated as part of ameloblastoma signature [54]. CRHBP One of most up-regulated genes in deciduous tooth pulp, as compared to that of permanent teeth [55]. F2R Encodes a transcription factor (PAR1) important for enamel formation [56]. |
rs6947348 | 7 | 26,383,748 | 14.59 | 2.698 | 1.38E-06 | 1.265 | 1.402 | 1.17E-05 | MIR148 Involved in dental stem cells [59]. |
rs66691214 | 7 | 30,188,804 | 13.79 | 2.459 | 7.24E-07 | 0.9477 | 0.9689 | 1.18E-06 | NOD1 Innate immunity gene expressed by dental pulp fibroblasts in the recognition of invaded caries-related bacteria and the subsequent innate immune responses [78]; gene product mediates sensing of periodontal pathogens [79], including P. gingivalis [80]. Required for the bone resorption consequences of immune activation by commensal bacteria in a model of periodontitis [81]. |
rs7011390 | 8 | 66,304,329 | 12.96 | 2.634 | 3.48E-06 | 0.7342 | 1.329 | 3.41E-05 | |
rs72787939 | 16 | 26,556,887 | 15.85 | 2.63 | 2.20E-07 | −4.171 | 1.594 |
7.51E-11
| HS3ST4 Heparan sulfate proteoglycans are coreceptors for FGFR22b, whose signaling is essential for progenitor survival and proliferation in several organs, including the submandibular gland and the tooth [82] |
rs4801855 | 19 | 51,348,572 | − 17.33 | 3.459 | 3.24E-06 | − 0.4175 | 1.005 | 2.66E-06 | POLD1 Mutations cause Mandibular Hypoplasia, Deafness and Progeroid features (MDP) syndrome, a premature aging syndrome which results in severe dental crowding and irregular teeth [83]. ACPT Recessive mutations in ACPT cause hypoplastic amelogenesis imperfecta; ACPT supplies phosphate during dentine formation [84]. KLK1 Protein product is abundant in salivary proteome [85], and is involved in cellular inflammatory processes [86]. KLK4 Homozygous mutations cause hypomaturation amelogenesis imperfecta [87]. SIGLEC9 Modulates innate immunity [88]. CD33 Encodes immunomodulatory receptor [89]. |
GWASs of caries in the primary dentition in African Americans
Lead SNP | CHR | BP | African-American cohort | Caucasian cohort | Q Statistic P-value | Nearby Gene(s) and Corroborating Evidence | |||
---|---|---|---|---|---|---|---|---|---|
Effect Size | SE | P-value | Effect Size | ||||||
12,125,935 | 1 | 158,438,592 | 2.263 | 0.428 | 2.78E-06 | CD1D Gene product mediates mucosal immunity [90]. CD1A Encodes antigen-presenting protein expressed in oral epithelial cells [91]. CD1C Expressed in gingival environment on dendritic cells [92]. | |||
rs11718323 | 3 | 20,915,514 | 9.527 | 1.462 | 2.37E-06 | 0.44 | 0.285 |
1.06E-09
| |
rs78777602 | 3 | 24,821,055 | 9.482 | 1.438 | 1.29E-06 | −0.1403 | 0.2646 |
4.67E-11
| RARB Likely targeted by miRNAs involved in tooth morphogenesis and differentiation of dental cells [96]. Upregulated in ameloblastoma [53]. Has increased methylation in context of/is associated with head and neck squamous cell carcinoma, which is associated with dental hygiene and inflammation due to microbial factors [97]. |
rs1568206 | 3 | 106,639,719 | 3.087 | 0.505 | 9.33E-07 | 0.04032 | 0.2202 |
3.25E-08
| |
rs1505809 | 3 | 131,901,392 | 1.867 | 0.588 | 4.99E-06 | ||||
rs11932181 | 4 | 17,279,517 | −2.104 | 0.410 | 2.18E-06 | ||||
rs1352733 | 4 | 112,280,742 | 2.372 | 0.443 | 3.47E-06 | −0.1662 | 0.149 | 5.51E-08 | |
rs62316615 | 4 | 113,527,072 | 8.023 | 1.264 | 2.68E-06 | −0.1937 | 0.2483 |
1.79E-10
| GWAS signal is near gene desert that contains several enhancer elements that influence PITX2 expression involved in Axenfeld-Rieger syndrome, which presents with dental anomalies (hypodontia, delayed primary tooth eruption, retrognathia of maxilla and mandible) [98]. LARP7 Homozygous mutations cause Alazami syndrome, a feature of which is craniofacial dysmorphism [99]. MIR302A Promotes osteoblast differentiation [100]. |
rs57805404 | 4 | 190,403,652 | 3.667 | 0.608 | 1.54E-06 | ||||
rs11741099 | 5 | 178,664,463 | 1.96 | 0.400 | 2.93E-06 | 0.01215 | 0.1403 | 4.22E-06 | RUFY1 Encodes protein that is part of the machinery that addresses periodontal pathogen intrusions in oral epithelial barriers [101]. MAML1 Part of Notch signaling pathway, plays role in bone development [102]. GRM6 Transcribed in a healthy gingival state [103]. |
rs61497549 | 7 | 5,842,842 | 2.343 | 0.448 | 2.78E-06 | ||||
rs1235058 | 7 | 54,614,145 | 2.256 | 0.425 | 3.14E-06 | 0.2763 | 0.1708 | 1.53E-05 | HPVC1 Candidate gene for a complex chronic periodontitis trait involving a mixed infection bacterial community [107]. VSTM2A Exhibits high expression in mandibular molars relative to incisors [108]. |
rs2515501 | 8 | 6,412,625 | 6.477 | 0.722 | 4.54E-06 | −0.1906 | 0.1931 |
4.39E-10
| ANGPT2 Upregulated in response to P. gingivalis; elevated levels are associated with oral squamous cell carcinoma [113]). |
rs10504504 | 8 | 72,185,924 | 4.625 | 0.771 | 3.23E-06 | −0.06708 | 0.2221 |
4.98E-09
| |
rs74949229 | 10 | 9,526,946 | 7.142 | 0.455 | 4.38E-06 | 0.2898 | 0.2229 |
2.53E-09
| |
rs6585998 | 10 | 87,943,609 | − 2.107 | 0.428 | 2.78E-06 | −0.18 | 0.1382 | 1.79E-05 | MIR346 Involved in osteogenic differentiation of human bone marrow mesenchymal stem cells [118]. |
rs11020123 | 11 | 92,689,278 | −2.269 | 0.991 | 4.10E-06 | 0.13 | 0.1328 | 4.16E-07 | FAT3 One of genes enriched in the GO category “calcium ion binding” that are differentially expressed throughout different stages of tooth development [119]. MTNR1B Locus associated with type II diabetes [120]. |
rs79812076 | 12 | 102,989,156 | 6.012 | 0.967 | 2.17E-06 | 0.5207 | 0.2254 |
3.16E-08
| IGF1 Encodes metabolism regulator of hard dental tissue through action on IGF1-receptor; is involved in later stages of tooth development and pulpal differentiation [121]. |
rs9630337 | 13 | 68,582,970 | 6.97 | 1.128 | 4.47E-06 | −0.5214 | 0.2149 |
3.07E-11
| |
chr13:96271864 | 13 | 96,271,864 | 8.184 | 1.308 | 3.62E-06 | CLDN10 Expressed in preodontoblasts, and restricted to the lingual basal epithelium of the tooth bud [122]. HS6ST3 Associated with obesity (BMI ≥ 35 kg/m2) [123]. | |||
rs422342 | 15 | 67,347,686 | 2.865 | 0.543 | 2.39E-06 | 0.31 | 0.2138 | 1.20E-05 | SMAD6 Highly expressed in bone, including mandible and palatal bone [124]. SMAD3 Expressed in intramembranous bones and submandibular salivary gland [124]. MAP 2 K5 Associated with BMI [125]. |
rs7174369 | 15 | 99,830,322 | 2.586 | 0.482 | 1.72E-06 | 0.1903 | 0.1358 | 1.68E-06 | MEF2A Regulates osteogenic differentiation of dental pulp stem cells [126]. IGF1R IGF-receptor; involved in signaling in dental fibroblast apoptosis [127]. |
rs9915753 | 17 | 73,011,448 | 3.814 | 1.107 | 4.50E-06 | −0.02813 | 0.143 | 1.81E-07 | SLC9A3R1 Mutations cause hypophosphatemic nephrolithiasis/osteoporosis 2, features of which can include skeletal defects, fractures, and osteoporosis/osteopenia [128]. |
rs2012033 | 19 | 34,163,298 | 2.248 | 0.424 | 8.21E-07 | 0.1823 | 0.1637 | 5.37E-06 | CHST8 Candidate gene for hypodontia [129]. KCTD15 Associated with obesity and preference for carbohydrates [130]. |
rs55928325 | 19 | 56,507,948 | 3.22 | 1.051 | 4.70E-06 | 0.06884 | 0.2314 | 6.11E-07 | NLRP5 Increased expression in mucosa in state of periodontitis [131], and part of gene expression network preferentially expressed in lower incisors [108]. ZNF582 Hypermethylation is associated with oral dysplasia and cancer [132]. |
Lead SNP | CHR | BP | African-American cohort | Caucasian cohort | Q Statistic P-value | Nearby Gene(s) and Corroborating Evidence | |||
---|---|---|---|---|---|---|---|---|---|
Effect Size | SE | P-value | Effect Size | ||||||
rs11240576 | 1 | 205,816,923 | 6.548 | 1.338 | 4.36E-06 | ||||
rs74574927 | 3 | 24,768,865 | 16.13 | 2.251 | 2.44E-06 | −0.6646 | 0.6546 |
7.83E-13
| RARB Likely targeted by miRNAs involved in tooth morphogenesis and differentiation of dental cells [96]. Upregulated in ameloblastoma [53]. Has increased methylation in context of/is associated with head and neck squamous cell carcinoma, which, in turn, is associated with dental hygiene and inflammation due to microbial factors [97]. |
rs7630386 | 3 | 29,024,237 | 22.38 | 2.805 | 9.51E-07 | RBMS3 Candidate gene for a complex chronic periodontitis trait involving a periodontal pathogen load [107]. | |||
rs1505809 | 3 | 131,901,392 | 5.215 | 1.089 | 9,301,573 | ||||
rs552922 | 3 | 150,281,061 | 6.1 | 1.074 | 4.19E-06 | 0.08645 | 0.2895 | 6.44E-08 | |
rs11932181 | 4 | 17,279,517 | −5.766 | 1.66 | 4.94E-06 | ||||
rs1602815 | 4 | 131,105,072 | 7.756 | 1.35 | 2.47E-06 | 0.1524 | 0.3582 | 5.21E-08 | |
rs36162355 | 5 | 2,246,469 | 11.62 | 1.926 | 4.38E-06 | IRX4 Differentially expressed in incisors versus molars [108]. IRX2 Localizes to cervical loop during replacement tooth morphogenesis in fish model [133]. | |||
rs17606253 | 6 | 111,526,445 | 12.19 | 1.928 | 1.85E-06 | 0.2342 | 0.4277 |
1.41E-09
| TRAF3IP2 Involved in mucosal immunity and IL-17 signaling, and associated with a complex chronic periodontitis trait involving high levels of A. actinomycetemcomitans and a profile of aggressive periodontal disease [107]. |
rs10815750 | 9 | 8,087,319 | 5.522 | 1.05 | 1.55E-06 | 0.1317 | 0.3258 | 9.44E-07 | |
rs1434274 | 9 | 8,817,244 | 6.899 | 1.306 | 4.53E-06 | −0.08817 | 0.3447 | 2.30E-07 | |
rs11008779 | 10 | 32,413,987 | 9.853 | 1.725 | 3.22E-06 | −0.4776 | 0.3681 |
4.72E-09
| |
rs6585998 | 10 | 87,943,609 | −5.642 | 1.184 | 4.45E-06 | −0.5171 | 0.3351 | 3.12E-05 | MIR346 Predicted to regulate a gene related to calcium binding during amelogenesis [119]. |
rs6483205 | 11 | 92,669,908 | −7.844 | 1.396 | 1.24E-06 | 0.4095 | 0.3187 |
8.22E-09
| FAT3 Gene enriched in the GO category “calcium ion binding” and are differentially expressed throughout different stages of tooth development [119]. |
rs61950818 | 13 | 63,216,679 | 15.35 | 2.346 | 2.70E-06 | − 0.01181 | 0.4964 |
1.49E-10
| |
rs9915753 | 17 | 73,011,448 | 12.24 | 1.905 | 3.60E-07 | −0.1695 | 0.348 |
1.47E-10
| CD300E Significantly upregulated in healing gingiva [136]. SLC9A3R1 Heterozygous mutations cause hypophosphatemic nephrolithiasis/osteoporosis which causes decreased bone mineral density [128]. |
rs2012033 | 19 | 34,163,298 | 5.763 | 1.136 | 1.40E-06 | 0.6308 | 0.3967 | 2.00E-05 | CHST8 Candidate gene for hypodontia [129]. KCTD15 Associated with obesity and preference for carbohydrates [130]. |
Comparison with Caucasian caries GWAS
Phenotype | SNP | CHR | BP | P-value (AA) | Effect Size (AA) | SE (AA) | Effect Size (C) | SE (C) | Q Statistic P-value |
---|---|---|---|---|---|---|---|---|---|
DMFT | rs62295581 | 4 | 11,844,859 | 2.05E-06 | 6.403 | 1.173 | − 0.6366 | 0.5008 | 3.40E-08 |
rs12171500 | 5 | 76,460,134 | 1.37E-06 | 15.92 | 2.507 | 0.1616 | 0.4686 | 6.46E-10 | |
rs4331298 | 15 | 71,918,351 | 3.01E-06 | 4.054 | 0.818 | −0.6631 | 0.3067 | 6.75E-08 | |
rs72787939 | 16 | 26,556,887 | 6.34E-07 | 4.617 | 0.8189 | −1.076 | 0.4973 | 2.81E-09 | |
DMFS | rs12171500 | 5 | 76,460,134 | 1.96E-06 | 57.37 | 7.984 | 0.8305 | 1.491 | 3.37E-12 |
rs72787939 | 16 | 26,556,887 | 2.20E-07 | 15.85 | 2.63 | −4.171 | 1.594 | 7.51E-11 | |
dft | rs11718323 | 3 | 20,915,514 | 2.37E-06 | 9.527 | 1.462 | 0.44 | 0.285 | 1.06E-09 |
rs78777602 | 3 | 24,821,055 | 1.29E-06 | 9.482 | 1.438 | −0.1403 | 0.2646 | 4.67E-11 | |
rs1568206 | 3 | 1.07E+ 08 | 9.33E-07 | 3.087 | 0.5053 | 0.04032 | 0.2202 | 3.25E-08 | |
rs1112769 | 3 | 1.88E+ 08 | 3.65E-06 | 5.947 | 0.9909 | −0.3341 | 0.2187 | 6.02E-10 | |
rs62316615 | 4 | 1.14E+ 08 | 2.68E-06 | 8.023 | 1.264 | −0.1937 | 0.2483 | 1.79E-10 | |
rs2515501 | 8 | 6,412,625 | 4.54E-06 | 6.477 | 1.051 | −0.1906 | 0.1931 | 4.39E-10 | |
rs10504504 | 8 | 72,185,924 | 3.23E-06 | 4.625 | 0.771 | −0.06708 | 0.2221 | 4.98E-09 | |
rs74949229 | 10 | 9,526,946 | 4.38E-06 | 7.142 | 1.128 | 0.2898 | 0.2229 | 2.53E-09 | |
rs79812076 | 12 | 1.03E+ 08 | 2.17E-06 | 6.012 | 0.9667 | 0.5207 | 0.2254 | 3.16E-08 | |
rs9630337 | 13 | 68,582,970 | 4.47E-06 | 6.97 | 1.107 | −0.5214 | 0.2149 | 3.07E-11 | |
dfs | rs74574927 | 3 | 24,768,865 | 2.44E-06 | 16.13 | 2.251 | −0.6646 | 0.6546 | 7.83E-13 |
rs17606253 | 6 | 1.12E+ 08 | 1.85E-06 | 12.19 | 1.928 | 0.2342 | 0.4277 | 1.41E-09 | |
rs11008779 | 10 | 32,413,987 | 3.22E-06 | 9.853 | 1.725 | −0.4776 | 0.3681 | 4.72E-09 | |
rs61950818 | 13 | 63,216,679 | 2.70E-06 | 15.35 | 2.346 | −0.01181 | 0.4964 | 1.49E-10 | |
rs9915753 | 17 | 73,011,448 | 3.60E-07 | 12.24 | 1.905 | −0.1695 | 0.348 | 1.47E-10 | |
rs74574927 | 3 | 24,768,865 | 2.44E-06 | 16.13 | 2.251 | −0.6646 | 0.6546 | 7.83E-13 |