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Erschienen in: Acta Neurochirurgica 12/2011

01.12.2011 | Review Article

Pituitary surgery: legacies from the past

verfasst von: Julie Dubourg, Emmanuel Jouanneau, Mahmoud Messerer

Erschienen in: Acta Neurochirurgica | Ausgabe 12/2011

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Abstract

Pituitary surgery is a recent development in neurosurgery and most of the surgical techniques concerned have been described within the last century. We provide a historical perspective by reviewing the major steps in the development of this neurosurgical subspecialty through the ages. We concentrate on the most important figures whose advances in the study of the physiology and anatomy of the pituitary are most significant. This journey into the past will demonstrate that our current knowledge is the summation of a long road of investigation.
Literatur
1.
Zurück zum Zitat Apuzzo ML, Heifetz MD, Weiss MH, Kurze T (1977) Neurosurgical endoscopy using the side-viewing telescope. J Neurosurg 46:398–400PubMedCrossRef Apuzzo ML, Heifetz MD, Weiss MH, Kurze T (1977) Neurosurgical endoscopy using the side-viewing telescope. J Neurosurg 46:398–400PubMedCrossRef
2.
Zurück zum Zitat Artico M, Pastore FS, Fraioli B, Giuffre R (1998) The contribution of Davide Giordano (1864–1954) to pituitary surgery: the transglabellar-nasal approach. Neurosurgery 42:909–911, discussion 911–902PubMedCrossRef Artico M, Pastore FS, Fraioli B, Giuffre R (1998) The contribution of Davide Giordano (1864–1954) to pituitary surgery: the transglabellar-nasal approach. Neurosurgery 42:909–911, discussion 911–902PubMedCrossRef
3.
4.
Zurück zum Zitat Bushe KA, Halves E (1978) Modified technique in transsphenoidal operations of pituitary adenomas. Technical note (author’s transl). Acta Neurochir (Wien) 41:163–175CrossRef Bushe KA, Halves E (1978) Modified technique in transsphenoidal operations of pituitary adenomas. Technical note (author’s transl). Acta Neurochir (Wien) 41:163–175CrossRef
5.
Zurück zum Zitat Cappabianca P, Alfieri A, Colao A, Ferone D, Lombardi G, de Divitiis E (1999) Endoscopic endonasal transsphenoidal approach: an additional reason in support of surgery in the management of pituitary lesions. Skull Base Surg 9:109–117PubMedCrossRef Cappabianca P, Alfieri A, Colao A, Ferone D, Lombardi G, de Divitiis E (1999) Endoscopic endonasal transsphenoidal approach: an additional reason in support of surgery in the management of pituitary lesions. Skull Base Surg 9:109–117PubMedCrossRef
6.
Zurück zum Zitat Cappabianca P, Cavallo LM, Esposito F, de Divitiis E (2004) Endoscopic endonasal transsphenoidal surgery: procedure, endoscopic equipment and instrumentation. Childs Nerv Syst 20:796–801PubMedCrossRef Cappabianca P, Cavallo LM, Esposito F, de Divitiis E (2004) Endoscopic endonasal transsphenoidal surgery: procedure, endoscopic equipment and instrumentation. Childs Nerv Syst 20:796–801PubMedCrossRef
7.
Zurück zum Zitat Cappabianca P, de Divitiis E (2004) Endoscopy and transsphenoidal surgery. Neurosurgery 54:1043–1048, discussions 1048–1050PubMedCrossRef Cappabianca P, de Divitiis E (2004) Endoscopy and transsphenoidal surgery. Neurosurgery 54:1043–1048, discussions 1048–1050PubMedCrossRef
8.
Zurück zum Zitat Cappabianca P, de Divitiis E (2007) Back to the Egyptians: neurosurgery via the nose. A five-thousand-year history and the recent contribution of the endoscope. Neurosurg Rev 30:1–7, discussion 7PubMedCrossRef Cappabianca P, de Divitiis E (2007) Back to the Egyptians: neurosurgery via the nose. A five-thousand-year history and the recent contribution of the endoscope. Neurosurg Rev 30:1–7, discussion 7PubMedCrossRef
9.
Zurück zum Zitat Cho DY, Liau WR (2002) Comparison of endonasal endoscopic surgery and sublabial microsurgery for prolactinomas. Surg Neurol 58:371–375, discussion 375–376PubMedCrossRef Cho DY, Liau WR (2002) Comparison of endonasal endoscopic surgery and sublabial microsurgery for prolactinomas. Surg Neurol 58:371–375, discussion 375–376PubMedCrossRef
10.
Zurück zum Zitat Cockett WS, Cockett AT (1998) The Hopkins rod-lens system and the Storz cold light illumination system. Urology 51:1–2PubMedCrossRef Cockett WS, Cockett AT (1998) The Hopkins rod-lens system and the Storz cold light illumination system. Urology 51:1–2PubMedCrossRef
11.
Zurück zum Zitat Couldwell WT (2004) Transsphenoidal and transcranial surgery for pituitary adenomas. J Neurooncol 69:237–256PubMedCrossRef Couldwell WT (2004) Transsphenoidal and transcranial surgery for pituitary adenomas. J Neurooncol 69:237–256PubMedCrossRef
12.
Zurück zum Zitat Cushing H (1979) The pituitary body and its disorders. Classics of Medicine, Birmingham Cushing H (1979) The pituitary body and its disorders. Classics of Medicine, Birmingham
13.
Zurück zum Zitat Cushing H (1981) Medical Classic. The functions of the pituitary body: Harvey Cushing. Am J Med Sci 281:70–78PubMedCrossRef Cushing H (1981) Medical Classic. The functions of the pituitary body: Harvey Cushing. Am J Med Sci 281:70–78PubMedCrossRef
14.
Zurück zum Zitat D’Haens J, Van Rompaey K, Stadnik T, Haentjens P, Poppe K, Velkeniers B (2009) Fully endoscopic transsphenoidal surgery for functioning pituitary adenomas: a retrospective comparison with traditional transsphenoidal microsurgery in the same institution. Surg Neurol 72:336–340PubMedCrossRef D’Haens J, Van Rompaey K, Stadnik T, Haentjens P, Poppe K, Velkeniers B (2009) Fully endoscopic transsphenoidal surgery for functioning pituitary adenomas: a retrospective comparison with traditional transsphenoidal microsurgery in the same institution. Surg Neurol 72:336–340PubMedCrossRef
15.
Zurück zum Zitat de Divitiis E (2006) Endoscopic transsphenoidal surgery: stone-in-the-pond effect. Neurosurgery 59:512–520, discussion 512–520PubMedCrossRef de Divitiis E (2006) Endoscopic transsphenoidal surgery: stone-in-the-pond effect. Neurosurgery 59:512–520, discussion 512–520PubMedCrossRef
16.
17.
Zurück zum Zitat Elias WJ, Chadduck JB, Alden TD, Laws ER Jr (1999) Frameless stereotaxy for transsphenoidal surgery. Neurosurgery 45:271–275, discussion 275–277PubMedCrossRef Elias WJ, Chadduck JB, Alden TD, Laws ER Jr (1999) Frameless stereotaxy for transsphenoidal surgery. Neurosurgery 45:271–275, discussion 275–277PubMedCrossRef
18.
Zurück zum Zitat Fahlbusch R, Ganslandt O, Buchfelder M, Schott W, Nimsky C (2001) Intraoperative magnetic resonance imaging during transsphenoidal surgery. J Neurosurg 95:381–390PubMedCrossRef Fahlbusch R, Ganslandt O, Buchfelder M, Schott W, Nimsky C (2001) Intraoperative magnetic resonance imaging during transsphenoidal surgery. J Neurosurg 95:381–390PubMedCrossRef
19.
Zurück zum Zitat Fatemi N, Dusick JR, de Paiva Neto MA, Kelly DF (2008) The endonasal microscopic approach for pituitary adenomas and other parasellar tumors: a 10-year experience. Neurosurgery 63:244–256, discussion 256PubMedCrossRef Fatemi N, Dusick JR, de Paiva Neto MA, Kelly DF (2008) The endonasal microscopic approach for pituitary adenomas and other parasellar tumors: a 10-year experience. Neurosurgery 63:244–256, discussion 256PubMedCrossRef
20.
Zurück zum Zitat Galen (1968) Galen on the usefulness of the parts of the body. (Peri Chreias Morion.) (De Usu Partium.) Cornell University Press, Ithaca, NY Galen (1968) Galen on the usefulness of the parts of the body. (Peri Chreias Morion.) (De Usu Partium.) Cornell University Press, Ithaca, NY
21.
Zurück zum Zitat Geranmayeh F, Ashkan K (2008) Mind on canvas: anatomy, signs and neurosurgery in art. Br J Neurosurg 22:1–12PubMedCrossRef Geranmayeh F, Ashkan K (2008) Mind on canvas: anatomy, signs and neurosurgery in art. Br J Neurosurg 22:1–12PubMedCrossRef
22.
23.
Zurück zum Zitat Greenblatt SH (1997) Harvey Cushing and the issue of surgical subspecialization: an historical perspective. Surg Neurol 47:412–413PubMedCrossRef Greenblatt SH (1997) Harvey Cushing and the issue of surgical subspecialization: an historical perspective. Surg Neurol 47:412–413PubMedCrossRef
24.
Zurück zum Zitat Grosvenor AE, Laws ER (2008) The evolution of extracranial approaches to the pituitary and anterior skull base. Pituitary 11:337–345PubMedCrossRef Grosvenor AE, Laws ER (2008) The evolution of extracranial approaches to the pituitary and anterior skull base. Pituitary 11:337–345PubMedCrossRef
25.
Zurück zum Zitat Guiot G, Rougerie J, Brion S (1958) L’uitilisation des amplificateurs de brillance en neuro-radiologie et dans la chirurgie stéréotaxique. Ann Chir 23:689 Guiot G, Rougerie J, Brion S (1958) L’uitilisation des amplificateurs de brillance en neuro-radiologie et dans la chirurgie stéréotaxique. Ann Chir 23:689
26.
Zurück zum Zitat Guiot J, Rougerie J, Fourestier M, Fournier A, Comoy C, Vulmiere J, Groux R (1963) Intracranial endoscopic explorations. Presse Med 71:1225–1228PubMed Guiot J, Rougerie J, Fourestier M, Fournier A, Comoy C, Vulmiere J, Groux R (1963) Intracranial endoscopic explorations. Presse Med 71:1225–1228PubMed
27.
Zurück zum Zitat Hardy J (1965) Transsphenoidal surgery of pituitary fossa tumors with televised radiofluoroscopic control. J Neurosurg 23:612–619PubMedCrossRef Hardy J (1965) Transsphenoidal surgery of pituitary fossa tumors with televised radiofluoroscopic control. J Neurosurg 23:612–619PubMedCrossRef
29.
Zurück zum Zitat Hirschmann A (1903) Uber Endoskopie der Nase und deren Nebenhohlen. Arch Laryngol Rhinol (Berl) 14:194–202 Hirschmann A (1903) Uber Endoskopie der Nase und deren Nebenhohlen. Arch Laryngol Rhinol (Berl) 14:194–202
30.
Zurück zum Zitat Horsley V (1906) On the technique of operations on the central nervous system. BMJ 2:411–423CrossRef Horsley V (1906) On the technique of operations on the central nervous system. BMJ 2:411–423CrossRef
31.
Zurück zum Zitat Hughes J (2007) Sir Victor Horsley (1857–1916) and the birth of English neurosurgery. J Med Biogr 15:45–52PubMed Hughes J (2007) Sir Victor Horsley (1857–1916) and the birth of English neurosurgery. J Med Biogr 15:45–52PubMed
32.
Zurück zum Zitat Jane JA Jr, Han J, Prevedello DM, Jagannathan J, Dumont AS, Laws ER Jr (2005) Perspectives on endoscopic transsphenoidal surgery. Neurosurg Focus 19:E2PubMed Jane JA Jr, Han J, Prevedello DM, Jagannathan J, Dumont AS, Laws ER Jr (2005) Perspectives on endoscopic transsphenoidal surgery. Neurosurg Focus 19:E2PubMed
33.
Zurück zum Zitat Jane JJA, Thapar K, Laws JER (2002) A history of pituitary surgery. Oper Tech Neurosurg 5:200–209CrossRef Jane JJA, Thapar K, Laws JER (2002) A history of pituitary surgery. Oper Tech Neurosurg 5:200–209CrossRef
34.
Zurück zum Zitat Jankowski R, Auque J, Simon C, Marchal JC, Hepner H, Wayoff M (1992) Endoscopic pituitary tumor surgery. Laryngoscope 102:198–202PubMedCrossRef Jankowski R, Auque J, Simon C, Marchal JC, Hepner H, Wayoff M (1992) Endoscopic pituitary tumor surgery. Laryngoscope 102:198–202PubMedCrossRef
37.
Zurück zum Zitat Jho HD, Carrau RL, Ko Y, Daly MA (1997) Endoscopic pituitary surgery: an early experience. Surg Neurol 47:213–222, discussion 222–213PubMedCrossRef Jho HD, Carrau RL, Ko Y, Daly MA (1997) Endoscopic pituitary surgery: an early experience. Surg Neurol 47:213–222, discussion 222–213PubMedCrossRef
39.
Zurück zum Zitat Kennedy DW (1985) Functional endoscopic sinus surgery. Technique Arch Otolaryngol 111:643–649 Kennedy DW (1985) Functional endoscopic sinus surgery. Technique Arch Otolaryngol 111:643–649
40.
Zurück zum Zitat Linder TE, Simmen D, Stool SE (1997) Revolutionary inventions in the 20th century. The history of endoscopy. Arch Otolaryngol Head Neck Surg 123:1161–1163PubMed Linder TE, Simmen D, Stool SE (1997) Revolutionary inventions in the 20th century. The history of endoscopy. Arch Otolaryngol Head Neck Surg 123:1161–1163PubMed
42.
Zurück zum Zitat Lindholm J (2007) A century of pituitary surgery: Schloffer’s legacy. Neurosurgery 61:865–867, discussion 867–868PubMedCrossRef Lindholm J (2007) A century of pituitary surgery: Schloffer’s legacy. Neurosurgery 61:865–867, discussion 867–868PubMedCrossRef
43.
44.
Zurück zum Zitat Liu JK, Cohen-Gadol AA, Laws ER Jr, Cole CD, Kan P, Couldwell WT (2005) Harvey Cushing and Oskar Hirsch: early forefathers of modern transsphenoidal surgery. J Neurosurg 103:1096–1104PubMedCrossRef Liu JK, Cohen-Gadol AA, Laws ER Jr, Cole CD, Kan P, Couldwell WT (2005) Harvey Cushing and Oskar Hirsch: early forefathers of modern transsphenoidal surgery. J Neurosurg 103:1096–1104PubMedCrossRef
45.
Zurück zum Zitat Liu JK, Das K, Weiss MH, Laws ER Jr, Couldwell WT (2001) The history and evolution of transsphenoidal surgery. J Neurosurg 95:1083–1096PubMedCrossRef Liu JK, Das K, Weiss MH, Laws ER Jr, Couldwell WT (2001) The history and evolution of transsphenoidal surgery. J Neurosurg 95:1083–1096PubMedCrossRef
46.
Zurück zum Zitat Lower R (1963) De Catarrhis, 1672. Dawsons of Pall Mall London Lower R (1963) De Catarrhis, 1672. Dawsons of Pall Mall London
47.
48.
Zurück zum Zitat Marie P (1886) Sur deux cas d’acromégalie: hypertrophie singulière, non congénitale, des extrémités supérieures, inférieures et céphalique. Rev Med Liege 6:297–333 Marie P (1886) Sur deux cas d’acromégalie: hypertrophie singulière, non congénitale, des extrémités supérieures, inférieures et céphalique. Rev Med Liege 6:297–333
49.
Zurück zum Zitat Mehta RP, Cueva RA, Brown JD, Fliss DM, Gil Z, Kassam AB, Rassekh CH, Schlosser RJ, Snyderman CH, Har-El G (2006) What’s new in skull base medicine and surgery? Skull Base Committee Report. Otolaryngol Head Neck Surg 135:620–630PubMedCrossRef Mehta RP, Cueva RA, Brown JD, Fliss DM, Gil Z, Kassam AB, Rassekh CH, Schlosser RJ, Snyderman CH, Har-El G (2006) What’s new in skull base medicine and surgery? Skull Base Committee Report. Otolaryngol Head Neck Surg 135:620–630PubMedCrossRef
50.
Zurück zum Zitat Messerer M, De Battista JC, Raverot G, Kassis S, Dubourg J, Lapras V, Trouillas J, Perrin G, Jouanneau E (2011) Evidence of improved surgical outcome following endoscopy for nonfunctioning pituitary adenoma removal. Neurosurg Focus 30:E11PubMedCrossRef Messerer M, De Battista JC, Raverot G, Kassis S, Dubourg J, Lapras V, Trouillas J, Perrin G, Jouanneau E (2011) Evidence of improved surgical outcome following endoscopy for nonfunctioning pituitary adenoma removal. Neurosurg Focus 30:E11PubMedCrossRef
51.
Zurück zum Zitat Okudera H, Takemae T, Kobayashi S (1993) Intraoperative computed tomographic scanning during transsphenoidal surgery: technical note. Neurosurgery 32:1041–1043PubMedCrossRef Okudera H, Takemae T, Kobayashi S (1993) Intraoperative computed tomographic scanning during transsphenoidal surgery: technical note. Neurosurgery 32:1041–1043PubMedCrossRef
52.
Zurück zum Zitat Pearce JM (2002) Pituitary tumours and acromegaly (Pierre Marie’s disease). J Neurol Neurosurg Psychiatry 73:394PubMedCrossRef Pearce JM (2002) Pituitary tumours and acromegaly (Pierre Marie’s disease). J Neurol Neurosurg Psychiatry 73:394PubMedCrossRef
53.
Zurück zum Zitat Pollock JR, Akinwunmi J, Scaravilli F, Powell MP (2003) Transcranial surgery for pituitary tumors performed by Sir Victor Horsley. Neurosurgery 52:914–925, discussion 925–916PubMedCrossRef Pollock JR, Akinwunmi J, Scaravilli F, Powell MP (2003) Transcranial surgery for pituitary tumors performed by Sir Victor Horsley. Neurosurgery 52:914–925, discussion 925–916PubMedCrossRef
55.
Zurück zum Zitat Powell M (2009) Microscope and endoscopic pituitary surgery. Acta Neurochir (Wien) 151:723–728CrossRef Powell M (2009) Microscope and endoscopic pituitary surgery. Acta Neurochir (Wien) 151:723–728CrossRef
56.
57.
Zurück zum Zitat Rodziewicz GS, Chuang WC (1995) Endoscopic removal of organized chronic subdural hematoma. Surg Neurol 43:569–572, discussion 572–563PubMedCrossRef Rodziewicz GS, Chuang WC (1995) Endoscopic removal of organized chronic subdural hematoma. Surg Neurol 43:569–572, discussion 572–563PubMedCrossRef
58.
59.
Zurück zum Zitat Schloffer H (1907) Successful transnasal operation on a pituitary tumor. Wien Med Wochenschr 20:621–623 Schloffer H (1907) Successful transnasal operation on a pituitary tumor. Wien Med Wochenschr 20:621–623
60.
Zurück zum Zitat Senior BA, Ebert CS, Bednarski KK, Bassim MK, Younes M, Sigounas D, Ewend MG (2008) Minimally invasive pituitary surgery. Laryngoscope 118:1842–1855PubMedCrossRef Senior BA, Ebert CS, Bednarski KK, Bassim MK, Younes M, Sigounas D, Ewend MG (2008) Minimally invasive pituitary surgery. Laryngoscope 118:1842–1855PubMedCrossRef
61.
Zurück zum Zitat Sethi DS, Pillay PK (1995) Endoscopic management of lesions of the sella turcica. J Laryngol Otol 109:956–962PubMed Sethi DS, Pillay PK (1995) Endoscopic management of lesions of the sella turcica. J Laryngol Otol 109:956–962PubMed
62.
Zurück zum Zitat Stammberger H (1984) Endoscopic surgical treatment of mycoses of the paranasal sinuses. Laryngol Rhinol Otol (Stuttg) 63:48–55CrossRef Stammberger H (1984) Endoscopic surgical treatment of mycoses of the paranasal sinuses. Laryngol Rhinol Otol (Stuttg) 63:48–55CrossRef
63.
Zurück zum Zitat Stammberger H (1985) Personal endoscopic operative technic for the lateral nasal wall–an endoscopic surgery concept in the treatment of inflammatory diseases of the paranasal sinuses. Laryngol Rhinol Otol (Stuttg) 64:559–566CrossRef Stammberger H (1985) Personal endoscopic operative technic for the lateral nasal wall–an endoscopic surgery concept in the treatment of inflammatory diseases of the paranasal sinuses. Laryngol Rhinol Otol (Stuttg) 64:559–566CrossRef
64.
Zurück zum Zitat Stammberger H (1986) Nasal and paranasal sinus endoscopy. A diagnostic and surgical approach to recurrent sinusitis. Endoscopy 18:213–218PubMedCrossRef Stammberger H (1986) Nasal and paranasal sinus endoscopy. A diagnostic and surgical approach to recurrent sinusitis. Endoscopy 18:213–218PubMedCrossRef
65.
Zurück zum Zitat Tan TC, Black PM (2002) Sir Victor Horsley (1857–1916): pioneer of neurological surgery. Neurosurgery 50:607–611, discussion 611–602PubMed Tan TC, Black PM (2002) Sir Victor Horsley (1857–1916): pioneer of neurological surgery. Neurosurgery 50:607–611, discussion 611–602PubMed
66.
Zurück zum Zitat Teichman SL, Aldea PA (1985) Pioneers in pituitary physiology: Harvey Cushing and Nicolas Paulescu. J Hist Med Allied Sci 40:68–72PubMedCrossRef Teichman SL, Aldea PA (1985) Pioneers in pituitary physiology: Harvey Cushing and Nicolas Paulescu. J Hist Med Allied Sci 40:68–72PubMedCrossRef
67.
Zurück zum Zitat Thanabalasingham G, Karavitaki N, Cudlip S, Wass JA (2005) Treatment of pituitary tumors: history. Endocrine 28:3–8PubMedCrossRef Thanabalasingham G, Karavitaki N, Cudlip S, Wass JA (2005) Treatment of pituitary tumors: history. Endocrine 28:3–8PubMedCrossRef
68.
Zurück zum Zitat Toni R (2000) Ancient views on the hypothalamic-pituitary-thyroid axis: an historical and epistemological perspective. Pituitary 3:83–95PubMedCrossRef Toni R (2000) Ancient views on the hypothalamic-pituitary-thyroid axis: an historical and epistemological perspective. Pituitary 3:83–95PubMedCrossRef
69.
Zurück zum Zitat Walker DG, Kaye AH (2003) Image guidance and trans-sphenoidal surgery: past, present and future. J Clin Neurosci 10:289–292PubMedCrossRef Walker DG, Kaye AH (2003) Image guidance and trans-sphenoidal surgery: past, present and future. J Clin Neurosci 10:289–292PubMedCrossRef
70.
Zurück zum Zitat Walker DG, Ohaegbulam C, Black PM (2002) Frameless stereotaxy as an alternative to fluoroscopy for transsphenoidal surgery: use of the InstaTrak-3000 and a novel headset. J Clin Neurosci 9:294–297PubMedCrossRef Walker DG, Ohaegbulam C, Black PM (2002) Frameless stereotaxy as an alternative to fluoroscopy for transsphenoidal surgery: use of the InstaTrak-3000 and a novel headset. J Clin Neurosci 9:294–297PubMedCrossRef
Metadaten
Titel
Pituitary surgery: legacies from the past
verfasst von
Julie Dubourg
Emmanuel Jouanneau
Mahmoud Messerer
Publikationsdatum
01.12.2011
Verlag
Springer Vienna
Erschienen in
Acta Neurochirurgica / Ausgabe 12/2011
Print ISSN: 0001-6268
Elektronische ISSN: 0942-0940
DOI
https://doi.org/10.1007/s00701-011-1107-1

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