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Erschienen in:
01.03.2010
Plasma IL-17A Is Increased in New-Onset SLE Patients and Associated with Disease Activity
Erschienen in: Journal of Clinical Immunology | Ausgabe 2/2010
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Objective
To investigate the role of interleukin-17A (IL-17A) and Th17 cell in the pathogenesis of systemic lupus erythematosus (SLE), we studied the plasma IL-17A and the expression of Th17 cell transcription factor RORγt in Chinese new-onset SLE patients.
Methods
Sixty SLE patients aged between 18 and 40 years and 56 age-matched healthy volunteers were involved in the study. Enzyme-linked immunosorbent assay was used to measure plasma IL-17A level, and rea1-time fluorescent quantitative polymerase chain reaction was used to measure RORγt mRNA.
Results
The results showed that both IL-17A level and RORγt mRNA in SLE patients were higher than that of controls. Correlation analysis indicated that plasma IL-17A level was positively correlated with Systemic Lupus Erythematosus Disease Activity Index, not with RORγt mRNA.
Conclusion
We concluded that IL-17A might play a role in the pathogenesis of SLE and associated with disease activity. RORγt-determined Th17 cell might be involved with increased IL-17A in SLE but not exclusively the unique source.