Erschienen in:
23.01.2017 | Letter to the Editor
Platelets, Micro-Particles and Elastase. A Review with Extrapolation to the Mechanism of Generation and Bio-Pathology of Platelet Fragments
verfasst von:
L. Robert, J. Labat-Robert
Erschienen in:
Pathology & Oncology Research
|
Ausgabe 2/2017
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Excerpt
Over the recent years it was realized that cells, among them transformed cells, can be degraded to yield “micro-particles” (MP-s) which on their turn can penetrate other cells, inducing modifications, among them malignant transformation [
1,
2]. Similar results were described for blood platelets (BP-s). They also can be degraded to yield micro-particles exhibiting original biological properties which will be succinctly reviewed. Some years ago, working on BP-s, our team identified a neutral, elastase-type endopeptidase which was then intensively studied in collaboration with the team of Prof. J. Caen at the Hayem Institute in the Saint Louis Hospital Medical School in Paris. We shall review some of the characteristics of this enzyme and propose for it an active role in the production of platelet-derived micro-particles. Finally, we shall discuss the biological and pathological processes, especially in the vessel wall during atherogenesis, where these platelet-derived micro-particles may well play an important role. …
