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Erschienen in: Rheumatology International 6/2012

01.06.2012 | Case Report

Pneumonia in a patient with familial Mediterranean fever successfully treated with anakinra—case report and review

verfasst von: Stefanie Hennig, Keywan Bayegan, Martin Uffmann, Florian Thalhammer, Stefan Winkler

Erschienen in: Rheumatology International | Ausgabe 6/2012

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Abstract

We report the case of a 35-years-old renal transplant patient known to have familial Mediterranean fever with serum amyloid A (SAA)-amyloidosis, who presented with his second episode of bilateral pneumonia. As antimicrobials failed to control the first episode of pneumonia and all studies done were non-contributory, we attributed the condition to the highly active Mediterranean fever presumably resistant to colchicine and treated the patient with the interleukin-1 receptor antagonist anakinra: the patient substantially improved by clinical symptoms, chemistry and radiological evidence within no more than 2 days and was discharged in good health after 4 days.
Literatur
1.
Zurück zum Zitat Lachmann HJ, Sengul B, Yavuzsen TU (2006) Clinical and subclinical inflammation in patients with familial Mediterranean fever and in heterozygous carriers of MEFV mutations. Rheumatology 45:746–750PubMedCrossRef Lachmann HJ, Sengul B, Yavuzsen TU (2006) Clinical and subclinical inflammation in patients with familial Mediterranean fever and in heterozygous carriers of MEFV mutations. Rheumatology 45:746–750PubMedCrossRef
3.
Zurück zum Zitat The International FMF Consortium (1997) Ancient missense mutations in a new member of the RoRet gene family are likely to cause familial Mediterranean fever. Cell 90:797–807CrossRef The International FMF Consortium (1997) Ancient missense mutations in a new member of the RoRet gene family are likely to cause familial Mediterranean fever. Cell 90:797–807CrossRef
4.
Zurück zum Zitat The French FMF Consortium (1997) A candidate gene for familial Mediterranean fever. Nat General 17:25–31CrossRef The French FMF Consortium (1997) A candidate gene for familial Mediterranean fever. Nat General 17:25–31CrossRef
5.
Zurück zum Zitat Livneh A, Langevitz P (2000) Diagnostic and treatment concerns in familial Mediterranean fever. Baillieres Best Pract Res Clin Rheumatol 14:477–498PubMedCrossRef Livneh A, Langevitz P (2000) Diagnostic and treatment concerns in familial Mediterranean fever. Baillieres Best Pract Res Clin Rheumatol 14:477–498PubMedCrossRef
6.
Zurück zum Zitat Chae JJ, Wood G, Richard K, Jaffe H, Colburn NT, Masters SL, Gumucio DL, Shoham NG, Kastner DL (2008) The familial Mediterranean fever protein, pyrin, is cleaved by caspase-1 and activates NF-kB through ist N-terminal fragment. Blood 112:1794–1803PubMedCrossRef Chae JJ, Wood G, Richard K, Jaffe H, Colburn NT, Masters SL, Gumucio DL, Shoham NG, Kastner DL (2008) The familial Mediterranean fever protein, pyrin, is cleaved by caspase-1 and activates NF-kB through ist N-terminal fragment. Blood 112:1794–1803PubMedCrossRef
7.
Zurück zum Zitat Ilfeld DN, Mazar A, Garty M, Fink G, Spitzer S, Pecht M, Netzer L, Trainin N, Kuperman O (1986) Effect of oral colchicine on T cell subsets, monocytes and concanavalin A-induced suppressor cell function in asthmatic patients. Clin Allergy 16:407–416PubMedCrossRef Ilfeld DN, Mazar A, Garty M, Fink G, Spitzer S, Pecht M, Netzer L, Trainin N, Kuperman O (1986) Effect of oral colchicine on T cell subsets, monocytes and concanavalin A-induced suppressor cell function in asthmatic patients. Clin Allergy 16:407–416PubMedCrossRef
8.
Zurück zum Zitat Chae JJ, Wood G, Masters SL, Richard K, Park G, Smith BJ, Kastner DL (2006) The B30.2 domain of pyrin, the familial Mediterranean fever protein, interacts directly with caspase-1 to modulate IL-1beta production. Proc Natl Acad Sci USA 103:9982–9987PubMedCrossRef Chae JJ, Wood G, Masters SL, Richard K, Park G, Smith BJ, Kastner DL (2006) The B30.2 domain of pyrin, the familial Mediterranean fever protein, interacts directly with caspase-1 to modulate IL-1beta production. Proc Natl Acad Sci USA 103:9982–9987PubMedCrossRef
9.
Zurück zum Zitat Kineret® (anakinra) (2008) Prescribing information, medical information connection US, 2008 Amgen Kineret® (anakinra) (2008) Prescribing information, medical information connection US, 2008 Amgen
10.
Zurück zum Zitat Bresnihan B (2001) The safety and efficacy of interleukin-1 receptor antagonist in the treatment of rheumatoid arthritis. Semin Arthritis Rheum 30:17–20PubMedCrossRef Bresnihan B (2001) The safety and efficacy of interleukin-1 receptor antagonist in the treatment of rheumatoid arthritis. Semin Arthritis Rheum 30:17–20PubMedCrossRef
11.
Zurück zum Zitat Roldan R, Ruiz AM, Miranda MD, Collantes E (2008) Anakinra: new therapeutic approach in children with Familial Mediterranean Fever resistant to colchicine. Joint Bone Spine 75:504–505PubMedCrossRef Roldan R, Ruiz AM, Miranda MD, Collantes E (2008) Anakinra: new therapeutic approach in children with Familial Mediterranean Fever resistant to colchicine. Joint Bone Spine 75:504–505PubMedCrossRef
12.
Zurück zum Zitat Kuijk LM, Govers AM, Frenkel J, Hofhuis WJ (2007) Effective treatment of a colchicine-resistant familial Mediterranean fever patient with anakinra. Ann Rheum Dis 66:1545PubMedCrossRef Kuijk LM, Govers AM, Frenkel J, Hofhuis WJ (2007) Effective treatment of a colchicine-resistant familial Mediterranean fever patient with anakinra. Ann Rheum Dis 66:1545PubMedCrossRef
13.
Zurück zum Zitat Calligaris L, Marchetti F, Tommasini A, Ventura A (2008) The efficacy of anakinra in an adolescent with colchicine-resistant familial Mediterranean fever. Eur J Pediatr 167:695–696PubMedCrossRef Calligaris L, Marchetti F, Tommasini A, Ventura A (2008) The efficacy of anakinra in an adolescent with colchicine-resistant familial Mediterranean fever. Eur J Pediatr 167:695–696PubMedCrossRef
14.
Zurück zum Zitat Gattringer R, Lagler H, Gattringer KB, Knapp S, Burgmann H, Winkler S, Graninger W, Thalhammer F (2007) Anakinra in two adolescent female patients suffering from colchicine-resistant familial Mediterranean fever: effective but risky. Eur J Clin Invest 37:912–914PubMedCrossRef Gattringer R, Lagler H, Gattringer KB, Knapp S, Burgmann H, Winkler S, Graninger W, Thalhammer F (2007) Anakinra in two adolescent female patients suffering from colchicine-resistant familial Mediterranean fever: effective but risky. Eur J Clin Invest 37:912–914PubMedCrossRef
15.
Zurück zum Zitat Moser C, Pohl G, Haslinger I, Knapp S, Rowczenio D, Russel T, Lachmann HJ, Lang U, Kovarik J (2009) Successful treatment of Familial Mediterranean fever with Anakinra and outcome after renal transplantation. Nephrol Dial Transplant 24:676–678PubMedCrossRef Moser C, Pohl G, Haslinger I, Knapp S, Rowczenio D, Russel T, Lachmann HJ, Lang U, Kovarik J (2009) Successful treatment of Familial Mediterranean fever with Anakinra and outcome after renal transplantation. Nephrol Dial Transplant 24:676–678PubMedCrossRef
Metadaten
Titel
Pneumonia in a patient with familial Mediterranean fever successfully treated with anakinra—case report and review
verfasst von
Stefanie Hennig
Keywan Bayegan
Martin Uffmann
Florian Thalhammer
Stefan Winkler
Publikationsdatum
01.06.2012
Verlag
Springer-Verlag
Erschienen in
Rheumatology International / Ausgabe 6/2012
Print ISSN: 0172-8172
Elektronische ISSN: 1437-160X
DOI
https://doi.org/10.1007/s00296-010-1429-y

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