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Drugs
Erschienen in: Drugs 2/2020

01.02.2020 | Review Article

Poly (ADP-ribose) Polymerase Inhibition in Patients with Breast Cancer and BRCA 1 and 2 Mutations

verfasst von: Yolanda Jerez, Ivan Márquez-Rodas, Inmaculada Aparicio, Manuel Alva, Miguel Martín, Sara López-Tarruella

Erschienen in: Drugs | Ausgabe 2/2020

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Abstract

The poly-(ADP-ribose) polymerase (PARP) inhibitors olaparib and talazoparib, have recently been approved for use in patients with metastatic breast cancer (BC) and germline BRCA 1 or 2 mutations due to improved progression-free survival compared to chemotherapy. An increasing number of clinical trials are evaluating the role of PARP inhibitors (PARPi) in BC, alone and in combination with other therapies (including immunotherapy), as well as in earlier stages of the disease. This review describes the unique mechanism of action of these drugs and puts into clinical context the results of pivotal clinical trials. We also discuss the future development of PARPi in BC, their potential combination with other strategies, including chemotherapy and immune-checkpoint inhibitors, and the impact of these treatments in current genetic counselling.
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Metadaten
Titel
Poly (ADP-ribose) Polymerase Inhibition in Patients with Breast Cancer and BRCA 1 and 2 Mutations
verfasst von
Yolanda Jerez
Ivan Márquez-Rodas
Inmaculada Aparicio
Manuel Alva
Miguel Martín
Sara López-Tarruella
Publikationsdatum
01.02.2020
Verlag
Springer International Publishing
Erschienen in
Drugs / Ausgabe 2/2020
Print ISSN: 0012-6667
Elektronische ISSN: 1179-1950
DOI
https://doi.org/10.1007/s40265-019-01235-5

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