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01.05.2013 | Educational Series - Blue Series

Polymorphisms in HIF-1alpha affect presence of lymph node metastasis and can influence tumor size in squamous-cell carcinoma of the glottic larynx

verfasst von: F. Mera-Menéndez, A. Hinojar-Gutiérrez, M. Guijarro Rojas, J. García de Gregorio, E. Mera-Menéndez, J. J. Sánchez, M. Quintanilla, L. Cerezo, C. Gamallo

Erschienen in: Clinical and Translational Oncology | Ausgabe 5/2013

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Abstract

Background

HIF-1alpha plays a key role in the development and progression of cancer. Its polymorphic variants C1772T and G1790A have been associated with greater susceptibility to cancer and increased tumor progression.

Methods

We determined the distribution of these polymorphisms among 121 patients with glottic cancer and 154 healthy volunteers by PCR–RFLP. We also analyzed the relationship between the presence of these polymorphisms and various clinicopathologic variables.

Results

Advanced tumors (T3–T4) were associated with the TT variant (p = 0.036), which was present in 75 % of T4 tumors (p = 0.008).

Among patients with nodal metastasis (N+), 41.7 and 22 % were carrying the TT and GA variants, respectively, compared with 9.4 and 2 % of the patients with no metastasis (N0), (p = 0.006 and p = 0.032).

Conclusions

The presence of the TT and GA variants were associated with lymph node metastasis, while the presence of the TT variant can be associated with larger tumor size.

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Parkin DM, Whelan SL, Ferlay J, Storm H (2005) Cancer incidence in five continents: vol. I, to VIII. IARC Cancer Base, No 7, Lyon

Almadori G, Bussu F, Cadoni G, Galli J, Paludetti G, Maurizi M (2005) Molecular markers in laryngeal squamous cell carcinoma: towards an integrated clinicobiological approach. Eur J Cancer 41:683–693PubMedCrossRef

Bartsch H, Dally H, Popanda O, Risch A, Schmezer P (2007) Genetic risk profiles for cancer susceptibility and therapy response. Recent Results Cancer Res 174:19–36PubMedCrossRef

Vaupel P, Mayer A, Höckel M (2004) Tumor hypoxia and malignant progression. Methods Enzymol 381:335–354PubMedCrossRef

Acker T, Plate KH (2002) A role for hypoxia and hypoxia-inducible transcription factors in tumor physiology. J Mol Med 80:562–575PubMedCrossRef

Hirota K, Semenza G (2006) Regulation of angiogénesis by hypoxia-inducible factor I. Crit Rev Oncol Hematol 59:15–26PubMedCrossRef

Tanimoto K, Yoshiga K, Eguchi H, Kaneyasu M, Ukon K (2003) Hypoxia-inducible factor-1 alpha polymorphisms associated with enhanced transactivation capacity, implying clinical significance. Carcinogenesis 24:1779–1783PubMedCrossRef

Secades P, Rodrigo J, Hermsen M, Alvarez C, Suarez C, Chiara MD (2009) Increase in gene dosage is a mechanism of HIF-1alpha constitutive expression in head and neck squamous cell carcinomas. Genes Chromosom Cancer 48:441–454PubMedCrossRef

Clifford SC, Astuti D, Hooper L, Maxwell PH, Ratcliffe PJ, Maher ER (2001) The pVHL-associated SCF ubiquitin ligase complex: molecular genetic analysis of elongin B and C, Rbx1 and HIF-1alpha in renal cell carcinoma. Oncogene 20:5067–5074PubMedCrossRef

10.

Zhao T, Lv J, Zhao J, Nzekebaloudou M (2009) Hypoxia inducible factor-1 alpha gene polymorphisms and cancer risk: a meta-analysis. J Exp Clin Cancer Res 28:159PubMedCrossRef

11.

Cancer, American Join Committee on Cancer/International Union Against. American Join Committee on Cancer (2002) 6th Edition. http://www.cancerstaging.org/

12.

Warren S, Gates O (1932) Multiple malignant tumors: a survey of literature and statistical study. Am J Cancer 51:1358–1414

13.

Fransén K, Fenech M, Fredrikson M, Dabrosin C, Söderkvist P (2006) Association between ulcerative growth and hypoxia inducible factor-1 alpha polymorphisms in colorectal cancer patients. Mol Carcinog 45:833–840PubMedCrossRef

14.

Hardy GH (1908) Mendelian proportions in a mixed population. Science 28:49–50PubMedCrossRef

15.

Weinberg W (1908) Über den Nachweis der Vererbung beim Menschen. Jahreshefle des Vereins für vaterländische Naturkunde in Württemberg 64:368–382

16.

HapMap Project (2007) CEPH population. http://www.ncbi.nih.gov/SNP/snp_ref.cgi?rs=11549465

17.

HapMap Project (2007) CEPH population. http://www.ncbi.nih.gov/SNP/snp_ref.cgi?rs=11549467

18.

Bartsch H, Hietanen E (1996) The role of individual susceptibility in cancer burden related to environmental exposure. Environ Health Perspect 104:569–577PubMed

19.

Abbasi R, Ramroth H, Becher H, Dietz A, Schmezer P, Popanda O (2009) Laryngeal cancer risk associated with smoking and alcohol consumption is modified by genetic polymorphisms in ERCC5, ERC6 and RAD23B but not polymorphisms in five other nucleotide excision repair genes. Int J Cancer 125:1431–1439PubMedCrossRef

20.

Goldgar DE, Easton DF, Cannon-Albright LA, Skolnick MH (1994) Systematic population based assessment of cancer risk in first-degree relative of cancer probands. J Natl Cancer Inst 86:1600–1608PubMedCrossRef

21.

Foulkes WD, Brunet JS, Sieh W, Black MJ, Shenouda G, Narod SA (1996) Familial risks of squamous cell carcinoma of the head and neck: retrospective case-control study. BMJ 313:716–721PubMedCrossRef

22.

Cui Y, Morgenstern H, Greenland S et al (2006) Polymorphism of xeroderma pigmentosum group G and the risk of lung cancer and squamous cell carcinoma of the oropharynx, larynx and esophagus. Int J Cancer 118:714–720PubMedCrossRef

23.

Sturgis EM, Wei Q (2002) Genetic susceptibility-molecular epidemiology of head and neck cancer. Curr Opin Oncol 14:310–317PubMedCrossRef

24.

Katsuta M, Miyashita M, Makino H et al (2005) Correlation of hypoxia inducible factor-1alpha with lymphatic metastasis via vascular endothelial growth factor-C in human esophageal cancer. Exp Mol Pathol 78:123–130PubMedCrossRef

25.

Batmunkh E, Shimada M, Morine Y et al (2010) Expression of hypoxia inducible factor -1 alpha (HIF-1alpha) in patients with gallbladder carcinoma. Int J Clin Oncol 15:59–64PubMedCrossRef

26.

Aebersold DM, Burri P, Beer KT et al (2001) Expression of hypoxia inducible factor-1alpha: a novel predictive and prognostic parameter in the radiotherapy of oropharyngeal cancer. Cancer Res 61:2911–2916PubMed

27.

Lin PY, Yu CH, Wang JT, Chiang CP et al (2008) Expression of hypoxia-inducible factor-1 alpha is significantly associated with the progression and prognosis of oral squamous cell carcinoma in Taiwan. J Oral Pathol Med 37:18–25PubMedCrossRef

28.

Muñoz-Guerra MF, Fernández-Contreras ME, Moreno AL, Martín ID, Herráez B, Gamallo C (2009) Polymorphisms in the hypoxia inducible factor 1-alpha and the impact on the prognosis of early stages of oral cancer. Ann Surg Oncol 16:2351–2358PubMedCrossRef

29.

Chen MK, Chiou H, Su SC et al (2009) The association between hypoxia inducible factor-1alpha gene polymorphisms and increased susceptibility to oral cancer. Oral Oncol 45:222–226CrossRef

Titel: Polymorphisms in HIF-1alpha affect presence of lymph node metastasis and can influence tumor size in squamous-cell carcinoma of the glottic larynx
verfasst von: F. Mera-Menéndez
A. Hinojar-Gutiérrez
M. Guijarro Rojas
J. García de Gregorio
E. Mera-Menéndez
J. J. Sánchez
M. Quintanilla
L. Cerezo
C. Gamallo
Publikationsdatum: 01.05.2013
Verlag: Springer Milan
Erschienen in: Clinical and Translational Oncology / Ausgabe 5/2013
Print ISSN: 1699-048X
Elektronische ISSN: 1699-3055
DOI: https://doi.org/10.1007/s12094-012-0930-z

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25.04.2024 | Nierenkarzinom | Nachrichten

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Polymorphisms in HIF-1alpha affect presence of lymph node metastasis and can influence tumor size in squamous-cell carcinoma of the glottic larynx

Abstract

Background

Methods

Results

Conclusions

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Springer Medizin

Abstract

Background

Methods

Results

Conclusions

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