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Irish Journal of Medical Science (1971 -)

Erschienen in:

27.03.2019 | Review Article

Polypropylene mesh and systemic side effects in inguinal hernia repair: current evidence

verfasst von: Cillian Clancy, Patrick Jordan, Paul F. Ridgway

Erschienen in: Irish Journal of Medical Science (1971 -) | Ausgabe 4/2019

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Abstract

Introduction

Increasing awareness and regulatory body attention is directed towards the insertion of synthetic material for a variety of surgical procedures. This review aims to assess current evidence regarding systemic and auto-immune effects of polypropylene mesh insertion in hernia repair.

Methods

The electronic literature on systemic and auto-immune effects associated with mesh insertion was examined.

Results

Foreign body reaction following mesh implantation initiates an acute inflammatory cellular response. Involved markers such as IL-1, IL-6, IL-10 and fibrinogen are increased in circulation in the presence of mesh but return to normal at 7 days post operatively. Oxidative degradation of implanted mesh is likely, but no evidence exists to support systemic absorption or resulting disease effects. Variable cytokine production in healthy hosts leading to unpredictable or overwhelming response to implanted biomaterial warrants further investigation. Clinical studies show no associated long-term systemic effects with mesh.

Conclusion

To date, there remains no evidence to link polypropylene mesh and systemic or auto-immune symptoms. Based on current evidence, the use of polypropylene mesh is supported.

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Titel: Polypropylene mesh and systemic side effects in inguinal hernia repair: current evidence
verfasst von: Cillian Clancy
Patrick Jordan
Paul F. Ridgway
Publikationsdatum: 27.03.2019
Verlag: Springer London
Erschienen in: Irish Journal of Medical Science (1971 -) / Ausgabe 4/2019
Print ISSN: 0021-1265
Elektronische ISSN: 1863-4362
DOI: https://doi.org/10.1007/s11845-019-02008-5

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Abstract

Introduction

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