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01.11.2010 | Original Article | Ausgabe 9/2010

Annals of Nuclear Medicine 9/2010

Positron emission tomography inter-scanner differences in dopamine D2 receptor binding measured with [11C]FLB457

Zeitschrift:
Annals of Nuclear Medicine > Ausgabe 9/2010
Autoren:
Fumitoshi Kodaka, Hiroshi Ito, Miho Shidahara, Harumasa Takano, Hidehiko Takahashi, Ryosuke Arakawa, Kazuhiko Nakayama, Tetsuya Suhara

Abstract

Objective

It is well known that the positron emission tomography (PET) system is subject to inter-scanner differences of regional radioactivity distribution. In the present study, the effect of inter-scanner difference of regional radioactivity on estimated binding potential (BPND) of [11C]FLB457 using the simplified reference tissue model (SRTM) was investigated.

Methods

Each of the 11 subjects was given two PET scans using [11C]FLB457, one each with both SET-3000 GCT/X (Shimadzu) and with ECAT EXACT HR+ (Siemens/CTI). In order to assess regional differences between the two scanners, estimated BPND values in six volumes of interest (VOIs) by SRTM method were compared in both individual PET space and anatomical template space after anatomical normalization. Statistical voxel-by-voxel paired t test of BPND images between SET-3000 GCT/X and ECAT EXACT HR+ was also performed.

Results

Shapes of time–activity curves of the two PET scanners were slightly different in each VOI, with estimated BPND values from ECAT EXACT HR+ appearing greater in the cerebral cortical regions and thalamus than that of SET-3000 GCT/X in both individual PET space and anatomical template space after anatomical normalization. Statistical voxel-by-voxel analysis showed similar tendency to BPND value estimation, with greater BPND values from ECAT EXACT HR+ than from SET-3000 GCT/X.

Conclusions

We demonstrated the inter-scanner differences in dopamine D2 receptor binding measured with [11C]FLB457. In particular, statistically significant differences of BPND in certain regions were observed between two PET scanners, despite the subject groups being the same. Our results suggest that we reconsider the effect of the scanner model on the measurement of receptor binding.

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