Erschienen in:
01.12.2001 | Paper Report
p38 MAPK required for IL-12 function
verfasst von:
Athanasios Mavropoulos
Erschienen in:
Arthritis Research & Therapy
|
Ausgabe 1/2000
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Excerpt
The differentiation of T cells into T helper (Th) effector cells is an essential component of adaptive immune responses, but is of particular relevance for understanding the pathogenesis of autoimmunity and chronic inflammatory diseases. As interleukin (IL)-12 has been shown to promote the differentiation of Th1 cells, this study set out to explore signalling pathways downstream of IL-12 receptor engagement that are required for interferon (IFN)-? production by activated T cells. The binding of IL-12 to its receptor has been shown to activate JAK kinases, resulting in the recruitment of Stat4; this study, however, investigated the role of mitogen-activation protein kinase (MAPK) activity in IL-12 signalling during Th1 cell differentiation. …