Background
ncRNA | KLF2 regulation | Tumor Type | Samples | KLF2 Function | Clinical Application | Year | Study |
---|---|---|---|---|---|---|---|
TUG1 | KLF2 down regulation | Hepatocellular carcinoma | 77T 77 N tissues HepG2, Hep3B, MHCC-97 H cell lines Nude mice | Tumor suppressor | Diagnosis | 2015 | Huang (15) |
ZFAS1 | KLF2 down regulation | Gastric cancer | 54T 54 N tissues BGC823, SGC7901, MGC803, AGS, HGC27 cell line Nude mice | Tumor suppressor | Diagnosis | 2017 | Nie (19) |
DLEU1 | KLF2 down regulation | Gastric cancer | 68T 68 N tissues AGS, SGC7901, MGC803, and BGC823 cell lines | Tumor suppressor | Diagnosis | 2018 | Li (20) |
LINC00202 | KLF2 down regulation | Gastric cancer | 60T 60 N tissues AGS and SGC-7901 cell lines | Tumor suppressor | Diagnosis | 2021 | Xu (40) |
LINC01296 | KLF2 down regulation | Esophageal squamous cell carcinoma | 78T 78 N tissues EC109, EC9706, and TE-1 cell lines Nude mice | Tumor suppressor | Diagnosis | 2018 | Wang (41) |
AFAP1-AS1 | KLF2 down regulation | Gastric cancer | SGC-7901 and AGS cell lines | Tumor suppressor | Diagnosis | 2020 | Yuan (42) |
MiR-32-5p | KLF2 down regulation | Oral squamous cell carcinoma | 30T 30 N tissues SCC-9, SCC-15, SCC-25, CAL-27, and Tca-8113 cell lines | Tumor suppressor | Diagnosis | 2022 | Qin (47) |
HOXA11-AS | KLF2 down regulation | Gastric cancer | BGC823, SGC7901 and AGS cell lines Nude mice | Tumor suppressor | Diagnosis | 2017 | Liu (50) |
LINC00460 | KLF2 down regulation | Colorectal cancer | 60T 60 N tissues HCT116, SW480, HT-29, and Lovo cell lines Nude mice | Tumor suppressor | Diagnosis | 2018 | Lian (58) |
L22NC03-N64E9.1 | KLF2 down regulation | Colorectal cancer | 50T 50 N tissue DLD-1, Lovo, HT-29, SW480, SW620, and HCT116 cell line | Tumor suppressor | Diagnosis | 2017 | Lian (59) |
SNHG1 | KLF2 down regulation | Colorectal cancer | 160T 80 N tissues HCT-116, HCT-8, SW-480, SW-620, DLD-1 and HT-29 cell lines Nude mice | Tumor suppressor | Diagnosis | 2018 | Xu (67) |
HOXA-AS2 | KLF2 down regulation | Colorectal cancer | 69T 69 N tissues HCT116, DLD1, SW480, SW620, HT-29 and LOVO cell lines Nude mice | Tumor suppressor | Diagnosis | 2017 | Ding (68) |
miR-25-3p | KLF2 down regulation | Colorectal cancer | 27T 27 N tissues SW480, LS174T, SW620, LOVO, and HCT116 cell lines Nude mice | Tumor suppressor | Diagnosis | 2018 | Zeng (75) |
LINC01133 | KLF2 down regulation | Non-small cell lung cancer | 68T 68 N tissues PC9, SPC-A1, NCI-H1975, H1299, and A549 cell lines Nude mice | Tumor suppressor | Diagnosis | 2016 | Zang (83) |
miR-572 | KLF2 down regulation | Non-small cell lung cancer | 46T 46 N tissues A549, H1299, PC-9, H358, and SPC-A1 cell lines | Tumor suppressor | Diagnosis | 2022 | Sun (85) |
AGAP2-AS1 | KLF2 down regulation | Non-small cell lung cancer | 80T 80 N tissues A549, PC9, SPCA1, H1975 and H1299 cell lines Nude mice | Tumor suppressor | Diagnosis | 2016 | Li (91) |
LINC00511 | KLF2 down regulation | Non-small cell lung cancer | 57T 57 N tissues A549, PC9 and H460 cell lines | Tumor suppressor | Diagnosis | 2019 | Zhu (92) |
XIST | KLF2 down regulation | Non-small cell lung cancer | 53T 53 N tissues A549, SK-MES-1, H1299, 95D, H460, H520, H1975, H157, SK-LU-1, and SPC-A-1 cell lines Nude mice | Tumor suppressor | Diagnosis | 2016 | Fang (93) |
miR-126-5p | KLF2 up regulation | Lung adenocarcinoma | 78T 78 N tissues H1975, A549 and H1650 cell lines Nude mice | Tumor suppressor | Diagnosis | 2022 | Han (94) |
FBXL19-AS1 | KLF2 down regulation | Hepatocellular cancer | 60T 60 N tissues SMMC7721 and HCCLM3 cell lines | Tumor suppressor | Diagnosis | 2021 | Chen (111) |
ANRIL | KLF2 down regulation | Hepatocellular cancer | 77T 77 N tissues HepG2, Hep3B, and MHCC-97 H cell lines BALB/c nude mice | Tumor suppressor | Diagnosis | 2015 | Huang (112) |
DUXAP8 | KLF2 down regulation | Hepatocellular carcinoma | HepG2 and Hep3 cell lines | Tumor suppressor | Diagnosis | 2019 | Jiang (113) |
IRAIN | KLF2 down regulation | Pancreatic cancer | 37T 37 N tissues AsPC-1, BxPC-3, and PANC-1 cell lines | Tumor suppressor | Diagnosis | 2016 | Lian (128) |
SNHG15 | KLF2 down regulation | Pancreatic cancer | 48T 48 N tissues AsPC-1, BxPC-3 and PANC-1 cell lines Nude mice | Tumor suppressor | Diagnosis | 2017 | Ma (129) |
DUXAP8 | KLF2 down regulation | Pancreatic cancer | 58T tissues AsPC-1, BxPC-3, and PANC-1 cell lines Athymic mice | Tumor suppressor | Diagnosis | 2018 | Lian (130) |
LINC00702 | KLF2 down regulation | Ovarian cancer | 36T 36 N tissues ES-2, SKOV-3, A2780, and HEY cell lines | Tumor suppressor | Diagnosis | 2019 | Wang (137) |
SNHG7 | KLF2 down regulation | Ovarian cancer | 30T 30 N tissues A2780, OCC1, H8710 and SK-OV3 cell lines Nude mice | Tumor suppressor | Diagnosis | 2020 | Bai (138) |
GHET1 | KLF2 down regulation | Prostate cancer | 30T 30 N tissues LNCap and C4-2 cell lines | Tumor suppressor | Diagnosis | 2019 | Zhu (143) |
LINC00665 | KLF2 down regulation | Prostate cancer | 50T 50 N tissues PC-3, DU-145, 22RV1, LNCaP cell lines Nude mice | Tumor suppressor | Diagnosis | 2021 | Xue (144) |
SNHG6 | KLF2 down regulation | Osteosarcoma | 58T 58 N tissues KHOS, MG-63, and U2OS cell lines Nude mice | Tumor suppressor | Diagnosis | 2018 | Ruan (165) |
KLF2 target gene | Tumor Type | Samples | KLF2 Function | Clinical Application | Year | Study |
---|---|---|---|---|---|---|
TGF-β/Smad down regulation | Hepatocellular carcinoma | SMMC-7721, MHCC97H, MHCC97L, and HCCLM3 cell lines | Tumor suppressor | Diagnosis | 2020 | Li (14) |
PTEN/AKT down regulation | Gastric cancer | 15T 15 N tissues HGC-27, SNU-1, SGC-7901, NCI-N87, KATOIII, AGS, MKN-28, MKN-45, BGC-823, MGC-803 and GES-1 cell lines Nude mice | Tumor suppressor | Diagnosis and prognosis | 2017 | Wang (54) |
P21 up regulation | Colon cancer | HCT116, mutp53, SW1116, and HEK293A cell lines | Tumor suppressor | Diagnosis | 2019 | Lu (66) |
HIF-1Α/ NOTCH-1 down regulation | Colorectal cancer | SW480 HT29, SW620 and HCT116 cell lines | Tumor suppressor | Diagnosis | 2017 | Wang (74) |
WEE1 down regulation | Ovarian cancer | OV167, OV177, OV202 and OV207 cell lines | Tumor suppressor | Diagnosis | 2005 | Wang (77) |
P21/ P15 up regulation | Non-small cell lung cancer | 113T 113 N tissues A549, SPC-A1, SK-MES-1, NCI-H1299, and NCI-H1650 cell lines | Tumor suppressor | Diagnosis and prognosis | 2015 | Yin (82) |
P15/ P21 up regulation | Non-small cell lung cancer | 47T 47 N tissues A549, HCC827, SK-MES-1, NCI-H1299 and NCI-H1975 cell lines | Tumor suppressor | Diagnosis and prognosis | 2017 | Jiang (84) |
Glutamine transaminase down regulation | Non-small cell lung cancer | A549, NCI-H1299 cell lines | Tumor suppressor | Diagnosis | 2020 | Xiao (99) |
Hedgehog/Gli1 down regulation | Hepatocellular carcinoma | 38T 38 N tissues L02, Chang, 7404 and Huh-7 cell lines Nude mice | Tumor suppressor | Diagnosis | 2019 | Lin (104) |
C-Myc up regulation | Hepatocellular carcinoma | 60T 60 N tissues HuH-7 and HepG2 cell lines Nude mice | Oncogene | Diagnosis | 2016 | Zou (114) |
B-Catenin/TCF down regulation | Pancreatic cancer | 52T 52 N tissues BXPC3 and Suit2 cell lines | Tumor suppressor | Diagnosis | 2016 | Zhang (127) |
P21 up regulation | Pancreatic cancer | HPAC and SW1990 cell lines Nude mice | Tumor suppressor | Diagnosis | 2020 | Yuedi (131) |
P16, P21, And P27 up regulation and CCND1/ Survivin down regulation | Breast cancer | 20T 20 N tissues MCF10A, MCF-7, T47D, SK-BR-3, CAL-51 and MDA-MB-231cell lines | Tumor suppressor | Diagnosis | 2022 | Zhu (136) |
MMP2 down regulation | Prostate cancer | 30T 30 N tissues PC-3 and 22Rv1 cell lines | Tumor suppressor | Diagnosis | 2019 | Wang (142) |
IRF4 up regulation | Multiple myeloma | 3T tissues RPMI8226, MM.1 S and U266 cell lines | Oncogene | Diagnosis | 2016 | Ohguchi (154) |