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06.10.2018 | Original Article – Clinical Oncology

Pre-treatment metabolic tumor volume predicts tumor metastasis and progression in high-grade salivary gland carcinoma

Zeitschrift:
Journal of Cancer Research and Clinical Oncology
Autoren:
Turki M. Almuhaimid, Won Sub Lim, Jong-Lyel Roh, Jungsu S. Oh, Jae Seung Kim, Soo-Jong Kim, Seung-Ho Choi, Soon Yuhl Nam, Sang Yoon Kim
Wichtige Hinweise

Electronic supplementary material

The online version of this article (https://​doi.​org/​10.​1007/​s00432-018-2760-z) contains supplementary material, which is available to authorized users.
Turki M. Almuhaimid and Won Sub Lim contributed equally to this study.

Abstract

Purpose

High-grade salivary gland carcinoma (SGC) shows a high rate of metastasis and post-treatment recurrence, resulting in poor patient survival. Therefore, we evaluated the utility of pre-treatment 18F-FDG PET/CT parameters in predicting metastasis, tumor progression, and survival of high-grade SGC patients.

Methods

This observational study included 75 patients with previously untreated high-grade SGC who underwent pre-treatment 18F-FDG PET/CT scanning and subsequent treatment. Standardized uptake values (SUV), metabolic tumor volume (MTV), and total lesion glycolysis (TLG) were measured on pre-treatment 18F-FDG PET/CT. Logistic regression analysis was used to identify the relationship of these factors with metastasis. Cox proportional hazard regression analyses were used to identify associations between PET parameters and both progression-free survival (PFS) and overall survival (OS).

Results

A total of 36 (48%) patients had neck or distant metastases at initial staging. After controlling for clinical factors, MTV (> 8.8 mL) was an independent factor for initial metastasis (adjusted odds ratio 4.80, 95% confidence interval 1.09–21.20; P = 0.039). All PET parameters of SUVmax (> 4.3), SUVmean (> 3.0), SUVpeak (3.9), MTV (> 8.8 mL), and TLG (> 31.1 g) were significant variables for PFS (all P < 0.05), while MTV and TLG were significant factors for OS. After controlling for clinicopathological factors, MTV (adjusted hazard ratio 4.36, 95% confidence interval 1.69–11.26; P = 0.002) and TLG (3.41, 1.47–7.91; P = 0.004) were significantly associated with PFS, but not OS.

Conclusions

MTV is useful among quantitative PET measurements for predicting initial metastasis and PFS in patients with high-grade SGC.

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Zusatzmaterial
Supplementary Figure S1. Measurement of standardized uptake value (SUV) and metabolic tumor volume (MTV). The region of interest (circled) was set to include high grade salivary gland carcinoma (SGC) with metabolic activity, and software automatically calculated the SUVmax, SUVmean, SUVpeak and MTV. Total lesion glycolysis (TLG) was calculated as MTV × SUVmean. A 52-year old male patient (A) died of disease at 21 months after chemoradiotherapy for T4N2M1 salivary duct carcinoma, whereas 50-year old male patient (B) has been disease-free for 134 months since surgery plus radiotherapy for T2N0M0 high-grade carcinoma ex pleomorphic adenoma in the parotid gland. (TIF 3996 KB)
432_2018_2760_MOESM1_ESM.tif
Supplementary material 2 (DOCX 19 KB)
432_2018_2760_MOESM2_ESM.docx
Literatur
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