Erschienen in:
12.08.2019 | Original Article
Prediction of clinical outcome by controlling nutritional status (CONUT) before allogeneic hematopoietic stem cell transplantation in myeloid malignancies
verfasst von:
Hiroaki Araie, Yuka Kawaguchi, Motohito Okabe, Yoonha Lee, Marie Ohbiki, Masahide Osaki, Miyo Goto, Tatsunori Goto, Takanobu Morishita, Yukiyasu Ozawa, Koichi Miyamura
Erschienen in:
International Journal of Hematology
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Ausgabe 5/2019
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Abstract
Malnutrition before allogeneic hematopoietic cell transplantation (allo-HCT) is associated with poor clinical outcomes. Herein, we evaluated the predictive value of controlling nutritional status (CONUT) in patients undergoing allo-HCT for myeloid malignancies. We retrospectively analyzed 200 patients with myeloid malignancies who underwent allo-HCT for the first time. We evaluated CONUT before the initiation of conditioning and compared malnourished patients (poor CONUT, n = 56) with non-malnourished patients (normal CONUT, n = 144). The cumulative incidence of non-relapse mortality within 100 days (early NRM) was significantly higher in the poor CONUT group than in the normal CONUT group [21.4% (95% CI: 11.8–33.0%) vs. 9.7% (95% CI: 5.6–15.2%); P = 0.025]. In multivariate analysis, poor CONUT was an independent and significant risk factor for early NRM [HR: 2.2 (95% CI: 1.0–4.7); P = 0.048]. The overall 1-year survival rate was significantly lower in the poor CONUT group than in the normal CONUT group [53.3% (95% CI: 39.4–65.4%) vs. 71.0% (95% CI: 62.7–77.7%); P = 0.005]. These findings suggest that CONUT before allo-HCT is a useful predictor of poor outcomes in patients with myeloid malignancies.