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08.09.2016 | Retinal Disorders | Ausgabe 3/2017

Graefe's Archive for Clinical and Experimental Ophthalmology 3/2017

Predictive factors for functional improvement following intravitreal bevacizumab injections after central retinal vein occlusion

Zeitschrift:
Graefe's Archive for Clinical and Experimental Ophthalmology > Ausgabe 3/2017
Autoren:
Kai Januschowski, Nicolas Feltgen, Amelie Pielen, Bernhard Spitzer, Matus Rehak, Georg Spital, Spyridon Dimopoulos, Carsten H. Meyer, Gesine B. Szurman, Bevacizumab Study Group Venous Occlusion

Abstract

Purpose

Vision loss in central retinal vein occlusion (CRVO) is mostly caused by macular edema (ME) and can be treated with intravitreal bevacizumab injections. The goal of this study was to identify predictive factors for improvement in visual acuity.

Methods

Three hundred and sixteen eyes of six centres having received intravitreal bevacizumab for ME due to CRVO were enrolled in this multicentre, retrospective, interventional case series. The follow-up time was 24 to 48 weeks. Investigated patient characteristics were pretreatment, duration of CRVO prior to the first injection, initial best-corrected visual acuity (BCVA), baseline central retinal thickness as measured by optical coherence tomography, gender, eye, age, comorbidity with glaucoma, systemic hypertension, or diabetes mellitus.

Results

Multiple regression analysis confirmed the following baseline predictive factors for an increase in visual acuity: low BCVA (p < 0.001), high CRT (p < 0.02), and treatment naïve patients (p = 0.03). None of the other investigated patient characteristics could be identified as prognostic factors for increase in visual acuity (p > 0.1).

Conclusions

Intravitreal injections of bevacizumab in a routine clinical setting effectively improved and stabilized BCVA in CRVO. Our large multicenter study identified initial BCVA, baseline CRT, and pre-treatment as prognostic factors for visual improvement.

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Rechtliche Aspekte der Qualitätssicherung

Beispiel der intravitrealen operativen Injektionstherapie