Background
Methods
Definition of KD
Definition of IVIG-resistant and CALs
Statistical analysis
Results
The basic demographic characteristics (Table 1)
complete KD | incomplete KD |
p
| |
---|---|---|---|
M/F | 247/163 | 103/47 | NS |
Age(months)* | 25(13–47.25) | 21.5(10.75–40.25) | NS |
IVIG-resistant, n (%) | 30(7.32%) | 26(17.33%) |
p<0.01 |
CALs, n (%) | 95(23.17%) | 58(38.67%) |
p<0.01 |
Predictors for IVIG-resistance
complete KD |
p
| incomplete KD |
p
| |||||||
---|---|---|---|---|---|---|---|---|---|---|
[n] IVIG-resistant | [n] IVIG-responsive | [n] IVIG-resistant | [n]IVIG-responsive | |||||||
WBC (×109/L) | [29] | 18.69 ± 6.74 | [380] | 14.15 ± 5.67 | 0.001 | [25] | 20.17 ± 9.63 | [148] | 14.35 ± 5.94 | 0.000 |
N % | [30] | 73.88 ± 14.36 | [379] | 63.62 ± 16.71 | 0.001 | [25] | 73.19 ± 16.43 | [146] | 59.97 ± 16.76 | 0.000 |
HB (g/L) | [30] | 104.43 ± 12.48 | [375] | 108.03 ± 10.40 | 0.134 | [25] | 100.56 ± 12.00 | [147] | 109.53 ± 12.55 | 0.002 |
CRP (mg/L) | [29] | 115.58 ± 48.87 | [370] | 82.08 ± 51.71 | 0.001 | [25] | 97.00 ± 50.49 | [144] | 66.70 ± 49.60 | 0.010 |
ESR (mm/h) | [29] | 81.55 ± 31.15 | [353] | 65.81 ± 29.59 | 0.013 | [24] | 91.13 ± 35.27 | [141] | 63.22 ± 30.00 | 0.001 |
ALB (g/L) | [25] | 30.33 ± 4.89 | [339] | 35.91 ± 4.29 | 0.000 | [21] | 32.67 ± 5.34 | [131] | 37.39 ± 4.31 | 0.001 |
NT-proBNP (pg/ml) | [23] | 2192(607–4505) | [314] | 512.5(210.5-1195.5) | 0.000 | [14] | 775.(296.5–1780.75) | [104] | 300.5(107.25–925) | 0.094 |
IL-6 (pg/ml) | [21] | 68.10(38.7–221.35) | [302] | 29.55(10.45-93.25) | 0.003 | [17] | 130.70(20.90–491.05) | [103] | 11.90(5.07-50.58) | 0.001 |
IL-10 (pg/ml) | [21] | 14.40(5.25–60.05) | [302] | 6.50(4.00–12.23) | 0.006 | [17] | 12.10(4.8–45.6) | [103] | 4.75(3.18–8.75) | 0.001 |
Cutoff | OR |
p
| Sensitivity, % | Specificity, % | PPV, % | NPV, % |
---|---|---|---|---|---|---|
(95% CI) | (95% CI) | (95% CI) | (95% CI) | (95% CI) | ||
WBC( × 109 L) | ||||||
>13.18 | 7.803(2.327–26.161) | 0.001 | 89.66(69.44–94.50) | 46.32(41.36–51.34) | 11.3(7.83–16.05) | 98.32(95.19–99.43) |
>16 | 3.002(1.412–6.385) | 0.004 | 55.17(37.55–71.59) | 69.47(64.67–73.89) | 12.12(7.6–18.78) | 95.31(92.14–97.24) |
>20 | 4.524(2.017–10.145) | 0.000 | 37.93(22.69–56) | 88.68(85.1–91.49) | 20.37(11.77–32.9) | 94.9(92.13–96.77) |
N (%) | ||||||
>70 | 2.341(1.096–5.001) | 0.028 | 60(42.32–75.41) | 60.42(55.42–65.22) | 10.71(6.89–16.3) | 95.02(91.5–97.13) |
>80 | 4.561(2.117–9.83) | 0.000 | 46.67(30.23–63.86) | 83.91(79.87–87.26) | 18.67(11.46–28.93) | 95.2(92.36–97.03) |
CRP(mg/L) | ||||||
>70 | 4.402(1.644–11.786) | 0.003 | 82.76(65.45–92.4) | 47.84(42.8–52.92) | 11.06(7.55–15.93) | 97.2(93.73–98.82) |
>100 | 3.231(1.46–7.15) | 0.004 | 65.52(47.35–80.06) | 62.7(57.67–67.48) | 12.1(7.89–18.13) | 95.8(92.56–97.74) |
ESR (mm/h) | ||||||
>50 | 2.441(0.908–6.559) | 0.077 | 82.76(65.45–92.4) | 33.71(28.98–38.79) | 9.3(6.33–13.47) | 95.9(90.91–98.27) |
>100 | 2.438(1.055–5.634) | 0.037 | 31.03(17.28–49.23) | 84.42(80.27–87.83) | 14.06(7.58–24.62) | 93.7(90.49–95.89) |
ALB (g/L) | ||||||
<32 | 11.719(4.689–29.288) | 0.000 | 72(52.42–85.72) | 83.19(78.84–86.79) | 24(15.75–34.78) | 97.5(95.09–98.82) |
NT–proBNP(pg/ml) | ||||||
>1300 | 9.189(3.496–24.156) | 0.000 | 73.91(53.53–87.45) | 76.43(71.44–80.79) | 18.68(12–27.9) | 97.5(94.78–98.88) |
IL–6 (pg/ml) | ||||||
>30 | 6.243(1.801–21.637) | 0.004 | 85.71(65.36–95.02) | 50.99(45.38–56.58) | 10.84(6.97–16.49) | 98.0(94.53–99.35) |
>45 | 5.131(1.831–14.381) | 0.002 | 76.19(54.91–89.37) | 61.59(55.99–66.9) | 12.12(7.6–18.78) | 97.3(94.02–98.88) |
>200 | 2.309(0.798–6.683) | 0.123 | 23.81(10.63–45.09) | 88.08(83.94–91.26) | 12.2(5.32–25.54) | 94.3(90.98–96.48) |
IL–10 (pg/ml) | ||||||
>5 | 2.614(0.858–7.96) | 0.091 | 80.95(60–92.33) | 38.08(32.79–43.67) | 8.33(5.27–12.94) | 96.6(91.68–98.69) |
>30 | 6.533(2.481–17.201) | 0.001 | 38.1(20.75–59.12) | 91.39(87.68–94.06) | 23.53(12.44–40) | 95.5(92.46–97.35) |
Cutoff | OR |
p
| Sensitivity, % | Specificity, % | PPV, % | NPV, % |
---|---|---|---|---|---|---|
(95% CI) | (95% CI) | (95% CI) | (95% CI) | (95% CI) | ||
WBC ( × 109/L) | ||||||
>17.56 | 6.032(2.406–15.12) | 0.000 | 64(44.52–79.75) | 77.24(69.07–83.75) | 36.3(23.78–51.13) | 91.35(84.37–95.38) |
>20 | 5.053(2.004–12.736) | 0.000 | 48(30.03–66.5) | 84.55(77.13–89.88) | 38.7(23.73–56.18) | 88.8(81.91–93.39) |
N (%) | ||||||
>70 | 4.303(1.712–10.817) | 0.002 | 68(48.41–82.79) | 66.94(58.15–74.69) | 29.8(19.53–42.66) | 91.0(83.25–95.37) |
>80 | 8.721(3.142–24.21) | 0.000 | 44(26.67–62.93) | 91.74(85.45–95.45) | 52.3(32.37–71.66) | 88.8(82.08–93.21) |
HB (g/L) | ||||||
<110 | 5.25(1.702–16.197) | 0.004 | 80(60.87–91.14) | 54.1(45.27–62.68) | 26.3(17.73–37.18) | 92.9(84.55–96.95) |
CRP (mg/L) | ||||||
>70 | 3.804(1.476–9.803) | 0.006 | 72(52.42–85.72) | 59.66(50.68–68.04) | 27.27(18–39.04) | 91.0(82.62–95.58) |
>100 | 3.776(1.548–9.209) | 0.003 | 56(37.07–73.33) | 74.79(66.3–81.73) | 31.82(20–46.56) | 89(81.37–93.75) |
ESR (mm/h) | ||||||
>80 | 4.675(1.791–12.204) | 0.002 | 70.83(50.83–85.09) | 65.81(56.84–73.78) | 29.8(19.53–42.66) | 91.67(83.78–95.9) |
>100 | 8.154(2.955–22.499) | 0.000 | 45.83(27.89–64.93) | 90.6(83.95–94.67) | 50(30.72–69.28) | 89.08(82.2–93.5) |
ALB (g/L) | ||||||
<32 | 7.5(2.543–22.117) | 0.000 | 42.86(24.47–63.45) | 92.73(86.3–96.27) | 52.9(30.96–73.83) | 89.47(82.5–93.88) |
NT–proBNP (pg/ml) | ||||||
>360 | 4.795(1.252–18.366) | 0.022 | 78.57(52.41–92.43) | 56.67(46.36–66.42) | 22(12.75–35.24) | 94.4(84.89–98.09) |
>1300 | 2.000(0.553–7.231) | 0.29 | 28.57(11.72–54.65) | 83.33(74.31–89.63) | 21.05(8.51–43.33) | 88.2(79.68–93.48) |
IL–6 (pg/ml) | ||||||
>15 | 9.474(2.04–43.995) | 0.004 | 88.24(65.66–96.71) | 55.81(45.29–65.84) | 28.3(17.97–41.57) | 96(86.54–98.9) |
>25 | 4.717(1.516–14.676) | 0.007 | 70.59(46.87–86.72) | 66.28(55.78–75.38) | 29.2(17.61–44.48) | 91.9(82.47–96.51) |
>120 | 15(4.242–53.042) | 0.000 | 52.94(30.96–73.83) | 93.02(85.6–96.76) | 60(35.75–80.18) | 90.9(83.07–95.32) |
IL–10 (pg/ml) | ||||||
>8 | 5.333(1.764–16.125) | 0.003 | 64.71(41.3–82.69) | 74.42(64.29–82.46) | 33.3(19.75–50.39) | 91.4(82.53–96.01) |
>30 | 8.542(2.008–36.328) | 0.001 | 29.41(13.28–53.13) | 95.35(88.64–98.18) | 55.5(26.67–81.12) | 87.23(79-92.54) |
Predictor for CALs
complete KD |
p
| incomplete KD |
p
| |||||||
---|---|---|---|---|---|---|---|---|---|---|
[n] CALs+ | [n] CALs- | [n] CALs+ | [n] CALs- | |||||||
WBC (×109/L) | [95] | 16.61 ± 7.05 | [314] | 13.84 ± 5.31 | 0.000 | [56] | 17.31 ± 8.48 | [92] | 14.14 ± 5.67 | 0.007 |
N % | [95] | 66.84 ± 15.41 | [314] | 63.63 ± 17.08 | 0.084 | [55] | 64.28 ± 17.42 | [91] | 61.00 ± 17.35 | 0.272 |
HB (g/L) | [94] | 105.16 ± 11.96 | [311] | 108.55 ± 10.03 | 0.014 | [55] | 106.87 ± 12.90 | [92] | 108.68 ± 12.87 | 0.411 |
CRP (mg/L) | [89] | 100.00 ± 53.47 | [310] | 80.07 ± 51.03 | 0.002 | [53] | 80.44 ± 51.63 | [91] | 67.02 ± 50.09 | 0.131 |
ESR (mm/h) | [92] | 73.78 ± 32.29 | [290] | 64.85 ± 28.92 | 0.019 | [55] | 77.78 ± 33.60 | [86] | 61.70 ± 30.46 | 0.005 |
ALB (g/L) | [86] | 33.48 ± 5.02 | [278] | 36.16 ± 4.21 | 0.000 | [50] | 35.81 ± 5.09 | [81] | 37.14 ± 4.56 | 0.134 |
NT-proBNP (pg/ml) | [76] | 669.5(278.25–1583) | [261] | 497(203–1374) | 0.069 | [39] | 334(135–796) | [65] | 303(90–1101.5) | 0.869 |
IL-6 (pg/ml) | [71] | 31.80(13.90–120.20) | [252] | 30.45(10.86–94.66) | 0.590 | [37] | 19.80(4.9–63.45) | [66] | 13.35(6.70–56.33) | 0.956 |
IL-10 (pg/ml) | [71] | 6.30(3.7–13.4) | [252] | 6.70(4.20–13.13) | 0.748 | [37] | 5.80(3.35–10.80) | [66] | 5.00(3.35–12.18) | 0.921 |
Cutoff | OR |
p
| Sensitivity, % | Specificity, % | PPV, % | NPV, % |
---|---|---|---|---|---|---|
(95% CI) | (95% CI) | (95% CI) | (95% CI) | (95% CI) | ||
WBC ( × 109/L) | ||||||
>14.25 | 2.35(1.467–3.766) | 0.000 | 62.11(52.06–71.21) | 58.92(53.4–64.22) | 31.3(25.18–38.33) | 83.71(78.27–88) |
>20 | 2.416(1.321–4.421) | 0.004 | 22.11(14.94–31.44) | 89.49(85.61–92.42) | 38.8(27.04–52.21) | 79.1(74.63–83.06) |
HB (g/L) | ||||||
<110 | 1.671(1.017–2.744) | 0.043 | 68.09(58.11–76.64) | 44.37(38.95–49.93) | 27(21.75–32.99) | 82.14(75.65–87.2) |
<100 | 2.217(1.334–3.684) | 0.002 | 30.85(22.42–40.79) | 82.96(78.38–86.73) | 35.3(25.89–46.16) | 79.8(75.16–83.89) |
CRP (mg/L) | ||||||
>25 | 3.308(1.278–8.561) | 0.014 | 94.38(87.51–97.58) | 16.45(12.74–20.98) | 24.4(20.24–29.31) | 91.0(80.74–96.13) |
>140 | 1.913(1.113–3.29) | 0.019 | 29.21(20.78–39.36) | 82.26(77.62–86.11) | 32.1(22.94–42.88) | 80.19(75.46–84.2) |
ESR (mm/h) | ||||||
>75 | 2.038(1.268–3.276) | 0.003 | 53.26(43.14–63.12) | 64.14(58.47–69.44) | 32.0(25.15–39.78) | 81.2(75.67–85.75) |
ALB (g/L) | ||||||
<30 | 3.003(1.596–5.651) | 0.001 | 23.26(15.59–33.21) | 90.65(86.65–93.54) | 43.4(30.21–57.75) | 79.2(74.45–83.34) |
Cutoff | OR |
p
| Sensitivity, % | Specificity, % | PPV, % | NPV, % |
---|---|---|---|---|---|---|
(95% CI) | (95% CI) | (95% CI) | (95% CI) | (95% CI) | ||
WBC ( × 109/L) | ||||||
>14.25 | 1.545(0.787–3.033) | 0.206 | 60.71(47.63–72.42) | 50(39.99–60.01) | 42.5(32.26–53.43) | 67.65(55.84–77.56) |
>20 | 4.091(1.777–9.419) | 0.001 | 35.71(24.46–48.81) | 88.04(79.85–93.19) | 64.5(46.95–78.88) | 69.2(60.37–76.87) |
HB (g/L) | ||||||
<110 | 1.676(0.845–3.323) | 0.14 | 63.64(50.42–75.07) | 32.61(23.89–42.72) | 36.08(27.22–46) | 60(46.18–72.39) |
<100 | 1.231(0.582–2.603) | 0.587 | 27.27(17.28–40.23) | 76.09(66.44–83.64) | 40.5(26.35–56.51) | 63.6(54.33–72.02) |
CRP (mg/L) | ||||||
>25 | 2.373(0.988–5.7) | 0.053 | 84.91(72.95–92.15) | 29.67(21.26–39.72) | 41.2(32.49–50.67) | 77.1(60.98–87.93) |
>140 | 2.386(0.917–6.209) | 0.075 | 20.75(12–33.46) | 90.11(82.26–94.71) | 55(34.21–74.18) | 66.1(57.43–73.86) |
ESR (mm/h) | ||||||
>75 | 3.022(1.498–6.097) | 0.002 | 61.82(48.61–73.48) | 65.12(54.59–74.35) | 53.1(41.07–64.82) | 72.7(61.88–81.42) |
ALB (g/L) | ||||||
<30 | 2.474(0.74–8.273) | 0.141 | 14(6.95–26.19) | 93.83(86.35–97.33) | 58.3(31.95–80.67) | 63.8(54.93–71.94) |