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Journal of Genetic Counseling

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06.06.2016 | Review Paper

Predispositions to Lymphoma: A Practical Review for Genetic Counselors

verfasst von: Morgan Similuk, V. Koneti Rao, Jane Churpek, Michael Lenardo

Erschienen in: Journal of Genetic Counseling | Ausgabe 6/2016

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Abstract

This review provides a synopsis for genetic counselors of the major concepts of lymphoma predisposition: genomic instability, immune deficiency, inappropriate lymphoproliferation, and chronic antigen stimulation. We discuss syndromes typifying each of these mechanisms. Importantly, our review of the genetic counseling literature reveals sparse discussion of genetically-based immune-mediated lymphoma predisposition, which we address in depth here. We aim to increase awareness among genetic counselors and colleagues in oncology about familial susceptibility and facilitate critical thinking about lymphoma risk assessment. Clinical application of this knowledge is aided by recommendations for collection of personal and family history to guide risk assessment and testing. Lastly, we include a special discussion of genetic counseling issues including perceptions of the context, nature, and magnitude of lymphoma risk, as well as coping with awareness of susceptibility to lymphoma.

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Titel: Predispositions to Lymphoma: A Practical Review for Genetic Counselors
verfasst von: Morgan Similuk
V. Koneti Rao
Jane Churpek
Michael Lenardo
Publikationsdatum: 06.06.2016
Verlag: Springer US
Erschienen in: Journal of Genetic Counseling / Ausgabe 6/2016
Print ISSN: 1059-7700
Elektronische ISSN: 1573-3599
DOI: https://doi.org/10.1007/s10897-016-9979-0

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