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Journal of Natural Medicines

Erschienen in:

24.09.2018 | Original Paper

Pregnane glycosides from the bark of Marsdenia cundurango and their cytotoxic activity

verfasst von: Satoru Tatsuno, Akihito Yokosuka, Fusako Hatsuma, Yuto Mashiko, Yoshihiro Mimaki

Erschienen in: Journal of Natural Medicines | Ausgabe 1/2019

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Abstract

Seven new pregnane glycosides (1–7) and eight known compounds (8–15) were isolated from the bark of Marsdenia cundurango (Asclepiadaceae). The structures of 1–7 were determined by spectroscopic analysis, including two-dimension NMR spectroscopy, chemical transformations, and chromatographic analysis of the hydrolyzed products. The isolated compounds 1–15 were evaluated for their cytotoxic activity against HL-60 human leukemia cells, A549 human lung adenocarcinoma cells, and TIG-3 normal human lung cells, including apoptosis-inducing activity of a representative pregnane glycoside in HL-60 cells.

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Titel: Pregnane glycosides from the bark of Marsdenia cundurango and their cytotoxic activity
verfasst von: Satoru Tatsuno
Akihito Yokosuka
Fusako Hatsuma
Yuto Mashiko
Yoshihiro Mimaki
Publikationsdatum: 24.09.2018
Verlag: Springer Singapore
Erschienen in: Journal of Natural Medicines / Ausgabe 1/2019
Print ISSN: 1340-3443
Elektronische ISSN: 1861-0293
DOI: https://doi.org/10.1007/s11418-018-1248-0

Springer Medizin

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