nach oben

Cancer Immunology, Immunotherapy

Erschienen in:

01.03.2005 | Original Article

Preoperative mannan-binding lectin pathway and prognosis in colorectal cancer

verfasst von: Henriette Ytting, Ib Jarle Christensen, Jens Christian Jensenius, Steffen Thiel, Hans Jørgen Nielsen

Erschienen in: Cancer Immunology, Immunotherapy | Ausgabe 3/2005

Einloggen, um Zugang zu erhalten

Abstract

Purpose: Deficiency of the mannan-binding lectin (MBL) pathway of innate immunity is associated with increased susceptibility to infections. In patients with colorectal cancer (CRC), postoperative infection is associated with poor prognosis. The aim of the present study was to evaluate (1) the relation between the MBL pathway and postoperative infectious complications and survival of patients resected for CRC, and (2) the role of MBL in acute phase response compared to C-reactive protein (CRP). Methods: Preoperative MBL concentration, MBL-associated serine protease (MBL/MASP) activity and CRP were determined in serum from 611 patients and 150 healthy controls. The patients were observed for 8 years. Postoperative infections, recurrence and survival were recorded. Results: The MBL pathway components were increased in the patients compared with the healthy controls (p<0.0001). Low MBL levels were predictive of pneumonia (p=0.01), and pneumonia (n=87) was associated with poor survival (p=0.003; HR=1.5; 95% CI, 1.1 to 1.9). MBL and MBL/MASP activity showed no correlation with CRP (Spearman’s ρ=0.02; 95% CI, −0.06 to 0.10). Conclusion: Low preoperative MBL levels are predictive of pneumonia, which is associated with poorer survival. MBL concentration and MBL/MASP activity was not predictive of other postoperative infections or long-term prognosis, and showed no correlation with CRP.

Aittoniemi J, Rintala E, Miettinen A et al (1997) Serum mannan-binding lectin (MBL) in patients with infection: clinical and laboratory correlates. APMIS 105:617–622PubMed

Faist E (1996) The mechanisms of host defense dysfunction following shock and trauma. Curr Top Microbiol Immunol 216:259–274PubMed

Fujita S, Teramoto T, Watanabe M et al (1993) Anastomotic leakage after colorectal cancer surgery: a risk factor for recurrence and poor prognosis. Jpn J Clin Oncol 23:299–302PubMed

Garred P, Thiel S, Madsen HO et al (1992) Gene frequency and partial protein characterization of an allelic variant of mannan binding protein associated with low serum concentrations. Clin Exp Immunol 90:517–521PubMed

Garred P, Strom J, Quist L et al (2003) Association of mannose-binding lectin polymorphisms with sepsis and fatal outcome, in patients with systemic inflammatory response syndrome. J Infect Dis 188:1394–1403CrossRefPubMed

Grandis JR, Snyderman CH, Johnson JT et al (1992) Postoperative wound infection: a poor prognostic sign for patients with head and neck cancer. Cancer 70:2166–2170

Herroeder S, Durieux ME, Hollmann MW (2002) Inflammatory responses after surgery. Hosp Med 63:99–103PubMed

Holmskov U, Thiel S, Jensenius JC (2003) Collections and ficolins: humoral lectins of the innate immune defense. Annu Rev Immunol 21:547–578CrossRefPubMed

Jackson RM, Rice DH (1990) Wound infections and recurrence in head and neck cancer. Otolaryngol Head Neck Surg 102:331–333PubMed

10.

Johnson HL, Chiou CC, Cho CT (1999) Applications of acute phase reactants in infectious diseases. J Microbiol Immunol Infect 32:73–82PubMed

11.

Kakkanaiah VN, Shen GQ, Ojo-Amaize EA et al (1998) Association of low concentrations of serum mannose-binding protein with recurrent infections in adults. Clin Diagn Lab Immunol 5:319–321PubMed

12.

Kehlet H, Nielsen HJ (1998) Impact of laparoscopic surgery on stress responses, immunofunction, and risk of infectious complications. New Horiz 6:S80–S88PubMed

13.

Kilpatrick DC (2002) Mannan-binding lectin and its role in innate immunity. Transfus Med 12:335–352CrossRefPubMed

14.

Kressner U, Graf W, Mahteme H et al (2002) Septic complications and prognosis after surgery for rectal cancer. Dis Colon Rectum 45:316–321CrossRefPubMed

15.

Lipscombe RJ, Sumiya M, Hill AV et al (1992) High frequencies in African and non-African populations of independent mutations in the mannose binding protein gene. Hum Mol Genet 1:709–715PubMed

16.

Liu H, Jensen L, Hansen S et al (2001) Characterization and quantification of mouse mannan-binding lectins (MBL-A and MBL-C) and study of acute phase responses. Scand J Immunol 53:489–497CrossRefPubMed

17.

Mannick JA, Rodrick ML, Lederer JA (2001) The immunologic response to injury. J Am Coll Surg 193:237–244CrossRefPubMed

18.

McMillan DC, Wotherspoon HA, Fearon KC et al (1995) A prospective study of tumor recurrence and the acute-phase response after apparently curative colorectal cancer surgery. Am J Surg 170:319–322CrossRefPubMed

19.

McMillan DC, Elahi MM, Sattar N et al (2001) Measurement of the systemic inflammatory response predicts cancer-specific and non-cancer survival in patients with cancer. Nutr Cancer 41:64–69CrossRefPubMed

20.

McMillan DC, Canna K, McArdle CS (2003) Systemic inflammatory response predicts survival following curative resection of colorectal cancer. Br J Surg 90:215–219CrossRefPubMed

21.

McMillan DC, Canna K, McArdle CS (2003) The effect of deprivation and the systemic inflammatory response on outcome following curative resection for colorectal cancer. Br J Cancer 89:612–614CrossRefPubMed

22.

Mynster T, Christensen IJ, Moesgaard F et al (2000) Effects of the combination of blood transfusion and postoperative infectious complications on prognosis after surgery for colorectal cancer. Danish RANX05 Colorectal Cancer Study Group. Br J Surg 87:1553–1562

23.

Neth O, Hann I, Turner MW et al (2001) Deficiency of mannose-binding lectin and burden of infection in children with malignancy: a prospective study. Lancet 358:614–618CrossRefPubMed

24.

Nielsen HJ, Christensen IJ, Moesgaard F et al (2002) Ranitidine as adjuvant treatment in colorectal cancer. Br J Surg 89:1416–1422CrossRefPubMed

25.

Nozoe T, Matsumata T, Kitamura M et al (1998) Significance of preoperative elevation of serum C-reactive protein as an indicator for prognosis in colorectal cancer. Am J Surg 176:335–338CrossRefPubMed

26.

Nozoe T, Matsumata T, Sugimachi K (2000) Preoperative elevation of serum C-reactive protein is related to impaired immunity in patients with colorectal cancer. Am J Clin Oncol 23:263–266PubMed

27.

Petersen S, Freitag M, Hellmich G et al (1998) Anastomotic leakage: impact on local recurrence and survival in surgery of colorectal cancer. Int J Colorectal Dis 13:160–163CrossRefPubMed

28.

Petersen SV, Thiel S, Jensen L et al (2001) An assay for the mannan-binding lectin pathway of complement activation. J Immunol Methods 257:107–116CrossRefPubMed

29.

Petersen SV, Thiel S, Jensenius JC (2001) The mannan-binding lectin pathway of complement activation: biology and disease association. Mol Immunol 38:133–149CrossRefPubMed

30.

Peterslund NA, Koch C, Jensenius JC et al (2001) Association between deficiency of mannose-binding lectin and severe infections after chemotherapy. Lancet 358:637–638CrossRefPubMed

31.

Rasmussen LA, Nielsen HJ, Sorensen S et al (1995) Ranitidine reduces postoperative interleukin-6 induced C-reactive protein synthesis. J Am Coll Surg 181:138–144PubMed

32.

Rodrigo JP, Suarez C (1998) Prognostic significance of postoperative wound infection on head and neck cancer. Otolaryngol Head Neck Surg 118:272–275PubMed

33.

Siassi M, Hohenberger W, Riese J (2003) Mannan-binding lectin (MBL) serum levels and post-operative infections. Biochem Soc Trans 31:774–775CrossRefPubMed

34.

Summerfield JA, Sumiya M, Levin M et al (1997) Association of mutations in mannose binding protein gene with childhood infection in consecutive hospital series. Br Med J 314:1229–1232

35.

Swisher SG, Holmes EC, Hunt KK et al (1996) Perioperative blood transfusions and decreased long-term survival in esophageal cancer. J Thorac Cardiovasc Surg 112:341–348PubMed

36.

Terai I, Kobayashi K, Fujita T et al (1993) Human serum mannose binding protein (MBP): development of an enzyme-linked immunosorbent assay (ELISA) and determination of levels in serum from 1085 normal Japanese and in some body fluids. Biochem Med Metab Biol 50:111–119CrossRefPubMed

37.

Thiel S, Holmskov U, Hviid L et al (1992) The concentration of the C-type lectin, mannan-binding protein, in human plasma increases during an acute phase response. Clin Exp Immunol 90:31–35PubMed

38.

Thiel S, Moller-Kristensen M, Jensen L et al (2002) Assays for the functional activity of the mannan-binding lectin pathway of complement activation. Immunobiology 205:446–454PubMed

39.

Wigmore SJ, McMahon AJ, Sturgeon CM et al (2001) Acute-phase protein response, survival and tumour recurrence in patients with colorectal cancer. Br J Surg 88:255–260CrossRefPubMed

40.

Windsor AC, Klava A, Somers SS et al (1995) Manipulation of local and systemic host defence in the prevention of perioperative sepsis. Br J Surg 82:1460–1467PubMed

41.

Ytting H, Jensenius JC, Christensen IJ et al (2004) Increased activity of the mannan-binding lectin complement activation pathway in patients with colorectal cancer. Scand J Gastroenterol 39:674–679CrossRefPubMed

42.

Zimmermann-Nielsen E, Baatrup G, Thorlacius-Ussing O et al (2002) Complement activation mediated by mannan-binding lectin in plasma from healthy individuals and from patients with SLE, Crohn’s disease and colorectal cancer: suppressed activation by SLE plasma. Scand J Immunol 55:105–110CrossRef

Titel: Preoperative mannan-binding lectin pathway and prognosis in colorectal cancer
verfasst von: Henriette Ytting
Ib Jarle Christensen
Jens Christian Jensenius
Steffen Thiel
Hans Jørgen Nielsen
Publikationsdatum: 01.03.2005
Verlag: Springer-Verlag
Erschienen in: Cancer Immunology, Immunotherapy / Ausgabe 3/2005
Print ISSN: 0340-7004
Elektronische ISSN: 1432-0851
DOI: https://doi.org/10.1007/s00262-004-0594-9

Springer Medizin

Preoperative mannan-binding lectin pathway and prognosis in colorectal cancer

Abstract

Neu im Fachgebiet Onkologie

Alphablocker schützt vor Miktionsproblemen nach der Biopsie

Antikörper-Wirkstoff-Konjugat hält solide Tumoren in Schach

Mammakarzinom: Senken Statine das krebsbedingte Sterberisiko?

Labor, CT-Anthropometrie zeigen Risiko für Pankreaskrebs

Update Onkologie

Springer Medizin

Abstract

Bitte loggen Sie sich ein, um Zugang zu diesem Inhalt zu erhalten

Weitere Artikel der Ausgabe 3/2005

Peptide immunisation of HLA-DR–transgenic mice permits the identification of a novel HLA-DRβ1*0101– and HLA-DRβ1*0401–restricted epitope from p53

Bridging the innate and adaptive immune responses against cancer: 95th AACR meeting 2004

A listing of human tumor antigens recognized by T cells: March 2004 update

Immunotherapy at the American Association for Cancer Research 95th annual meeting: a personal impression

Phase I study of a MUC1 vaccine composed of different doses of MUC1 peptide with SB-AS2 adjuvant in resected and locally advanced pancreatic cancer

Spontaneous T-cell responses against peptides derived from the Taxol resistance–associated gene-3 (TRAG-3) protein in cancer patients

Neu im Fachgebiet Onkologie

Alphablocker schützt vor Miktionsproblemen nach der Biopsie

Antikörper-Wirkstoff-Konjugat hält solide Tumoren in Schach

Mammakarzinom: Senken Statine das krebsbedingte Sterberisiko?

Labor, CT-Anthropometrie zeigen Risiko für Pankreaskrebs

Update Onkologie

Peptide immunisation of HLA-DR–transgenic mice permits the identification of a novel HLA-DRβ10101– and HLA-DRβ10401–restricted epitope from p53