To identify MRI characteristics that may predict the functional effect of selective dorsal rhizotomy (SDR) in children with bilateral spastic paresis.
Methods
We performed SDR in a group of 36 patients. The gross motor functioning measure-66 (GMFM-66) was applied before and after SDR. Available cerebral MRIs were retrospectively classified into three diagnostic groups: periventricular leucomalacia (PVL; n = 10), hydrocephalus (n = 2), and normal (n = 6). In patients with PVL, we scored the severity of the MR abnormalities. We compared the changes in the GMFM-66 after SDR in the diagnostic groups. In patients with PVL, we correlated the severity of the MR abnormalities with the changes in the GMFM-66.
Results
The mean follow-up period was 5 years and 4 months (range, 1 year and 1 month to 9 years). The best improvement in gross motor function was observed in patients with normal MRI, and the slightest improvement was observed in patients with hydrocephalus. The severity of the PVL did correlate with the GMFM-66 score before SDR but not with the functional effect of SDR.
Conclusion
We conclude that with respect to gross motor skills, the improvements after SDR are good in patients with no MRI abnormalities. In the patients with hydrocephalus, the improvements after SDR were insignificant. In patients with PVL, the improvements were intermediate and did not correlate with the degree of PVL.
Hinweise
This study was supported by the Phelps Foundation for Spasticity (Phelps Stichting voor Spastici, project number 1996.044), The Netherlands. During his work at this study, Sebastian Grunt was supported by grants from the Anna Müller-Grocholski Foundation, Zürich, Switzerland and the Swiss Foundation for Children with Cerebral Palsy, Berne, Switzerland.
Introduction
Spasticity is defined as a velocity-dependent increase in the tonic stretch response with excessive tendon jerk reflexes [1] and is caused by the reduction of inhibitory impulses on lower motor neurons. Spasticity can cause pain, muscle shortening, and orthopedic malformations, and it can severely interfere with functional abilities and gait pattern. Cerebral palsy (CP) is the most frequent cause of spasticity in children. Cerebral palsy is a group of disorders of movement and posture due to a nonprogressive lesion of the developing brain [2]. As a consequence of this definition, its causes are diverse.
Different treatment modalities are used to treat spasticity in children. Selective dorsal rhizotomy (SDR) is a neurosurgical treatment that is mainly performed at lumbar level in patients with bilateral spastic paresis. By incomplete transection of the (sensory) posterior lumbosacral rootlets, SDR reduces the excitatory input from the lower limbs that enters the spinal cord. In children with spastic CP, SDR leads to a more normal gait pattern [3‐6], better performance of the activities of daily life [7, 8], and improvement in gross motor function [6‐13]. Data on functional outcome after SDR in patients with other conditions than spastic CP are limited, though promising [14]. Detailed information about the clinical characteristics of the selected children, other than spasticity alone, is often lacking.
Anzeige
Medical history and clinical examination does not always provide sufficient evidence to establish the diagnosis of the underlying disorder in patients with CP. The Quality Standards Subcommittee of the American Academy of Neurology and the Practice Committee of the Child Neurology Society both advise magnetic resonance imaging (MRI) of the brain for all CP patients [15]. In patients with bilateral spastic CP, the most common MRI abnormality is periventricular leucomalacia (PVL), which is characterized by a damage of the periventricular white matter [16‐19]. Gray matter lesions, early developmental abnormalities of the central nervous system, and abnormalities of the cerebrospinal fluid space, such as hydrocephalus, are less commonly found [17‐19], and in some children with bilateral spastic CP no abnormalities are found with MRI [16‐19]. In patients with normal MRI findings and bilateral spastic paresis, genetic causes or spinal cord involvement should be considered.
The goal of this study was to identify possible relationships between the MRI findings with the level of gross motor function of the patient before SDR and the change in functioning after SDR. For this purpose, we retrospectively analyzed the MRIs of the patients who underwent SDR in our clinic.
Methods and materials
Subjects
This study was part of the project: “Investigation of long-term effects of SDR in children with spastic diplegia” and was approved by the medical ethical committee of the VU University Medical Center, Amsterdam, The Netherlands (project number 2006/105). Informed consent was given by the parents of all participants. The study population consisted of all the patients who underwent SDR in our clinic between January 1998 and December 2007. The first nine patients have been described in a previous report [8]. The patients were selected for SDR according to the criteria shown in Table 1. In our previous study, we only included patients with bilateral spastic CP and documented PVL [8]. In the present study, we included patients with nonprogressive spasticity due to different diagnoses. In our analysis, we included data on patients who underwent pre- and postoperative gross motor function measure (GMFM-66) analysis with a follow-up period of at least 12 months and of whom MRI was available for review.
Table 1
Selection criteria for selective dorsal rhizotomy in the VU University Medical Center
Criteria for selective dorsal rhizotomy
1.)
Bilateral spasticity of the lower extremities interfering with walking performance
2.)
Presence of spasticity (defined as velocity-dependent resistance to passive stretch) in at least six muscle groups of the lower limbs
3.)
Sufficient force in the quadriceps femoris muscle (squatting at least seven times) and the hip extensors (kneel with extended hips, support for balance allowed)
4.)
Absence of structural orthopedic deformities or contractures at hip, knee, or ankle
5.)
Presence of moderate to good selective motor control in the lower limbs
6.)
Gross motor function classification system (GMFCS) level I, II, or III
7.)
Good support from parents and rehabilitation setting
Procedure
Selective dorsal rhizotomy was performed by the same neurosurgeon (WVO) in all children. Dorsal roots L2-S1 were exposed and separated into different rootlets after laminotomy L2-L5 and opening of the dura. Transection of the rootlets was performed after electro-stimulation, according to palpable muscle contraction and EMG response. At most, 50% of the rootlets were transected on one level. To prevent sexual and bladder disturbances, rootlets/fascicles showing electrical response after stimulation of the penis/the clitoris were spared. Postoperative rehabilitation included intensive physical therapy for 12 months.
Anzeige
Neuroimaging
The MRIs were assessed at two different points in time by two investigators—one neuropediatrician (8 years of experience in the assessment of MR neuroimaging; RJV) and one pediatrician with specialization in pediatric neurorehabilitation (2 years of experience in the assessment of MR neuroimaging; SG). Imaging was classified into three diagnostic groups according to the following criteria: periventricular leucomalacia (PVL; increased signal intensity of the periventricular white matter in T2 weighted imaging and/or FLAIR; other abnormalities optional); hydrocephalus (signs of ventricular dilatation and increased intracranial pressure); normal MRI (see Fig. 1a–i). In one patient, the MR abnormalities could not be classified into one of the three diagnostic groups and he was excluded from further data analysis (patient number 19, Table 2; his MRI showed delayed myelinisation and slightly enlarged ventricular size but no other white matter abnormalities and there were no signs of increased intracranial pressure). In the patients with PVL, we graded the severity of their MRI abnormalities based on the work of Cioni et al. [20]. The following items were assessed: ventricular size, evidence and extension of white matter signal intensity, evidence and extension of white matter loss, thinning of the corpus callosum, dimension (size) of subarachnoidal space, evidence and size of cysts, and presence of gray matter abnormalities. We also investigated whether white matter loss was occipitally and/or frontally present. The items were scored on a three-point scale, with a score of three indicating the most severe MRI abnormalities. The scores were summed to obtain a total score for each child (minimal score, 7 and maximal score, 21). Intra- and interobserver agreement was assessed for all items. If the two investigators did not agree, the classification and/or scoring were determined by a consensus.
Fig. 1
a–i MR imaging of three patients with bilateral spastic paresis undergoing SDR. a, d, g Midsagittal T1 weighted images. b, e, h Transversal T2 weighted images at the level of the centrum semiovale. g, h, i Transversal T2 weighted imaging at the level of the basal ganglia. a–c MR images classified as “normal.” d–f MR images classified as periventricular leucomalacia showing thinning of the corpus callosum involving the total body (Fig. 1a), bilaterally increased periventricular white matter signal intensity (Fig. 1e), a slight ventricular enlargement, and a loss of the occipital white matter (Fig. 1f). g–i MR images classified as hydrocephalus. The lateral ventricles and the third and fourth ventricles (Fig. 1i) are enlarged
Table 2
Summary of the characteristics of the patients included in the study
Case
Gender
GA (weeks)
BW (g)
Age SDR years (mts)
Follow-up years (mts)
MRI classification
Diagnosis
GMFM-66 before SDR
GMFM-66 (mean) after SDR
1
F
30
2,000
5 (7)
8 (5)
PVL
PVL
50.85
53.29
2
F
40
2,500
5(7)
9 (0)
PVL
PVL
47.68
49.66
3
F
40
3,450
5 (8)
8 (11)
PVL
PVL
54.38
55.71
4
M
30
1,650
6 (8)
8 (11)
PVL
PVL
46.91
48.32
5
F
28
1,285
4 (11)
7 (10)
PVL
PVL
50.32
54.75
6
M
26
1,000
5 (3)
7 (10)
PVL
PVL
64.98
67.82
7
M
32
2,510
5 (1)
6 (7)
PVL
PVL
54.15
60.38
8
M
33
1,265
8 (9)
5 (1)
PVL
PVL
47.09
55.92
9
M
26
870
6 (11)
3 (11)
PVL
PVL
50.09
54.32
10
M
26
780
5 (4)
3 (0)
PVL
PVL
52.32
62.98
11
F
41
3,060
8 (4)
5 (2)
Hydrocephalus
Congenital hydrocephalus
55.62
56.35
12
M
27
1,020
10 (1)
4 (5)
Hydrocephalus
Congenital hydrocephalus
68.86
68.69
13
M
40
3,300
5 (9)
7 (2)
Normal
Unknown
65.33
67.31
14
M
34
3,155
6 (11)
3 (0)
Normal
Spinal process
76.75
85.15
15
M
38
4,280
8 (0)
2 (7)
Normal
Unknown
82.99
89.70
16
F
40
3,875
8 (10)
1 (7)
Normal
HIV-Encephalo(myelo)pathy
73.63
80.46
17
M
39
4,040
6 (7)
2 (0)
Normal
Unknown
65.98
78.38
18
M
40
3,460
6 (5)
1 (1)
Normal
Unknown
73.63
81.93
19
M
37
3,400
3 (11)
7 (1)
Not classified
Laurence moon syndrome
47.26
83.01
F female, M male, GA gestational age, BW birth weight, SDR selective dorsal rhizotomy, GMFCS gross motor function classification system, GMFM gross motor function measure, PVL periventricular leucomalacia, g gram, mts months
×
Outcome measure
All patients had a detailed pre- and postoperative clinical evaluation, including spasticity assessment, range of motion of single joints, gait analysis, and the GMFM. In this study, we only report the results of the GMFM. The GMFM is a criterion-referenced observational measure that was developed to assess children with CP. The validity, reliability, and responsiveness of the GMFM have been demonstrated in a population of patients similar to the participants in the present study [21]. For our data analysis, we used the GMFM-66 version, which assesses 66 items covering five gross motor dimensions (lying and rolling/crawling and kneeling/standing and walking/running/jumping) and is elaborated to a numerical scale ranging from 0 to 100.
As outcome parameters we used the mean of all postoperative GMFM-66 scores from 1 year after surgery. The changes after SDR were expressed as the difference between GMFM-66 score and the preoperative GMFM-66 score (Delta-GMFM-66).
Statistical analysis
For the reliability analysis of the MRI scoring, we used Kappa statistics. Agreement strengths for the Kappa values were classified according to Landis and Koch [22]. For the comparison of the outcome in patients with different MRI characteristics, we used nonparametric tests (Kruskal–Walis test for group comparison; post hoc analysis was performed using the Mann–Whitney test when the level of significance was reached). Correlations were assessed with the Spearman’s rank correlation coefficient. For the statistical analysis, we used SPSS® version 14.0 for Windows. Level of significance was set at 0.05.
Results
Clinical characteristics and level of functioning
Thirty-six patients underwent SDR of whom 32 patients had a brain MRI performed before SDR, and 26 MRIs were available for review. Of the patients with available MRI, four did not have any preoperative GMFM-66 assessments. Three patients had a GMFM-66 assessment before SDR but with a follow-up period of less than 12 months. The detailed patient characteristics of the remaining 19 patients are summarized in Table 2. The mean number of GMFM assessments per patient was 4.9 (standard deviation (SD) 3.5, range 1 to 12), and the mean follow-up period was 5 years and 4 months (SD 2 years and 9 months, range 1 year and 1 month to 9 years). The mean age at the time of the operation was 6 years and 10 months (SD 1 year and 6 months, range 5 years and 9 months to 10 years and1 month). The age at the time of SDR neither correlate with the preoperative GMFM-66 (rho, 0.328; p = 0.184) nor with the postoperative GMFM-66 scores (rho, 0.336; p = 0.173) and the improvement after SDR (rho, −0.049; p = 0.847). We found no difference in the Delta-GMFM-66 score between boys and girls.
Neuroimaging
We diagnosed PVL in ten patients, hydrocephalus in two patients, and no MRI abnormalities in six patients. The classification of MRIs did not differ between the two observers. With respect to the grading of the MR abnormalities, the intrarater agreement was perfect for the frontal and occipital white matter loss, cysts, thinning of the corpus callosum, subarachnoidal space, and gray matter abnormalities (Kappa, 1.0) and almost perfect for the ventricular size (Kappa, 0.90) and the white matter signal intensities (Kappa, 0.87). The interrater agreement was considerably less than the intrarater agreement. It was perfect for the subarachnoidal space and the gray matter abnormalities (Kappa, 1.0), almost perfect for the ventricular size (Kappa, 0.90), substantial for the occipital white matter loss (Kappa, 0.74), and moderate for the frontal white matter loss (Kappa, 0.45). Kappa statistics could not be calculated for the white matter signal intensities, cysts, and thinning of the corpus callosum as only one of the two observers graded severe abnormalities (according grade three on the point scale). With respect to the white matter signal intensities and the thinning of the corpus callosum, the observers disagreed in 25% of the scorings, with respect to the cysts there was a disagreement in 36%.
The outcome parameters in patients with different MRI classification are summarized in Table 3 and in Fig. 2. The preoperative GMFM-66 scores were significantly higher in patients with normal MRI than in patients with PVL (p = 0.001). Patients with hydrocephalus had intermediate scores and did not differ significantly from the other groups. In the follow-up measurements, the mean GMFM-66 was the highest in patients with a normal MRI (group difference, p = 0.003; difference between PVL and normal, p = 0.002). The patients with normal MRI also made the best postoperative improvements. Almost no improvement was observed in the patients with hydrocephalus (group difference p = 0.030; difference between PVL and hydrocephalus, p = 0.032; difference between hydrocephalus and normal MRI, p = 0.046). There was a significant group difference in age at the time of the operation (p = 0.028). Patients with normal MRI and patients with hydrocephalus were older at the time of the operation than patients with PVL—for the patients with normal MRI this difference was significant (p = 0.044).
Table 3
Differences of gross motor outcome in with patients with different MRI classification
Normal MRI (n = 6)
PVL (n = 10)
Hydrocephalus (n = 2)
Total (n = 18)
P value
Mean
SD
Range
Mean
SD
Range
Mean
SD
Range
Mean
SD
Range
GMFM-66 before SDR
73.1a
6.7
65.3–83.0
51.9a
5.3
46.9–65.0
62.2
9.4
55.6–68.9
60.1
11.5
46.9–83.0
0.002
Mean GMFM-66 after SDR
80.5a
7.6
67.3–89.7
56.3a
5.9
48.3–67.8
62.5
8.7
56.3–68.7
65.1
13.0
48.3–89.7
0.003
Delta-GMFM-66
7.4b
3.4
2.0–12.4
4.4c
3.2
1.3–10.7
0.3b, c
0.6
−0.2–0.7
5.0
3.7
−0.2–12.4
0.030
MRI magnetic resonance imaging, PVL periventricular leucomalacia, SD standard deviation, GMFM gross motor function measure
aSignificant difference with p < 0.05 (Mann–Whitney test) between normal MRI and PVL
bSignificant difference with p < 0.05 (Mann–Whitney test) between normal MRI and Hydrocephalus
cSignificant difference with p < 0.05 (Mann–Whitney test) between hydrocephalus and PVL
Fig. 2
Box plots of the preoperative GMFM-66 (white boxes) and the mean values of all postoperative GMFM-66 measurements (dashed boxes) in patients with different MRI classification. Note that the largest improvements after SDR were observed in patients with normal MRI and that the patients with hydrocephalus did not improve after SDR
×
The scoring of the MRI abnormalities in the patients with PVL is summarized in Table 4. Two patients with PVL did not show ventricular enlargement, and eight patients had moderate ventricular enlargement. All patients had moderate white matter signal intensity. Nine patients had moderate occipital white matter loss, and one patient had moderate frontal white matter loss. Small cysts were found in one patient, and large cysts were found in two. Four patients had no thinning of the corpus callosum, and six patients had moderate thinning of the corpus callosum. None of the patients had gray matter abnormalities or an enlargement of the subarachnoidal space. The mean total score was 10.8 (SD, 1.1; range, 8 to 12). The total score did not correlate with any of the outcome parameters. The ventricular size showed a significant correlation with the preoperative GMFM-66 score (rho, −0.696; p = 0.025). However, none of the items in the scoring correlated with the postoperative changes of the GMFM-66.
Table 4
Scoring of the MR abnormalities in patients with periventricular leucomalacia (n = 10)
Normal
Moderate
Severe
Ventricular size
2 (20%)
8 (80%)
0 (0%)
White matter signal intensity
0 (0%)
10 (100%)
0 (0%)
White matter loss
1 (10%)
9 (90%)
0 (0%)
Thinning of the corpus callosum
4 (40%)
6 (60%)
0 (0%)
Cysts
7 (70%)
1 (10%)
2 (20%)
Gray matter abnormality
10 (100%)
0 (0%)
0 (0%)
Enlargement of the subarachnoidal space
10 (100%)
0 (0%)
0 (0%)
Mean
SD
Range
Total Score
10.8
1.1
8–12
Anzeige
Discussion
The aim of this study was to identify possible relationships between MR characteristics and the level of functioning before and after SDR in patients with bilateral spastic paresis. We classified the MRIs in three MRI categories: PVL, hydrocephalus, and normal MRI and compared the postoperative improvement in the GMFM in the three groups. The best results were found in the group with normal MRI, and the poorest results were found in patients with hydrocephalus. The poor outcome of patients with hydrocephalus could be a consequence of persistently elevated intracranial pressure, which can be observed in the absence of characteristic symptoms in children with CP [23]. In the present study, both patients with hydrocephalus (patient 11 and patient 12) underwent surgical correction. Patient 11 had a ventriculo peritoneal shunt placed early during childhood. Patient 12 was diagnosed with hydrocephalus a few months before SDR, and he underwent third ventriculostomy. Unfortunately, there was no follow-up imaging available for either of these patients, and although neither of them showed any clinical evidence of elevated intracranial pressure, it cannot be ruled out definitively. Previous studies found greater postoperative improvements after SDR in children with less motor impairment [7, 13]. In contrast, in the three randomized controlled trials comparing functional outcome after SDR, the poorest results were found in the study which included children with the best preoperative gross motor skills [9, 10]. In the present study, the patients with normal MRI had much better preoperative gross motor skills than the patients with PVL and hydrocephalus. We found no correlation between the preoperative GMFM score and its improvement postoperatively. McLaughlin et al. found an inverse correlation between the age at the time of the operation and the postoperative changes in the GMFM [9]. This could be explained as a consequence of faster spontaneous motor development in early childhood. However, in our study, not only the children with hydrocephalus (who showed the poorest outcome), but also the children with normal MRI (who showed the best outcome) were older than the patients with PVL when SDR was performed. There was no correlation between the age at the time of SDR and outcome.
In the patients with PVL, we graded the severity of the MR abnormalities and correlated them with the gross motor abilities. For this purpose, we used a grading scale that has previously been used to describe MR abnormalities in patients with spastic CP [20, 24]. We performed a reliability analysis of the various items included in this grading scale. The agreement between investigators was substantially worse than in the Cioni et al. study in which two experienced raters scored the MRIs [20]. In the present study, the interobserver reliability was notably poor for the assessment of the cysts. Several explanations should be considered: it was difficult to detect cysts in an area with extensive gliosis, there is a difference between the level of experience with brain MRI in the two investigators (2 years vs 8 years). Only the amount of ventricular enlargement correlated with the preoperative gross motor abilities. Correlations between ventricular size and gross motor abilities have been described previously in patients with spastic CP [25]. In contrast to the findings of previous studies [20, 24, 26], we did not find a correlation between gross motor skills and the total MRI score/the thinning of the corpus callosum. However, the present study was limited to ambulatory patients with GMFCS levels I to III, and patients with more severe motor handicaps where more severe brain abnormalities could be expected on MRI have not been studied. No correlations were found between the severity of the brain anomalies and the outcome after SDR.
The outcome assessment in the present study consisted in the GMFM-66 which—according to the International Classification of Functioning, Disability, and Healths (ICF) [27]—assesses the domain of activity. However, the other two domains of the ICF—body structure and participation—have not been evaluated. One other limitation of the present study was the small sample size. Unfortunately, we did not have access to all MRI scans and not all patients had a preoperative GMFM assessment. We could only include data on a small number of patients in our analysis. Notably, the group with hydrocephalus was small and comprised only two patients. Therefore, the association between the type of brain lesion and the outcome after SDR needs to be proved in future studies with larger study samples, including the other ICF domains—body structure and participation.
Conclusion
We found significant differences in the post-operative changes in the GMFM-66 in patients with different brain MRI abnormalities. The largest postoperative improvement was observed in patients with normal MRI, and the poorest outcome was observed in patients with hydrocephalus. In patients with PVL, we could not detect any relation between MRI abnormalities and the postoperative improvement in of gross motor function after SDR. We conclude that MRI of the brain can provide additional information for the selection of patients for SDR. However, the degree of PVL does not provide information about the degree of improvement in gross motor function after SDR.
Anzeige
Acknowledgment
We are very grateful to Mrs. Maaike Schothorst, who motivated the parents and the children to participate and collected the patient data. We also wish to thank Dr. R. Strijers who performed all electrophysiological measurements during the interventions.
Open Access
This article is distributed under the terms of the Creative Commons Attribution Noncommercial License which permits any noncommercial use, distribution, and reproduction in any medium, provided the original author(s) and source are credited.
Open AccessThis is an open access article distributed under the terms of the Creative Commons Attribution Noncommercial License (https://creativecommons.org/licenses/by-nc/2.0), which permits any noncommercial use, distribution, and reproduction in any medium, provided the original author(s) and source are credited.
Mit e.Med Neurologie & Psychiatrie erhalten Sie Zugang zu CME-Fortbildungen der Fachgebiete, den Premium-Inhalten der dazugehörigen Fachzeitschriften, inklusive einer gedruckten Zeitschrift Ihrer Wahl.
Mit e.Med Neurologie erhalten Sie Zugang zu CME-Fortbildungen des Fachgebietes, den Premium-Inhalten der neurologischen Fachzeitschriften, inklusive einer gedruckten Neurologie-Zeitschrift Ihrer Wahl.
Mit e.Med Pädiatrie erhalten Sie Zugang zu CME-Fortbildungen des Fachgebietes Pädiatrie, den Premium-Inhalten der pädiatrischen Fachzeitschriften, inklusive einer gedruckten Pädiatrie-Zeitschrift Ihrer Wahl.
Nach der Katheterablation von Vorhofflimmern kommt es bei etwa einem Drittel der Patienten zu Rezidiven, meist binnen eines Jahres. Wie sich spätere Rückfälle auf die Erfolgschancen einer erneuten Ablation auswirken, haben Schweizer Kardiologen erforscht.
Schmerzen im Unterbauch, aber sonst nicht viel, was auf eine Appendizitis hindeutete: Ein junger Mann hatte Glück, dass trotzdem eine Laparoskopie mit Appendektomie durchgeführt und der Wurmfortsatz histologisch untersucht wurde.
Derzeit wird empfohlen, eine Therapie mit GLP-1-Rezeptoragonisten präoperativ zu unterbrechen. Eine neue Studie nährt jedoch Zweifel an der Notwendigkeit der Maßnahme.
Die Ureterstriktur ist eine relativ seltene Komplikation, trotzdem bedarf sie einer differenzierten Versorgung. In komplexen Fällen wird dies durch die roboterassistierte OP-Technik gewährleistet. Erste Resultate ermutigen.
Update Chirurgie
Bestellen Sie unseren Fach-Newsletterund bleiben Sie gut informiert.
Das Karpaltunnelsyndrom ist die häufigste Kompressionsneuropathie peripherer Nerven. Obwohl die Anamnese mit dem nächtlichen Einschlafen der Hand (Brachialgia parästhetica nocturna) sehr typisch ist, ist eine klinisch-neurologische Untersuchung und Elektroneurografie in manchen Fällen auch eine Neurosonografie erforderlich. Im Anfangsstadium sind konservative Maßnahmen (Handgelenksschiene, Ergotherapie) empfehlenswert. Bei nicht Ansprechen der konservativen Therapie oder Auftreten von neurologischen Ausfällen ist eine Dekompression des N. medianus am Karpaltunnel indiziert.
Das Webinar beschäftigt sich mit Fragen und Antworten zu Diagnostik und Klassifikation sowie Möglichkeiten des Ausschlusses von Zusatzverletzungen. Die Referenten erläutern, welche Frakturen konservativ behandelt werden können und wie. Das Webinar beantwortet die Frage nach aktuellen operativen Therapiekonzepten: Welcher Zugang, welches Osteosynthesematerial? Auf was muss bei der Nachbehandlung der distalen Radiusfraktur geachtet werden?
Inhalte des Webinars zur S1-Leitlinie „Empfehlungen zur Therapie der akuten Appendizitis bei Erwachsenen“ sind die Darstellung des Projektes und des Erstellungswegs zur S1-Leitlinie, die Erläuterung der klinischen Relevanz der Klassifikation EAES 2015, die wissenschaftliche Begründung der wichtigsten Empfehlungen und die Darstellung stadiengerechter Therapieoptionen.
