Prevalence and associated factors of pediatric emergency mortality at Tikur Anbessa specialized tertiary hospital: a 5 year retrospective case review study

Child mortality rates remain high globally [1] with around 3.1 million neonates, 2.3 million infants and 2.3 million childhood deaths occurring every year [2]. Mortality rates in children younger than 5 years have dropped from 11.9 million deaths in 1990 to 7.7 million deaths in 2010 [2]. Worldwide, the distribution of deaths in children fewer than five years of age is 33% in south Asia, 50% in sub-Saharan Africa, and less than 1% in high-income countries [3]. Common factors associated with childhood mortality include acute trauma, extremely preterm birth, and late presentation to the emergency units [4]. In resource-poor countries, pneumonia and diarrhea account for 20% of deaths in children fewer than 5 years old [2]. Malaria, AIDS, acute respiratory-tract infection, measles, and malnutrition were significantly contributed to child mortality [5]. In developing countries 10 to 20% of severely sick children are admitted to hospital every year [6‐8].

In Africa, the childhood mortality rate is 92 per 1000 live births which are 15 times more than that of well-resourced countries [9]. Most childhood deaths from preventable communicable diseases and malnutrition were related to poor environmental health, poverty and lack of knowledge [10].

The magnitude and severity of child mortality are exacerbated by different factors, including delays in seeking assessment and treatment, diarrhea, and poor nutritional status [11]. In pediatric departments, early child mortality is commonly caused by preventable and reversible diseases, so urgent treatment and resuscitation are required to avoid poor outcomes [12, 13]. Early identification and treatment of pneumonia, sepsis, malaria, heart failure (secondary to anemia), acute respiratory tract infections, and diarrheal diseases has been shown to reduce childhood mortality in acute pediatric hospitals [14‐17]. Effective intervention and good emergency care of children requires effort and coordination starting from the bedside up to the governmental level. Critical clinical issues, such as shortness of breath, fast breathing and fever with seizure are some of the preventable causes contributing to childhood mortality [12]. Despite advances in public health systems in Ethiopia through global partnerships, there is still a lack of well-organized pediatric emergency units. There is also limited information regarding pediatric mortality patterns, causes and associated factors [18].

Mortality rate is a reflection of the severity of illness and the quality of treatment of patients in pediatric emergency departments. The risk factors associated with the mortality of pediatric age groups in developing countries are largely unknown. This study aims to provide baseline pediatric mortality and valuable associated data essential to health care providers and administrators. This will help them allocate resources to the development of interventions, effective prevention and community education programs to reduce preventable childhood deaths in Ethiopia.

Over the five-year study period, a total of 12,240 children (7 days old to 13 years old) presented to the pediatric emergency unit; 499 (4.1%) deaths were recorded. Of these, 338 (67.7%) pediatric deaths fulfilled the criteria for analysis, while the remaining 161 (32.3%) records were excluded because of incomplete documentation.

Table 1 lists the frequency distribution of socio-demographic characteristics and clinical presenting features of the study participants. More deaths occurred in males (56.5%), with a male to female ratio of 1.3:1. The average age was 37.5(±standard deviation = 43.2) months. Nearly half of the participants came from Addis Ababa region with more than 92.6% referrals from different health institution. Half of the study patients had previously visited a hospital, and more than 90% patients had a history of a hospital admission with different medical causes. Of all the deaths analyzed for this study, only 17.8% patients had a history of previous diarrhea within last year, and around 26.9% had history of malnutrition.

Approximately 32% of deaths were documented as early death (within ≤24 h of arrival in the pediatric emergency department). More than half (59%) patients presented for treatment following at least two days of signs and/or symptoms (Table 1). In all the age groups, males were admitted more often than females (Fig. 1), with higher numbers of deaths occurring in the pre-school age and infant age group (Fig. 2). However, the highest mortality rate was seen in the neonatal age group (6%), followed by infants (2.9%), then the other age groups (Fig. 2).

The five most common presenting symptoms were fast breathing (66, 19.5%), fever (48, 14.2%), vomiting (41, 12.1%), cough (38, 11.2%), and shortness of breath (31, 9.2%) (Fig. 3).

Children presenting to our emergency department, had a mortality rate of 4.1%. The incidence of pediatric mortality in this study was lower than the previous studies conducted in Ethiopia [23‐26]. This decrease may be due to improvements in the maternal and child urban health care settings. Despite this low mortality rate, early death less than 24 h after admission 107 (31.7%) was still high albeit, lower than other studies [18, 19, 26, 27].

The majority of pediatric emergency mortality in hospitals was due to preventable diseases within 24 h of admission [12]. This may be due to poor health care seeking behavior, delay in referral, using traditional medicine, and poverty [28]. A study done in Sub-Saharan countries on care-seeking behaviors related to respiratory illness were found that only 30% of Ethiopian children with suspected pneumonia were taken to a health care settings; this was the lowest proportion in the six analyzed countries [29]. Another study identified multiple factors influencing care-seeking behaviors in Ethiopian children including lack of knowledge, delay in recognition of illness severity and household income [30]. The main causes of neonatal death were late-onset sepsis (50.9%), meningitis (24.6%), and pneumonia (10.5%). Previous studies done in Nigeria and Benin identified high rates of sepsis in this age group [20, 21, 31], which may be due to unclean cord care practices, traditional birth attendant, polluted atmosphere and poor health education among parents [32].

We found that the primary causes of death for the infant and pre-school age groups at TASTH were pneumonia, congestive heart failure, meningitis, and sepsis and hypovolemic shock. This is similar to previous work in China, Nigeria, Ghana, India and a World Health Organization (WHO) report [19, 20, 22, 33, 34]. In Ethiopia, pneumonia is an important public health problem for all children, and creates a significant burden of childhood mortality [18, 35]. A health extension program package focused on disease prevention and health education targeting antibiotic treatment for childhood pneumonia might be a solution to decrease deaths from pneumonia. However, there are some challenges in promoting a health extension program package due to knowledge gaps of health extension workers such as misdiagnosis, negligence and inappropriate referrals [36, 37]. These problems need to be addressed and improved because pneumonia contributes to the high early pediatric mortality in developing countries [38].

Our study found that congestive heart failure and hematological malignancy were top primary causes of school age group mortality. This is consistent with findings in China and Nigeria [19‐21], but quite different to other studies in Nigeria, Ethiopia and sub-Saharan Africa countries which suggested a smaller role for these conditions [26, 39, 40]. This disparity may be due to lack of cardiac and pediatric oncology services in developing countries. Many low- and middle-income countries lack pediatric cardiac care programs, resulting insignificant mortality from congenital heart diseases [41]. Other possible causes include lack of primary care, screening and health follow-up in low income countries. However, even with early diagnosis, accesses to expensive chemotherapy agents and/or specialized cardiac surgery are also severely limited.

Our study found that the most five common presenting symptoms of children who died within the PED were shortness of breath, fast breathing, fever, vomiting, and cough. Shortness of breath, fever and fast breathing were associated with early mortality when compared to the other common presenting symptom. These findings are similar to the studies found in Ghana and South East Nigeria [22, 42].

These common signs and symptoms are usually identified by emergent assessment of airway, breathing and circulation [13, 14, 43]. Consequently, immediate treatment and management is critical, particularly for airway obstruction that leads to severe illness and death when left untreated. Early triage assessment and identification of signs of critical illness, and rapid initiation of appropriate treatment should be priorities for all hospitals providing emergency care for children.

Malnutrition and diarrhea were common co-morbid conditions associated with the primary causes of death. This is consistent with studies conducted in Kenya, Ghana [22, 44] and Ethiopia [18, 26]. Additionally, in our study diarrheal disease was significantly associated with pediatric mortality. In Africa, many studies have identified diarrheal disease to be a significant cause of death in childhood [20, 22, 25, 44‐51].

Malnutrition was a co-morbid condition in one-third of pediatric deaths. Micronutrient initiative programs and multi-sector collaboration may be useful interventions to improve community awareness of the importance of balanced nutrition. However, difficulty accessing or affording food is a significant challenge for large numbers of African children [52].

Our study has potential limitations. This includes the retrospective study design, and the reliance on interpretation of documentation within the medical record. In some cases, it was difficult to obtain adequate study information. Unfortunately, we were unable to collect data on almost one-third of all cases due to incomplete documentation (95, 19.1%) of the patient’s medical history, loss of the medical chart (66, 13.2%) and one patient who had multiple diagnoses recorded, rendering it difficult to identify primary and secondary causes of mortality.

The total mortality rate of children in this study was 4.1% with a high proportion (31.7%) of early mortality. Pneumonia, congestive heart failure, sepsis, meningitis, late-onset sepsis and hematological diseases were the most common causes of death in children presenting to our emergency department. A delay in presentation of more than 48 h, diarrheal diseases and shortness of breath were significantly associated with early pediatric mortality. Almost all mortality was due to preventable diseases, which can be controlled with minimum resources and quality care provision. We were unable to extract data for a significant proportion of patients due to limitations of and/or missing medical documentation. Efficient, evidence-based triage and intervention by trained ED staff may improve child mortality. Further longitudinal studies on pediatric emergency patients in the African setting are warranted.