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Journal of Endocrinological Investigation

Erschienen in:

01.12.2019 | Original Article

Prevalence of endocrine disorders and their associated factors in transfusion-dependent thalassemia patients: a historical cohort study in Southern Iran

verfasst von: M. Bordbar, H. Bozorgi, F. Saki, S. Haghpanah, M. Karimi, A. Bazrafshan, O. R. Zekavat

Erschienen in: Journal of Endocrinological Investigation | Ausgabe 12/2019

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Abstract

Purpose

Transfusion-dependent beta-thalassemia (TDT) patients suffer from various endocrinopathies. The main contributing factor associated with these complications is iron overload, secondary to frequent blood transfusions. To improve patients’ quality of life, we evaluated the prevalence of endocrine disorders while considering the associated factors for further assessment.

Methods

Seven hundred thirteen transfusion-dependent thalassemia patients with age range 10–62 years were enrolled in this study. Serum calcium, phosphorous, fast blood sugar, ferritin, 25-OH vitamin D, free thyroxin, thyroid-stimulating hormone and parathyroid hormone were assessed. Bone mineral density was measured by dual-energy X-ray absorptiometry.

Results

In total, 86.8% of the TDT patients suffered from at least one endocrinopathy. The prevalence of endocrinopathies in descending order of frequency was low bone mass (72.6%), hypogonadism (44.5%), diabetes mellitus (15.9%), hypoparathyroidism (13.2%), and hypothyroidism (10.7%). Age, body mass index and splenectomy were significantly associated with most of the endocrine disorders.

Conclusion

Endocrine complications are frequently observed in TDT patients. Splenectomy is a major risk factor and should be generally avoided unless it is highly indicated. Periodic surveillance of endocrine function and proper management of iron overload are advised.

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Titel: Prevalence of endocrine disorders and their associated factors in transfusion-dependent thalassemia patients: a historical cohort study in Southern Iran
verfasst von: M. Bordbar
H. Bozorgi
F. Saki
S. Haghpanah
M. Karimi
A. Bazrafshan
O. R. Zekavat
Publikationsdatum: 01.12.2019
Verlag: Springer International Publishing
Erschienen in: Journal of Endocrinological Investigation / Ausgabe 12/2019
Elektronische ISSN: 1720-8386
DOI: https://doi.org/10.1007/s40618-019-01072-z

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Prevalence of endocrine disorders and their associated factors in transfusion-dependent thalassemia patients: a historical cohort study in Southern Iran

Abstract

Purpose

Methods

Results

Conclusion

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