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European Journal of Clinical Microbiology & Infectious Diseases

Erschienen in:

16.10.2020 | Brief Report

Prevalence of genital HPV infection in STI and healthy populations and risk factors for viral persistence

verfasst von: Giulia Ciccarese, Astrid Herzum, Angela Pastorino, Marih Dezzana, Stefania Casazza, Maria Gabriella Mavilia, Francesco Copello, Aurora Parodi, Francesco Drago

Erschienen in: European Journal of Clinical Microbiology & Infectious Diseases | Ausgabe 4/2021

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Abstract

Human papillomavirus (HPV) is a well-established carcinogenic agent. This study aimed to assess prevalence and persistence rate of genital HPV infection in sexually transmitted infections (STIs) patients and healthy subjects. The risk factors influencing the persistence of genital HPV infection were also investigated. The samples were collected with the ThinPrep liquid-based cytology system. Among the HPV-positive patients, those consenting were retested after 12 months. Overall, 145/292 subjects proved HPV positive with a higher prevalence (51%) in STI than in healthy population (43%). The persistence of genital HPV infection was statistically associated with female gender, HR-HPV infection, smoking, and Ureaplasma parvum infection.

Forman D, de Martel C, Lacey CJ et al (2012) Global burden of human papillomavirus and related diseases. Vaccine 30(Suppl 5):F12–F23. https://doi.org/10.1016/j.vaccine.2012.07.055CrossRefPubMed

Moscicki AB, Schiffman M, Burchell A et al (2012) Updating the natural history of human papillomavirus and anogenital cancers. Vaccine 30(Suppl 5):F24–F33. https://doi.org/10.1016/j.vaccine.2012.05.089CrossRefPubMedPubMedCentral

Broccolo F, Ciccarese G, Rossi A et al (2018) Human papillomavirus (HPV) and Epstein-Barr virus (EBV) in keratinizing versus non- keratinizing squamous cell carcinoma of the oropharynx. Infect Agent Cancer 13:32. https://doi.org/10.1186/s13027-018-0205-6CrossRefPubMedPubMedCentral

Ghittoni R, Accardi R, Chiocca S et al (2015) Role of human papillomaviruses in carcinogenesis. Ecancermedicalscience 9:526–535. https://doi.org/10.3332/ecancer.2015.526CrossRefPubMedPubMedCentral

Cossellu G, Fedele L, Badaoui B et al (2018) Prevalence and concordance of oral and genital HPV in women positive for cervical HPV infection and in their sexual stable partners: an Italian screening study. PLoS One 13:e0205574. https://doi.org/10.1371/journal.pone.0205574CrossRefPubMedPubMedCentral

Moscicki AB, Shiboski S, Hills NK et al (2004) Regression of low-grade squamous intra-epithelial lesions in young women. Lancet 364:1678–1683CrossRef

Drago F, Herzum A, Ciccarese G et al (2016) Ureaplasma parvum as a possible enhancer agent of HPV-induced cervical intraepithelial neoplasia: preliminary results. J Med Virol 88:2023–2024. https://doi.org/10.1002/jmv.24583CrossRefPubMed

Deshmukh AA, Tanner RJ, Luetke MC et al (2017) Prevalence and risk of penile human papillomavirus infection: evidence from the national health and nutrition examination survey 2013-2014. Clin Infect Dis 64:1360–1366. https://doi.org/10.1093/cid/cix159CrossRefPubMed

Steinau M, Hariri S, Gillison ML et al (2014) Prevalence of cervical and oral human papillomavirus infections among US women. J Infect Dis 209:1739–1743. https://doi.org/10.1093/infdis/jit799CrossRefPubMed

10.

Sehnal B, Zikan M, Nipcova M et al (2019) The association among cervical, anal, and oral HPV infections in high-risk and low-risk women. Eur J Obstet Gynecol Reprod Biol X 4:100061. https://doi.org/10.1016/j.eurox.2019.100061CrossRefPubMedPubMedCentral

11.

Ciccarese G, Herzum A, Rebora A et al (2017) Prevalence of genital, oral, and anal HPV infection among STI patients in Italy. J Med Virol 89:1121–1124. https://doi.org/10.1002/jmv.24746CrossRefPubMed

12.

Fu T-CF, Carter JJ, Hughes JP et al (2016) Re-detection versus new acquisition of high-risk human papillomavirus in mid-adult women. Int J Cancer 139:2201–2212. https://doi.org/10.1002/ijc.30283CrossRefPubMedPubMedCentral

13.

Kero K, Rautava J, Syrjänen K et al (2014) Smoking increases oral HPV persistence among men: 7-year follow-up study. Eur J Clin Microbiol Infect Dis 33:123–133CrossRef

14.

Giarrè M, Caldeira S, Malanchi I et al (2001) Induction of pRb degradation by the human papillomavirus type 16 E7 protein is essential to efficiently overcome p16INK4a-imposed G1 cell cycle arrest. J Virol 75:4705–4712CrossRef

15.

Guleria C, Suri V, Kapoor R et al (2019) Human papillomavirus 16 infection alters the toll-like receptors and downstream signaling cascade: a plausible early event in cervical squamous cell carcinoma development. Gynecol Oncol 155:151–160. https://doi.org/10.1016/j.ygyno.2019.07.023CrossRefPubMed

16.

Deacon JM, Evans CD, Yule R et al (2000) Sexual behaviour and smoking as determinants of cervical HPV infection and of CIN3 among those infected: a case-control study nested within the Manchester cohort. Br J Cancer 83:1565–1572CrossRef

17.

Moore TO, Moore AY, Carrasco D et al (2001) Human papillomavirus, smoking, and cancer. J Cutan Med Surg 5:323–328CrossRef

18.

Arokiyaraj S, Seo SS, Kwon M et al (2018) Association of cervical microbial community with persistence, clearance and negativity of human papillomavirus in Korean women: a longitudinal study. Sci Rep 8:15479. https://doi.org/10.1038/s41598-018-33750-yCrossRefPubMedPubMedCentral

19.

Ritu W, Enqi W, Zheng S et al (2019) Evaluation of the associations between cervical microbiota and HPV infection, clearance, and persistence in cytologically normal women. Cancer Prev Res (Phila) 12:43–56. https://doi.org/10.1158/1940-6207.CAPR-18-0233CrossRef

20.

Ho GY, Bierman R, Beardsley L et al (1998) Natural history of cervicovaginal papillomavirus infection in young women. N Engl J Med 338:423–428CrossRef

21.

Oyervides-Muñoz MA, Pérez-Maya AA, Sánchez-Domínguez CN et al (2020) Multiple HPV infections and viral load association in persistent cervical lesions in Mexican women. Viruses 12:380CrossRef

22.

van der Weele P, van Logchem E, Wolffs P et al (2016) Correlation between viral load, multiplicity of infection, and persistence of HPV16 and HPV18 infection in a Dutch cohort of young women. J Clin Virol 83:6–11CrossRef

23.

Quint W, Jenkins D, Molijn A et al (2012) One virus, one lesion--individual components of CIN lesions contain a specific HPV type. J Pathol 227:62–71CrossRef

Titel: Prevalence of genital HPV infection in STI and healthy populations and risk factors for viral persistence
verfasst von: Giulia Ciccarese
Astrid Herzum
Angela Pastorino
Marih Dezzana
Stefania Casazza
Maria Gabriella Mavilia
Francesco Copello
Aurora Parodi
Francesco Drago
Publikationsdatum: 16.10.2020
Verlag: Springer Berlin Heidelberg
Erschienen in: European Journal of Clinical Microbiology & Infectious Diseases / Ausgabe 4/2021
Print ISSN: 0934-9723
Elektronische ISSN: 1435-4373
DOI: https://doi.org/10.1007/s10096-020-04073-6

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