nach oben

Indian Journal of Otolaryngology and Head & Neck Surgery

Erschienen in:

21.08.2018 | Original Article

Prevalence of HPV in Oral Squamous Cell Carcinoma in South West India

verfasst von: Pooja Dalakoti, Balakrishnan Ramaswamy, Ajay M. Bhandarkar, Dipak Ranjan Nayak, Sasidharanpillai Sabeena, Govindakarnavar Arunkumar

Erschienen in: Indian Journal of Otolaryngology and Head & Neck Surgery | Sonderheft 1/2019

Einloggen, um Zugang zu erhalten

Abstract

There are inconsistent reports regarding the role of HPV in the origin and progression of oral squamous cell carcinoma (OSCC). The observed heterogeneity was mainly attributed to the social and cultural habits of the enrolled cases, discrepancies in the nature of samples procured and varying sensitivity of the assays employed for detection of HPV. The objective of this study was to assess the prevalence of HPV in OSCC in South West India. This was a cross sectional study conducted over a period extending from October 2015 to June 2017. This study involved Department of ENT-Head and Neck Surgery and Department of Virology, Manipal Academy of Higher Education. Fifty histologically confirmed oral squamous cell carcinoma patients undergoing wide local excision of the tumour were enrolled for the study. Intraoperatively 4–5 mm of tissue samples were transported in sterile normal saline at 4–80 °C. The primary screening of tissue samples was performed by nested PCR using PGMY09/11 consensus primers and GP5+/6+ consensus primers and TaqMan based real time multiplex PCR for HPV-16, HPV-18, HPV-31 and HPV-45. All samples tested negative for HPV DNA by conventional nested PCR and TaqMan based real-time Multiplex PCR ruling out four common HPV subtypes such as HPV-16, 18, 31, 45. We did not find presence of HPV DNA in the tissues of patients with OSCC from southwest India. However, studies with more geographic representation from other parts of India are required before generalising our findings.

Gupta N, Gupta R, Acharya AK et al (2016) Changing trends in oral cancer—a global scenario. Nepal J Epidemiol 6(4):613–619PubMedPubMedCentral

Warnakulasuriya S (2009) Global epidemiology of oral and oropharyngeal cancer. Oral Oncol 45(4–5):309–316

Vigneswaran N, Williams MD (2014) Epidemiological trends in head and neck cancer and aids in diagnosis. Oral Maxillofac Surg Clin N Am 26(2):123–141

Sikora AG, Toniolo P, DeLacure MD (2004) The changing demographics of head and neck squamous cell carcinoma in the United States. Laryngoscope 114(11):1915–1923PubMed

Young D, Xiao CC, Murphy B et al (2015) Increase in head and neck cancer in younger patients due to human papillomavirus (HPV). Oral Oncol 51(8):727–730PubMed

Majchrzak E, Szybiak B, Wegner A et al (2014) Oral cavity and oropharyngeal squamous cell carcinoma in young adults: a review of the literature. Radiol Oncol 48(1):1–10PubMedPubMedCentral

Mishra A, Mehrotra R (2014) Head and neck cancer: global burden and regional trends in India. Asian Pac J Cancer Prev 15(2):537–550CrossRef

Oral Cancer Incidence (New Cases) by Age, Race, and Gender. National Institute of Dental and Craniofacial Research. Accessed on 1 Sept 2017. https://www.nidcr.nih.gov/DataStatistics/FindDataByTopic/OralCancer/OralCancerIncidence.htm

Brierley JD, Gospodarowicz MK, Wittekind C (eds) (2017) Head and neck tumours. In: TNM classification of malignant tumours, 8th edn. Wiley, New York, pp 19–21

10.

Gravitt PE, Peyton CL, Alessi TQ et al (2000) Improved amplification of genital human papillomaviruses. J Clin Microbiol 38(1):357–361PubMedPubMedCentral

11.

de Roda Husman AM, Walboomers JM, van den Brule AJ et al (1995) The use of general primers GP5 and GP6 elongated at their 3’ ends with adjacent highly conserved sequences improves human papillomavirus detection by PCR. J Gen Virol 76(4):1057–1062PubMed

12.

Schmitz M, Scheungraber C, Herrmann J et al (2009) Quantitative multiplex PCR assay for the detection of the seven clinically most relevant high-risk HPV types. J Clin Virol 44(4):302–307PubMed

13.

Nola-Fuchs P, Boras VV, Plecko V et al (2012) The prevalence of human papillomavirus 16 and Epstein-Barr virus in patients with oral squamous cell carcinoma. Acta Clinica Croatica 51(4):609–614PubMed

14.

Winder DM, Ball SL, Vaughan K et al (2009) Sensitive HPV detection in oropharyngeal cancers. BMC Cancer 9(1):440PubMedPubMedCentral

15.

Kabeya M, Furuta R, Kawabata K et al (2012) Prevalence of human papillomavirus in mobile tongue cancer with particular reference to young patients. Cancer Sci 103(2):161–168PubMed

16.

de Spíndula-Filho JV, da Cruz AD, Oton-Leite AF et al (2011) Oral squamous cell carcinoma versus oral verrucous carcinoma: an approach to cellular proliferation and negative relation to human papillomavirus (HPV). Tumour Biol 32(2):409–416PubMed

17.

Fischer M, von Winterfeld F (2003) Evaluation and application of a broad-spectrum polymerase chain reaction assay for human papillomaviruses in the screening of squamous cell tumours of the head and neck. Acta Otolaryngol 123(6):752–758PubMed

18.

Koyama K, Uobe K, Tanaka A (2007) Highly sensitive detection of HPV-DNA in paraffin sections of human oral carcinomas. J Oral Pathol Med 36(1):18–24PubMed

19.

Uobe K, Masuno K, Fang YR, Li LJ, Wen YM, Ueda Y et al (2001) Detection of HPV in Japanese and Chinese oral carcinomas by in situ PCR. Oral Oncol 37(2):146–152PubMed

20.

Laprise C, Madathil SA, Allison P, Abraham P, Raghavendran A, Shahul HP, ThekkePurakkal AS, Castonguay G, Coutlée F, Schlecht NF, Rousseau MC (2016) No role for human papillomavirus infection in oral cancers in a region in southern I ndia. Int J Cancer 138(4):912–917PubMed

21.

Coutlée F, Gravitt P, Kornegay J et al (2002) Use of PGMY primers in L1 consensus PCR improves detection of human papillomavirus DNA in genital samples. J Clin Microbiol 40(3):902–907PubMedPubMedCentral

22.

IARC Monographs—Monographs available in PDF format [Internet]. [cited Dec 8 2017]. http://monographs.iarc.fr/ENG/Monographs/vol100B/index.php

23.

Blot WJ, McLaughlin JK, Winn DM et al (1988) Smoking and drinking in relation to oral and pharyngeal cancer. Can Res 48(11):3282–3287

24.

Chocolatewala NM, Chaturvedi P (2009) Role of human papilloma virus in the oral carcinogenesis: an Indian perspective. J Cancer Res Ther 5(2):71–77PubMed

25.

Gillison ML (2007) Current topics in the epidemiology of oral cavity and oropharyngeal cancers. Head Neck 29(8):779–792PubMed

26.

Kawakami H, Okamoto I, Terao K et al (2013) Human papillomavirus DNA and p16 expression in Japanese patients with oropharyngeal squamous cell carcinoma. Cancer Med 2(6):933–941PubMedPubMedCentral

27.

D’Costa J, Saranath D, Dedhia P et al (1998) Detection of HPV-16 genome in human oral cancers and potentially malignant lesions from India. Oral Oncol 34(5):413–420PubMed

28.

Balaram P, Nalinakumari KR, Abraham E et al (1995) Human papillomaviruses in 91 oral cancers from Indian betel quid chewers–high prevalence and multiplicity of infections. Int J Cancer 61(4):450–454PubMed

29.

Kulkarni SS, Kulkarni SS, Vastrad PP et al (2011) Prevalence and distribution of high risk human papillomavirus (HPV) Types 16 and 18 in Carcinoma of cervix, saliva of patients with oral squamous cell carcinoma and in the general population in Karnataka, India. Asian Pac J Cancer Prev 12(3):645–648PubMed

30.

Paz IB, Cook N, Odom-Maryon T et al (1997) Human papillomavirus (HPV) in head and neck cancer. An association of HPV 16 with squamous cell carcinoma of Waldeyer’s tonsillar ring. Cancer 79(3):595–604PubMed

31.

Watts SL, Brewer EE, Fry TL (1991) Human papillomavirus DNA types in squamous cell carcinomas of the head and neck. Oral Surg Oral Med Oral Pathol 71(6):701–707PubMed

32.

Chaturvedi AK, Engels EA, Anderson WF et al (2008) Incidence trends for human papillomavirus–related and–unrelated oral squamous cell carcinomas in the United States. J Clin Oncol 26(4):612–619PubMed

33.

Lee LA, Huang CG, Liao CT, Lee LY, Hsueh C, Chen TC et al (2012) Human papillomavirus-16 infection in advanced oral cavity cancer patients is related to an increased risk of distant metastases and poor survival. PLoS ONE 7(7):e40767PubMedPubMedCentral

34.

Lang Kuhs KA, Gonzalez P, Struijk L, Castro F, Hildesheim A, van Doorn LJ et al (2013) Prevalence of and risk factors for oral human papillomavirus among young women in Costa Rica. J Infect Dis 208(10):1643–1652PubMedPubMedCentral

35.

Quintero K, Giraldo GA, Uribe ML et al (2013) Human papillomavirus types in cases of squamous cell carcinoma of head and neck in Colombia. Braz J Otorhinolaryngol 79(3):375–381PubMed

36.

Babiker AY, Eltom FM, Abdalaziz MS et al (2013) Screening for high risk human papilloma virus (HR-HPV) subtypes, among Sudanese patients with oral lesions. Int J Clin Exp Med 6(4):275–281PubMedPubMedCentral

37.

Akhter M, Ali L, Hassan Z et al (2013) Association of human papilloma virus infection and oral squamous cell carcinoma in Bangladesh. J Health Popul Nutr 31(1):65–69PubMedPubMedCentral

38.

Ndiaye C, Alemany L, Diop Y et al (2013) The role of human papillomavirus in head and neck cancer in Senegal. Infect Agents Cancer 8(1):14PubMedPubMedCentral

39.

González-Ramírez I, Irigoyen-Camacho ME, Ramírez-Amador V et al (2013) Association between age and high-risk human papilloma virus in Mexican oral cancer patients. Oral Dis 19(8):796–804PubMed

40.

Tezal M, Scannapieco FA, Wactawski-Wende J et al (2012) Local inflammation and human papillomavirus status of head and neck cancers. Arch Otolaryngol Head Neck Surg 138(7):669–675PubMedPubMedCentral

41.

Smith EM, Rubenstein LM, Haugen TH et al (2012) Complex etiology underlies risk and survival in head and neck cancer human papillomavirus, tobacco, and alcohol: a case for multifactor disease. J Oncol 2012:571–862

42.

Kabeya M, Furuta R, Kawabata K et al (2012) Prevalence of human papillomavirus in mobile tongue cancer with particular reference to young patients. Cancer Sci 103(2):161–168PubMed

43.

Lopes V, Murray P, Williams H et al (2011) Squamous cell carcinoma of the oral cavity rarely harbours oncogenic human papillomavirus. Oral Oncol 47(8):698–701PubMed

44.

Saini R, Tang TH, Zain RB et al (2011) Significant association of high-risk human papillomavirus (HPV) but not of p53 polymorphisms with oral squamous cell carcinomas in Malaysia. J Cancer Res Clin Oncol 137(2):311–320PubMed

45.

Machado J, Reis PP, Zhang T et al (2010) Low prevalence of human papillomavirus in oral cavity carcinomas. Head Neck Oncol 2(1):6PubMedPubMedCentral

46.

Siribang P, Buajeeb W, Sanguansin S et al (2008) Detection of human papillomavirus in oral squamous cell carcinoma, leukoplakia and lichen planus in Thai patients. Asian Pac J Cancer Prev 9:771–775

47.

Simonato LE, Garcia JF, Sundefeld ML et al (2008) Detection of HPV in mouth floor squamous cell carcinoma and its correlation with clinicopathologic variables, risk factors and survival. J Oral Pathol Med 37(10):593–598PubMed

48.

Liang XH, Lewis J, Foote R et al (2008) Prevalence and significance of human papillomavirus in oral tongue cancer: the Mayo Clinic experience. J Oral Maxillofac Surg 66(9):1875–1880PubMed

49.

Shimizu M, Adachi A, Zheng S et al (2004) Detection of various types of human papillomavirus DNA, mainly belonging to the cutaneous-group, more frequently in normal tissue than in squamous cell carcinomas of the lip. J Dermatol Sci 36(1):33–39PubMed

50.

Boy S, Rensburg EJ, Engelbrecht S et al (2006) HPV detection in primary intra-oral squamous cell carcinomas–commensal, aetiological agent or contamination? J Oral Pathol Med 35(2):86–90PubMed

51.

Dahlgren L, Dahlstrand HM, Lindquist D et al (2004) Human papillomavirus is more common in base of tongue than in mobile tongue cancer and is a favourable prognostic factor in base of tongue cancer patients. Int J Cancer 112(6):1015–1019PubMed

52.

Ibrahim SO, Bertelsen B, Kalvenes MB et al (1998) Expression of keratin 13, 14 and 19 in oral squamous cell carcinomas from Sudanese snuff dippers: lack of association with human papillomavirus infection. APMIS 106(7–12):959–969PubMed

53.

Kansky AA, Poljak M, Seme K et al (2003) Human papillomavirus DNA in oral squamous cell carcinomas and normal oral mucosa. Acta Virol 47(1):11–16PubMed

54.

Shin KH, Park KH, Hong HJ et al (2002) Prevalence of microsatellite instability, inactivation of mismatch repair genes, p53 mutation, and human papillomavirus infection in Korean oral cancer patients. Int J Oncol 21(2):297–302PubMed

55.

Elango KJ, Suresh A, Erode EM et al (2011) Role of human papilloma virus in oral tongue squamous cell carcinoma. Asian Pac J Cancer Prev 12(4):889–896PubMed

56.

Jalouli J, Ibrahim SO, Mehrotra R et al (2010) Prevalence of viral (HPV, EBV, HSV) infections in oral submucous fibrosis and oral cancer from India. Acta Otolaryngol 130(11):1306–1311PubMed

57.

Gheit T, Vaccarella S, Schmitt M et al (2009) Prevalence of human papillomavirus types in cervical and oral cancers in central India. Vaccine 27(5):636–639PubMed

58.

Koppikar P, deVilliers EM, Mulherkar R (2005) Identification of human papillomaviruses in tumors of the oral cavity in an Indian community. Int J Cancer 113(6):946–950PubMed

59.

Katiyar S, Thelma BK, Murthy NS et al (2003) Polymorphism of the p53 codon 72 Arg/Pro and the risk of HPV type 16/18-associated cervical and oral cancer in India. Mol Cell Biochem 252(1):117–124PubMed

60.

Nagpal JK, Patnaik S, Das BR (2002) Prevalence of high-risk human papilloma virus types and its association with P53 codon 72 polymorphism in tobacco addicted oral squamous cell carcinoma (OSCC) patients of Eastern India. Int J Cancer 97(5):649–653PubMed

61.

Khanna R, Rao GR, Tiwary SK et al (2009) Detection of human papilloma virus 16 and 18 DNA sequences by southern blot hybridization in oral leukoplakia and squamous cell carcinoma. Indian J Surg 71(2):69–72PubMedPubMedCentral

Titel: Prevalence of HPV in Oral Squamous Cell Carcinoma in South West India
verfasst von: Pooja Dalakoti
Balakrishnan Ramaswamy
Ajay M. Bhandarkar
Dipak Ranjan Nayak
Sasidharanpillai Sabeena
Govindakarnavar Arunkumar
Publikationsdatum: 21.08.2018
Verlag: Springer India
Erschienen in: Indian Journal of Otolaryngology and Head & Neck Surgery / Ausgabe Sonderheft 1/2019
Print ISSN: 2231-3796
Elektronische ISSN: 0973-7707
DOI: https://doi.org/10.1007/s12070-018-1470-9

Neu im Fachgebiet HNO

16.04.2024 | HNO-Chirurgie | Nachrichten

Update HNO

Bestellen Sie unseren Fach-Newsletter und bleiben Sie gut informiert – ganz bequem per eMail.

Newsletter bestellen

Springer Medizin

Prevalence of HPV in Oral Squamous Cell Carcinoma in South West India

Abstract

Neu im Fachgebiet HNO

HNO-Op. auch mit über 90?

Intrakapsuläre Tonsillektomie gewinnt an Boden

Bilateraler Hörsturz hat eine schlechte Prognose

„Nur wer sich gut aufgehoben fühlt, kann auch für Patientensicherheit sorgen“

Update HNO

Springer Medizin

Abstract

Bitte loggen Sie sich ein, um Zugang zu diesem Inhalt zu erhalten

Weitere Artikel der Sonderheft 1/2019

Role of Toluidine Blue Staining in Suspicious Lesions of Oral Cavity and Oropharynx

Tolerance of Chemoradiation in Advanced Head and Neck Cancers: Comparison Between Inpatients and Outpatients

Von Recklinghausen’s Disease Presenting as Otolaryngologic Emergency: A Rare Occurrence

Occult Primary with Cervical Secondary-Role of CT Scan and Evaluation Under Anesthesia

Biomarkers in Head and Neck Cancer an Update

Adenoid Cystic Carcinoma of the Nasopharynx: A Case Series

Neu im Fachgebiet HNO

HNO-Op. auch mit über 90?

Intrakapsuläre Tonsillektomie gewinnt an Boden

Bilateraler Hörsturz hat eine schlechte Prognose

„Nur wer sich gut aufgehoben fühlt, kann auch für Patientensicherheit sorgen“

Update HNO