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Clinical and Experimental Nephrology
Erschienen in: Clinical and Experimental Nephrology 1/2008

01.02.2008 | Original Article

Prevention of DNA damage in renal transplantation by losartan and enalapril: the role of renin-angiotensin system polymorphisms

verfasst von: Amir Ghorbanihaghjo, Pegah Veisi, Hassan Argani, Mohammad Aghaeishahsavari, Masood Noroozianavval, Nadereh Rashtchizadeh, Mehran Mesgari, Javid Safa, Hosain Babaei

Erschienen in: Clinical and Experimental Nephrology | Ausgabe 1/2008

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Abstract

Background

In this study the effect of losartan and enalapril on the reduction of DNA damage was evaluated in regard to renin-angiotensin system (RAS) polymorphisms.

Methods

After determination of genotypes of RAS polymorphism by PCR, 64 renal transplant recipients were randomly allocated to one of four groups: the first and second groups were treated with E (E+: 10 mg/day) and L (L+: 50 mg/day) alone, respectively. The third group received E+L (E+L+: 10 + 50 mg/day), and the forth group received no medication (E−L−). The subjects were followed for 8 weeks. After a 2-week washout period, the E group changed to L and vice versa as a cross-over design. They were followed for another 8 weeks. Before and after treatment, we checked 8-OHdG and malondialdehyde (MDA) as biomarkers of DNA damage and lipid peroxidation, respectively.

Results

8-OHdG levels were significantly decreased after treatment in the E+L+ and L+ groups (P < 0.001, P = 0.001, respectively). Only the TT genotype of AGT had the most antioxidative role regarding the treatment (P = 0.01). We found a remarkable correlation between MDA and DNA damage levels before and after intervention (r = 0.48, P < 0.001; r = 0.35, P = 0.006).

Conclusion

The protective effects of L+ and E+L+ on DNA breaks are surprising regarding the RAS polymorphisms.
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Metadaten
Titel
Prevention of DNA damage in renal transplantation by losartan and enalapril: the role of renin-angiotensin system polymorphisms
verfasst von
Amir Ghorbanihaghjo
Pegah Veisi
Hassan Argani
Mohammad Aghaeishahsavari
Masood Noroozianavval
Nadereh Rashtchizadeh
Mehran Mesgari
Javid Safa
Hosain Babaei
Publikationsdatum
01.02.2008
Verlag
Springer Japan
Erschienen in
Clinical and Experimental Nephrology / Ausgabe 1/2008
Print ISSN: 1342-1751
Elektronische ISSN: 1437-7799
DOI
https://doi.org/10.1007/s10157-007-0001-x

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