Erschienen in:
01.11.2015 | Invited Commentary
Probiotics in Colorectal Surgery
verfasst von:
Robert Martindale, Malissa Warren, Vassiliki L. Tsikitis
Erschienen in:
World Journal of Surgery
|
Ausgabe 11/2015
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Excerpt
We read, with great interest, the manuscript published by Dr. Kotzampassi et al. from the Department of Surgery at Aristotle University at the Thessaloniki Medical School in Greece in the April 2015 edition of the World Journal of Surgery [
1]. In a prospective randomized trial, the authors evaluated the use of a combination of three probiotic strains and a fungus commonly referred to as a probiotic in colorectal cancer patients requiring an open resection with primary anastomosis. Although the current study reports a significantly higher than average morbidity for colon surgery, their findings include a significant decrease in postoperative major morbidity in the probiotic group. The authors do not clarify the type of mechanical bowel preparation that was used, and they include all patients with colorectal cancer who did not receive neoadjuvant treatment. The complications that decreased included surgical site infection, pneumonia, and anastomotic leak. The study power analysis was originally planned for 208 patients, but, at the interim analysis, significance difference was noted between the groups, and the study accrual was stopped at 164 patients. …
