nach oben

Experimental Brain Research

Erschienen in:

01.04.2005 | Research Article

Processing of a simple aversive conditioned stimulus in a divided visual field paradigm: an fMRI study

verfasst von: Silke Anders, Martin Lotze, Dirk Wildgruber, Michael Erb, Wolfgang Grodd, Niels Birbaumer

Erschienen in: Experimental Brain Research | Ausgabe 2/2005

Einloggen, um Zugang zu erhalten

Abstract

A left visual hemifield advantage for the processing of negative facial expressions has been demonstrated in a variety of studies. We tested whether the same effect is found for a neutral facial expression that had acquired a negative meaning through pairing with an aversive event. Startle reflex amplitudes, skin-conductance responses (SCR), and two verbal measures of affect (negative valence and arousal) were significantly increased after pairing, but no stimulation side by pairing interaction was observed. Functional magnetic resonance imaging (fMRI) revealed a significant increase of BOLD (blood oxygen level dependent) activity in the medial prefrontal cortex (MPFC), and the right frontal opercular region (RFOP). MPFC activity was correlated with psychophysiological and verbal emotional responses across subjects and, like these responses, was independent of the stimulation side. In contrast, RFOP activity was significantly stronger during left than during right hemifield stimulation but did not correlate with psychophysiological or verbal measures of negative affect. These results suggest that emotional responses to an aversive conditioned expressively neutral face are similar in both visual hemifields. MPFC activity seems to be closely linked to the strength of these responses.

Adolphs R (2002) Neural systems for recognizing emotion. Curr Opin Neurobiol 12:169–177CrossRefPubMed

Anders S, Birbaumer N, Sadowski B, Erb M, Mader I, Grodd W, Lotze M (2004a) Parietal somatosensory association cortex mediates affective blindsight. Nat Neurosci 7:339–340CrossRefPubMed

Anders S, Weiskopf N, Lule D, Birbaumer N (2004b) Infrared oculography—validation of a new method to measure startle eyeblink amplitudes during fMRI Neuroimage DOI 10.1016/j.neuroimage.2004.01.024)

Baumgart F, Kaulisch T, Tempelmann C, Gaschler-Markefski B, Tegeler C, Schindler F, Stiller D, Scheich H (1998) Electrodynamic headphones and woofers for application in magnetic resonance imaging scanners. Med Phys 25:2068–2070CrossRefPubMed

Bechara A, Damasio H, Damasio AR, Lee GP (1999) Different contributions of the human amygdala and ventromedial prefrontal cortex to decision-making. J Neurosci 19:5473–5481

Blair RJ, Morris JS, Frith CD, Perrett DI, Dolan RJ (1999) Dissociable neural responses to facial expressions of sadness and anger. Brain 122:883–893CrossRefPubMed

Bradley MM, Lang PJ (1994) Measuring emotion: the self-assessment manikin and the semantic differential. J Behav Ther Exp Psychiatr 25:49–59CrossRefPubMed

Brown HD, Kosslyn SM (1993) Cerebral lateralization. Curr Opin Neurobiol 3:183–186CrossRefPubMed

Borod JC, Bloom RL, Zgaljardic D, Tabert MH, Koff E (2002) Asymmetries of emotional perception and expression in normal adults. In: Gainotti G (ed) Handbook of neuropsychology, 2nd edn. Elsevier, pp 181–205

Büchel C, Dolan RJ, Armony JL, Friston KJ (1999) Amygdala-hippocampal involvement in human aversive trace conditioning revealed through event-related functional magnetic resonance imaging. J Neurosci 15: 10869–10876

Canli T, Desmond JE, Zhao Z, Glover G, Gabrieli JD (1998) Hemispheric asymmetry for emotional stimuli detected with fMRI. Neuroreport 9:3233–3239PubMed

Collins DL, Neelin P, Peters TM, Evans AC (1994) Automatic 3D intersubject registration of MR volumetric data in standardized Talairach space. J Comput Assist Tomo 18:192–205

Davidson RJ (1992) Anterior cerebral asymmetry and the nature of emotion. Brain Cognit 20:125–151CrossRef

Dolan RJ, Fletcher P, Morris J, Kapur N, Deakin JF, Frith CD (1996) Neural activation during covert processing of positive emotional facial expressions. Neuroimage 4:194–200CrossRefPubMed

George MS, Ketter TA, Gill DS, Haxby JV, Ungerleider LG, Herscovitch P, Post RM (1993) Brain regions involved in recognizing facial emotion or identity: an oxygen-15 PET study. J Neuropsychiatr Clin Neurosci 5:384–394

Glascher J, Adolphs R (2003) Processing of the arousal of subliminal and supraliminal emotional stimuli by the human amygdala. J Neurosci 23:10274–10282PubMed

Gusnard DA, Akbudak E, Shulman GL, Raichle ME (2001) Medial prefrontal cortex and self-referential mental activity: relation to a default mode of brain function. Proc Natl Acad Sci USA 98:4259–4264CrossRefPubMed

Hugdahl K, Johnsen BH (1991) Brain asymmetry and human electrodermal conditioning. Integr Physiol Behav Sci 26:39–44PubMed

Hugdahl K, Berardi A, Thompson WL, Kosslyn SM, Macy R, Baker DP, Alpert NM, LeDoux JE (1995) Brain mechanisms in human classical conditioning: a PET blood flow study. Neuroreport 11:1723–1728

Iidaka T, Omori M, Murata T, Kosaka H, Yonekura Y, Okada T, Sadato N (2001) Neural interaction of the amygdala with the prefrontal and temporal cortices in the processing of facial expressions as revealed by fMRI. J Cognit Neurosci 13:1035–1047CrossRef

Johnsen BH, Hugdahl K (1993) Right hemisphere representation of autonomic conditioning to facial emotional expressions. Psychophysiology 30:274–278PubMed

Johnsen BH, Hugdahl K (1994) Brain asymmetry and autonomic conditioning: sensitization control. Integr Physiol Behav Sci 29:395–405PubMed

Kesler-West ML, Andersen AH, Smith CD, Avison MJ, Davis CE, Kryscio RJ, Blonder LX (2001) Neural substrates of facial emotion processing using fMRI. Cognit Brain Res 11:213–226CrossRef

Kimmig H, Greenlee MW, Huethe F, Mergner T (1999) MR-eyetracker: a new method for eye movement recording in functional magnetic resonance imaging. Exp Brain Res 126:443–449CrossRefPubMed

LeDoux J (1996) The Emotional Brain. Simon and Schuster, New York, 384 pp

Lane RD, Fink GR, Chau PML, Dolan RJ (1997) Neural activation during selective attention to subjective emotional responses. Neuroreport 8:3969–3972PubMed

Levy J, Heller W, Banich MT, Burton LA (1983) Asymmetry of perception in free viewing of chimeric faces. Brain Cognit 2:404–419CrossRef

Morris JS, Friston KF, Büchel C, Frith CD, Young AW, Calder AJ, Dolan RJ (1998) A neuromodulatory role for the human amygdala in processing emotional facial expressions. Brain 121:47–57CrossRefPubMed

Nakamura K, Kawashima R, Ito K, Sugiura M, Kato T, Nakamura A, Hatano K, Nagumo S, Kubota K, Fukuda H, Kojima S (1999) Activation of the right inferior frontal cortex during assessment of facial emotion. Neuropsychologia 82:1610–1614

Narumoto J, Yamada H, Iidaka T, Sadato N, Fukui K, Itoh H, Yonekura Y (2000) Brain regions involved in verbal or non-verbal aspects of facial emotion recognition. Neuroreport 11:2571–2576PubMed

Olkin J (1967) Correlations revisited. In: Stanley JC (ed) Improving experimental design and statistical analysis. Rand McNalley, Chicago

Ongur D, Price JL (2000) The organization of networks within the orbital and medial prefrontal cortex of rats, monkeys and humans. Cerebral Cortex 10:206–219CrossRefPubMed

O’Scalaidhe SP, Wilson FA, Goldman-Rakic PS (1997) Areal segregation of face-processing neurons in prefrontal cortex. Science 278:1135–1138CrossRefPubMed

Phan KL, Wager T, Taylor SF, Liberzon I (2002) Functional neuroanatomy of emotion: a meta-analysis of emotion activation studies in PET and fMRI. Neuroimage 16:331–348CrossRefPubMed

Price CJ, Friston KJ (1997) Cognitive conjunction: a new approach to brain activation experiments. Neuroimage 5:261–270CrossRefPubMed

Schupp HT, Junghofer M, Weike AI, Hamm AO (2003) Emotional facilitation of sensory processing in the visual cortex. Psychol Sci 14:7–13CrossRefPubMed

Semmes J (1968) Hemispheric spezialisation: A possible clue to mechanism. Neuropsychologia 6:11–26

Sereno MI, Dale AM, Reppas JB, Kwong KK, Belliveau JW, Brady TJ, Rosen BR, Tootell RBH (1995) Borders of multiple visual areas in humans revealed by functional magnetic resonance imaging. Science 268:889–893PubMed

Sprengelmeyer R, Rausch M, Eysel UT, Przuntek H (1998) Neural structures associated with recognition of facial expressions of basic emotions. Proc R Soc, London, Biol Sci 265:1927–1931

Tzourio-Mazoyer N, Landeau B, Papathanassiou D, Crivello F, Etard O, Delcroix N, Mazoyer B, Joliot M (2002) Automated anatomical labeling of activations in SPM using a macroscopic anatomical parcellation of the MNI MRI single-subject brain. Neuroimage 15:273–289CrossRefPubMed

Worsley KJ, Marrett S, Neelin P, Vandal AC, Friston KJ, Evans AC (1995) A unified statistical approach for determining significant signals in images of cerebral activation. Human Brain Mapping 4:58–73

Titel: Processing of a simple aversive conditioned stimulus in a divided visual field paradigm: an fMRI study
verfasst von: Silke Anders
Martin Lotze
Dirk Wildgruber
Michael Erb
Wolfgang Grodd
Niels Birbaumer
Publikationsdatum: 01.04.2005
Verlag: Springer-Verlag
Erschienen in: Experimental Brain Research / Ausgabe 2/2005
Print ISSN: 0014-4819
Elektronische ISSN: 1432-1106
DOI: https://doi.org/10.1007/s00221-004-2145-1

Leitlinien kompakt für die Neurologie

Mit medbee Pocketcards sicher entscheiden.

^{Seit 2022 gehört die medbee GmbH zum Springer Medizin Verlag}

Kostenlos registrieren

Neu im Fachgebiet Neurologie

Thrombektomie auch bei großen Infarkten von Vorteil

16.05.2024 Ischämischer Schlaganfall Nachrichten

Auch ein sehr ausgedehnter ischämischer Schlaganfall scheint an sich kein Grund zu sein, von einer mechanischen Thrombektomie abzusehen. Dafür spricht die LASTE-Studie, an der Patienten und Patientinnen mit einem ASPECTS von maximal 5 beteiligt waren.

Schwindelursache: Massagepistole lässt Otholiten tanzen

14.05.2024 Benigner Lagerungsschwindel Nachrichten

Wenn jüngere Menschen über ständig rezidivierenden Lagerungsschwindel klagen, könnte eine Massagepistole der Auslöser sein. In JAMA Otolaryngology warnt ein Team vor der Anwendung hochpotenter Geräte im Bereich des Nackens.

Schützt Olivenöl vor dem Tod durch Demenz?

10.05.2024 Morbus Alzheimer Nachrichten

Konsumieren Menschen täglich 7 Gramm Olivenöl, ist ihr Risiko, an einer Demenz zu sterben, um mehr als ein Viertel reduziert – und dies weitgehend unabhängig von ihrer sonstigen Ernährung. Dafür sprechen Auswertungen zweier großer US-Studien.

Bluttest erkennt Parkinson schon zehn Jahre vor der Diagnose

10.05.2024 Parkinson-Krankheit Nachrichten

Ein Bluttest kann abnorm aggregiertes Alpha-Synuclein bei einigen Menschen schon zehn Jahre vor Beginn der motorischen Parkinsonsymptome nachweisen. Mit einem solchen Test lassen sich möglicherweise Prodromalstadien erfassen und die Betroffenen früher behandeln.

Update Neurologie

Bestellen Sie unseren Fach-Newsletter und bleiben Sie gut informiert.

Newsletter bestellen

Springer Medizin

Abstract

Bitte loggen Sie sich ein, um Zugang zu diesem Inhalt zu erhalten

Weitere Artikel der Ausgabe 2/2005

Feeling what you hear: auditory signals can modulate tactile tap perception

Extensor spasms triggered by imposed knee extension in chronic human spinal cord injury

The detection of multisensory stimuli in an orthogonal sensory space

Development of visuomotor representations for hand movement in young children

Course of spinocerebellar axons in the ventral and lateral funiculi of the spinal cord with projections to the posterior cerebellar termination area: an experimental anatomical study in the cat, using a retrograde tracing technique

Velocity and curvature in human locomotion along complex curved paths: a comparison with hand movements