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27.02.2018 | Hepatobiliary-Pancreas

Prognostic Role of Liver Stiffness Measurements Using Magnetic Resonance Elastography in Patients with Compensated Chronic Liver Disease

verfasst von: Dong Ho Lee, Jeong Min Lee, Won Chang, Jung-Hwan Yoon, Yoon Jun Kim, Jeong-Hoon Lee, Su Jong Yu, Joon Koo Han

Erschienen in: European Radiology | Ausgabe 8/2018

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Abstract

Purpose

To retrospectively evaluate the prognostic role of liver stiffness (LS) measurement using magnetic resonance elastography (MRE) in patients with compensated chronic liver disease (cCLD).

Methods

We enrolled 217 patients with cCLD who underwent MRE. After mean follow-up of 45.0 ± 17.6 months, cumulative incidence (CI) of hepatocellular carcinoma (HCC) occurrence, development of decompensation and overall survival (OS) were estimated using the Kaplan-Meier method. Prognostic factors were evaluated using the Cox proportional hazard regression model.

Results

During the follow-up period, HCC occurred in 33 patients, and 1-, 3- and 5-year CIs of HCC occurrence were 3.8%, 14.8% and 18.9%, respectively. The LS value was a significant predictive factor for HCC occurrence [p < 0.001, hazard ratio (HR) = 1.59 per unit (1.25-2.03)]. Eighteen patients experienced hepatic decompensation, and 1-, 3- and 5-year CIs of decompensation were 2.8%, 7.3% and 11.3%, respectively. The LS value was also significantly associated with decompensation development [p < 0.001, HR = 2.02 per unit (1.37-2.98)]. Fourteen patients died, and 1-, 3- and 5-year OSs were 99.1%, 98.0% and 89.8%, respectively. The LS value was demonstrated to be a significant affecting factor for OS [p = 0.008, HR = 1.39 per unit (1.10-1.78)].

Conclusions

LS obtained from MRE was a significant predictive factor for the development of decompensation, HCC occurrence and OS in cCLD patients.

Key Points

• Liver stiffness (LS) values obtained from MRE can provide prognostic information.

• The LS value was a significant predictive factor for occurrence of hepatocellular carcinoma.

• The LS value was significantly associated with development of hepatic decompensation.

• Survival of compensated chronic liver disease patients was affected by the LS value.

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Titel: Prognostic Role of Liver Stiffness Measurements Using Magnetic Resonance Elastography in Patients with Compensated Chronic Liver Disease
verfasst von: Dong Ho Lee
Jeong Min Lee
Won Chang
Jung-Hwan Yoon
Yoon Jun Kim
Jeong-Hoon Lee
Su Jong Yu
Joon Koo Han
Publikationsdatum: 27.02.2018
Verlag: Springer Berlin Heidelberg
Erschienen in: European Radiology / Ausgabe 8/2018
Print ISSN: 0938-7994
Elektronische ISSN: 1432-1084
DOI: https://doi.org/10.1007/s00330-017-5278-x

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Prognostic Role of Liver Stiffness Measurements Using Magnetic Resonance Elastography in Patients with Compensated Chronic Liver Disease