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01.12.2014 | Research | Ausgabe 1/2014 Open Access

World Journal of Surgical Oncology 1/2014

Prognostic role of microRNA-145 in various human malignant neoplasms: a meta-analysis of 18 related studies

Zeitschrift:
World Journal of Surgical Oncology > Ausgabe 1/2014
Autoren:
Jie Yang, Jia-yi Zhang, Jing Chen, Chen Chen, Xiao-meng Song, Yang Xu, Jie Li
Wichtige Hinweise

Electronic supplementary material

The online version of this article (doi:10.​1186/​1477-7819-12-254) contains supplementary material, which is available to authorized users.
Jie Yang, Jia-yi Zhang, Jing Chen contributed equally to this work.

Competing interests

The authors declare that they have no conflict of interests.

Authors’ contributions

JY and JL conceived and designed the study; JC and CC collected the data; YX and XS checked and verified the data input by JC and CC; JZ and JC performed statistical analyses; JY and JZ drafted the manuscript; and JY and JL revised the manuscript. All authors have read and approved the final version.

Abstract

Background

Recent studies show that microRNA-145 (miR-145) might be an attractive tumor biomarker of considerable prognostic value. To clarify the preliminary predictive value of miR-145 for prognosis in various malignant neoplasms, we conducted a meta-analysis of 18 relevant studies.

Methods

Eligible studies were identified by searching the online databases PubMed, EMBASE, and Web of Science up to March 2014. Pooled hazard ratios (HRs) with 95% confidence intervals (CIs) for patient survival and disease progress were calculated to investigate the association with miR-145 expression.

Results

In total, 18 eligible studies were included in this meta-analysis. Our results showed that upregulated miR-145 significantly predicted a favorable overall survival (OS) (HR = 0.47, 95% CI 0.31 to 0.72), but failed to show a significant relation with disease prognosis. In stratified analyses, high miR-145 expression predicted favorable OS in both Whites and Asians but the intensity of the association in Whites (HR = 0.67, 95% CI 0.47 to 0.95) was not as strong as in Asians (HR = 0.35, 95% CI 0.19 to 0.64). High miR-145 expression also predicted better progression-free survival (PFS) in Asians (HR = 0.43, 95% CI 0.21 to 0.89), but not in Whites. In addition, a significantly favorable OS associated with upregulated miR-145 expression was observed in both squamous cell (SCC) (HR = 0.34, 95% CI 0.13 to 0.93) and glioblastoma (HR = 0.72, 95% CI 0.52 to 0.99).

Conclusions

Our findings indicate that high miR-145 expression is better at predicting patient survival rather than disease progression for malignant tumors, especially for SCC and glioblastoma in Asians. Considering the insufficient evidence, further investigations and more studies are needed.
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