Introduction
Methods
Literature search strategy
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Studies concerning patients with gastric cancer
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Comparative studies of patients with positive and negative peritoneal cytology
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Comparative studies evaluating the effect of neoadjuvant chemotherapy upon patients with positive cytology from gastric cancer
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Comparative studies of patients with positive peritoneal cytology in the absence of macroscopic peritoneal disease and patients with macroscopic peritoneal disease.
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Studies published in a language other than English
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Case reports or cohort studies including fewer than ten patients
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Noncomparative studies or studies not concerning peritoneal cytology and gastric cancer.
Outcome measures for meta-analysis of comparative studies
Statistical analysis
Results
Patient demographics
Study | Total patients | F:M ratio | Median age | Age range | No. patients | Cyt +ve | Recurrence | No. patients | Cyt −ve | Recurrence |
---|---|---|---|---|---|---|---|---|---|---|
Comorbidities | Comorbidities | |||||||||
Badgwell | 381 | 1/1.8 | 61 | 24–88 | 39 | 223 | ||||
Bentrem | 371 | 1/1.2 | 67 | 21–88 | 24 | 347 | ||||
Brito | 72 | 1/1.8 | 60.4 | 47.1–73.7 | 8 | 64 | ||||
Chuwa | 142 | 1/1.8 | 36 | 17 | 6 | 1C6 | 17 | 6 | ||
Euanoraster | 97 | 1/1.8 | 22 | 22 | 75 | 22 | ||||
Fukagawa | 996 | 1/1.1 | 225 | 541 | ||||||
Jiang | 139 | 57 | 28–80 | 38 | 31 | 101 | 31 | |||
Kang | 75 | 1.2.1 | 7 | 6 | 68 | 6 | ||||
Katsuragi | 124 | 1/2.1 | 26 | 32 | 39 | 32 | ||||
Kodera | 70 | 13 | 22 | |||||||
La Torre | 64 | 01/01/01 | 64.5 | 29–84 | 7 | 57 | ||||
Lee | 1072 | 172 | 900 | |||||||
Makino | 113 | 1/2.1 | 35 | 78 | ||||||
de Manzon | 168 | 1/1.7 | 145 | 23 | ||||||
Miyashiro | 417 | 1/0.6 | 61 | 27–87 | 25 | 295 | ||||
Nakagawa | 100 | 1/0.6 | 62 | 28–83 | 9 | 30 | ||||
Noda | 1474 | 1/1.9 | 91 | 1383 | ||||||
Ribeiro | 201 | 1/2.2 | 15 | 186 | ||||||
Rosenberg | 351 | 1/1.65 | 74 | 272 | ||||||
Wong | 38 | 31 | 125 | |||||||
Total | 6465 | 1042 | 4935 |
Nodal involvement | Primary tumor | (Clinical T disease) | Tumor differentiation | Histological type | Angiolymphatic invasion | |||
---|---|---|---|---|---|---|---|---|
T1–T2 | T3–T4 | Differentiated | Poorly differentiated | Intestinal | Diffuse | |||
(a) Positive cytology | ||||||||
Badgwel | 6 | 30 | ||||||
Bentrem | 150 | 4 | 19 | |||||
Brito | 5 | 0–2(5), 3–4 (37) | 5 | 3 | 5 | |||
Chuwa | 28 | 0 | 36 | |||||
Euanoraster | 22 | 14 | 2 | 20 | 18 | |||
Fukagawa | 234 | 307 | ||||||
Jiang | 29 | 3 | 35 | 14 | 24 | 18 | 20 | 17 |
Kang | 5 | 0 | 7 | 1 | 6 | |||
Katsuragi | 34 | 5 | 41 | 14 | 11 | |||
Kodera | 20 | 2 | 20 | |||||
La Torre | 7 | 1 | 6 | |||||
Lee | 105 | 6 | 102 | 31 | 141 | 37 | 55 | |
Makino | 28 | 35 | 5 | 30 | ||||
de Manzoni | 13 | 0 | 23 | 9 | 14 | |||
Miyashiro | 25 | 10 | 15 | 7 | 18 | |||
Nakagawa | ||||||||
Noda | 88 | 2 | 89 | 33 | 58 | 41 | ||
Riheiro | 14 | 0 | 15 | 6 | 9 | |||
Rosenberg | 57 | 36 | 38 | |||||
Wong | 2 | 0 | 2 | 1 | 1 | 1 | 1 | 4 |
(b) Negative cytology | ||||||||
Badgwel | 45 | 165 | ||||||
Bentrem | 14 | 172 | 48 | |||||
Brito | 42 | 5 | 3 | 36 | 26 | |||
Chuwa | 44 | 46 | 60 | 24 | ||||
Euanoraster | 61 | 14 | 61 | 25 | 50 | |||
Fukagawa | 6 | 13 | 21 | |||||
Jiang | 53 | 40 | 61 | 41 | 60 | 46 | 55 | |
Kang | 46 | 23 | 45 | 25 | 43 | 14 | ||
Katsuragi | 46 | 47 | 23 | 33 | 37 | |||
Kodera | 29 | 6 | 31 | |||||
La Torre | 36 | 39 | 18 | |||||
Lee | 648 | 368 | 429 | 271 | 629 | 359 | 367 | |
Makino | 49 | 78 | 35 | 43 | ||||
de Manzoni | 77 | 78 | 67 | 83 | 62 | |||
Miyashiro | ||||||||
Nakagawa | 559 | |||||||
Noda | 977 | 411 | 972 | 577 | 806 | |||
Ribeiro | 131 | 66 | 120 | 85 | 101 | |||
Rosenberg | 114 | 223 | 49 | |||||
Wong |