Prognostic Value of Combination of Lymphocyte-to-Monocyte-Ratio and CYFRA 21-1 in Esophageal Squamous Cell Carcinoma
- 04.10.2023
- Original Scientific Report
Erschienen in:
- Verfasst von
- Yuxin Yang
- Zhichao Liu
- Chao Jiang
- Jie Pan
- Boyao Yu
- Kaiyuan Zhu
- Yunhua Xu
- Zhigang Li
- Erschienen in
- World Journal of Surgery | Ausgabe 12/2023
Abstract
Background
This study aimed to investigate the potential of a combined score based on CYFRA 21-1 level and LMR as a prognostic predictor for patients with ESCC.
Methods
A total of 460 patients who underwent esophagectomy were analyzed, and three groups were established based on the CA-LMR score. OS and RFS were evaluated using the Kaplan–Meier analysis, and associated factors were analyzed by univariate and multivariate Cox analysis. A mpStage system was also established based on the CA-LMR score.
Results
The allocation of CA-LMR score of 0, 1, and 2 was 107 (23.3%), 280 (60.9%), and 73 (15.9%). There was a significant association between CA-LMR and male gender (P = 0.001), lower BMI (P = 0.035), longer tumor lesions (P = 0.002), and high pT, pN, pStage (P < 0.001, P = 0.011, P = 0.001). The 5-year OS rates for CA-LMR scores of 0, 1, and 2 were 75.4%, 60.2%, and 32.8%, respectively (P < 0.001). Multivariate analysis showed that CA-LMR score (P = 0.011) was an independent prognostic factor for OS. The proposed mpStage system, based on CA-LMR score, demonstrated superior discriminatory ability, monotonicity, homogeneity, and prognosis prediction ability over AJCC 8th pStage system.
Conclusions
The CA-LMR score, combined with tumor marker and inflammatory index, could use as a potential prognostic indicator; moreover, our modified pStage system exhibited superior stratification and prognostic accuracy for patients with ESCC.
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- Titel
- Prognostic Value of Combination of Lymphocyte-to-Monocyte-Ratio and CYFRA 21-1 in Esophageal Squamous Cell Carcinoma
- Verfasst von
-
Yuxin Yang
Zhichao Liu
Chao Jiang
Jie Pan
Boyao Yu
Kaiyuan Zhu
Yunhua Xu
Zhigang Li
- Publikationsdatum
- 04.10.2023
- Verlag
- Springer International Publishing
- Erschienen in
-
World Journal of Surgery / Ausgabe 12/2023
Print ISSN: 0364-2313
Elektronische ISSN: 1432-2323 - DOI
- https://doi.org/10.1007/s00268-023-07190-3
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