Skip to main content
Hauptrubriken
CME Facharzt-Training Webinare Zeitschriften Bücher e.Medpedia Podcast
Service
Jobbörse Info & Hilfe
Fachgebiete
Anästhesiologie Allgemeinmedizin Arbeitsmedizin Augenheilkunde Chirurgie Dermatologie Gynäkologie und Geburtshilfe HNO Innere Medizin Kardiologie Neurologie Onkologie und Hämatologie Orthopädie und Unfallchirurgie Pädiatrie Pathologie Psychiatrie Radiologie Rechtsmedizin Urologie Zahnmedizin
Themen
Klimawandel und Gesundheit Neues aus dem Markt COVID-19 Praxis und Beruf Seltene Erkrankungen GOÄ & EBM Panorama
Sammlungen
Kasuistiken Algorithmen & Infografiken Blickdiagnosen Arthropedia FlapFinder (für Dermatochirurgen) Videos Kongressberichterstattung Medizin für Apothekerinnen und Apotheker Für Ärztinnen und Ärzte in Weiterbildung Für Medizinstudierende
Erweiterte Suche
Anmelden
nach oben
Digestive Diseases and Sciences
Erschienen in: Digestive Diseases and Sciences 5/2007

01.05.2007 | Review Article

Progress of Study on the Relationship Between Mediators of Inflammation and Apoptosis in Acute Pancreatitis

verfasst von: Xi-Ping Zhang, Qian Lin, Yi-Feng Zhou

Erschienen in: Digestive Diseases and Sciences | Ausgabe 5/2007

Einloggen, um Zugang zu erhalten

Abstract

As an important pathological feature of acute pancreatitis, apoptosis may occur in multiple organs and relate directly to the progression of disease. It is mainly controlled by the apoptosis gene and also influenced by inflammatory mediators. We summarize here the roles of the main inflammatory mediators (e.g., NO, TNF-α, TGF-β1, IL-10, NF-κB) during the pathologic process of acute pancreatitis.
Literatur
1.
Norman J (1998) The role of cytokine in the pathogenesis of acute pancreatitis. Am J Surg 175:76–83 [PMID: 9445247]PubMedCrossRef
2.
Wang ZF, Pang CE, Liu SG (1998) Role of inflammatory mediators in acute pancreatitis. Shijie Huaren Xiaohua Zazhi 6:170–171 [in Chinese]
3.
Kaiser AM, Saluja AK, Lu L, Yamanaka K, Yamaguchi Y, Steer ML (1996) Effects of cycloheximide on pancreatic endonuclease activity, apoptosis, and severity of acute pancreatitis. Am J Physiol 271:C982–C993 [PMID: 8843729]PubMed
4.
Gukovskaya AS, Perkins P, Zaninovic V, Sandoval D, Rutherford R, Fitzsimmons T, Pandol SJ, Poucell-Hatton S (1996) Mechanisms of cell death after pancreatic duct obstruction in the opssum and the rat. Gastroenterology 110:875–884 [PMID: 8608898]PubMedCrossRef
5.
Kaiser AM, Saluja AK, Sengupta A, Saluja M, Steer ML (1995) Relationship between severity, necrosis, and apoptosis in five models of experimental acute pancreatitis. Am J Physiol 269:C1295–C1304 [PMID: 7491921]PubMed
6.
Yuan YZ, Gong ZH, Lou KX, Tu SP, Ju ZK, Xu JY (2000) Mechanism of somatostatin and octreotide in apoptosis of acute pancreatitis pancreatic cells. Chin Crit Care Med 12:402–405
7.
Wu ZJ, Zhang YD, Lei ZM, Yu SH (2003) Discussion on role of apoptosis in pathogenesis of rat with acute pancreatitis. China J Modern Med 13:13–15
8.
Fujimoto K, Hosotani R, Doi R, Wada M, Lee JU, Koshiba T, Miyamoto Y, Imamura M (1997) Role of neutrophils in cerulein-induced pancreatitis in rats: possible involvement of apoptosis. Digestion 58:421–430 [PMID: 9383632]PubMedCrossRef
9.
Kimura K, Shimosegawa T, Abe R, Masamune A, Satoh A, Takasu A, Koizumi M, Toyota T (1998) Low doses of lipopolysaccharide upregulate acinar apoptosis in cerulein pancreatitis. Pancreas 17:120–126 [PMID: 9700941]PubMedCrossRef
10.
Shang D, Yang PM, Xin Y, Chen HL, Liu Z (2001) Role of pancreatic acinar cell apoptosis in course of rat with acute pancreatitis and expression of apoptosis controlling gene. J Hepatopancreatobil Surg 13:152–155
11.
Hori Y, Takeyama Y, Ueda T, Shinkai M, Takase K, Kuroda Y (2000) Macrophage-derived transforming growth factor-beta1 induces hepatocellular injury via apoptosis in rat severe acute pancreatitis. Surgery 127:641–649 [PMID: 10840359]PubMedCrossRef
12.
Xu LJ, Yang C, Miao Y (2002) Role of apoptosis in intestinal mucosa barrier dysfunction of empirical acute pancreatitis rat. Hebei Med 8:577–580 [in Chinese]
13.
Zhang N (1999) Apoptosis of renal tubular cell in empirical severe acute pancreatitis. Foreign Med Surg 26:311 [in Chinese]
14.
Liu XM, Liu QG, Pang CE, Xu GF, Zhang T, Huang JY, Zhang M (2003) Influence of blood vessel endothelium apoptosis on lung injury accompanying rat with severe acute pancreatitis. J 4th Military Med Univ 24:1677–1679 [in Chinese]
15.
Chen W, Liu XL (2003) Changes of cardiac damage, myocardial Bcl-2 and Bax gene expression in severe acute pancreatitis rat and protecting effect of anisodamine. Jiangsu Med J 29:424–426 [in Chinese]
16.
Takeyama Y, Nishikawa J, Ueda T, Hori Y (1998) Thymic atrophy caused by thymocyte apoptosis in experimental severe acute pancreatitis. J Surg Res 78:97–102 [PMID: 9733625]PubMedCrossRef
17.
Wink DA, Mitchell JB (1998) Chemical biology of nitric oxide: insights into regulatory, cytotoxic, and cytoprotective mechanisms of nitric oxide. Free Radic Biol Med 25:434–456 [PMID: 9741580]PubMedCrossRef
18.
Zhang ZX, Sun JB (2001) Dual biological effect of NO and acute pancreatitis. J Capital Univ Med Sci 22:282–284 [in Chinese]
19.
Zhao M, Chen RF, Zhou YJ, Wang XC (2003) Role of endogenous NO in pathogenesis of acute hemorrhagic necrotizing pancreatitis. J Capital Univ Med Sci 24:243–246 [in Chinese]
20.
Cheng S, Zhao J, He SG, Song MM, Li ZH, Zhang YW (2003) Role of NO in lung injury of acute necrotizing pancreatitis rat. Chin J Surg 41:336–339PubMed
21.
Ren XB, He ZP, Wen L (2001) Role of NO in pancreatic and renal injury of acute hemorrhagic necrotizing pancreatitis rat. J Third Military Med Univ 23:1081–1083 [in Chinese]
22.
Tome LA, Yu L, de-Castro I, Campos SB, Seguro AC (1999) Beneficial and harmful effects of L-arginine on renal ischaemia. Nephrol Dial Transplant 14:1139–1145 [PMID: 10344352]PubMedCrossRef
23.
Werner J, Fernandez-del-Castillo C, Rivera JA, Kollias N, Lewandrowski KB, Rattner DW, Warshaw AL (1998) On the protective mechanisms of nitric oxide in acute pancreatitis. Gut 43:401–407 [PMID: 9863487]PubMedCrossRef
24.
Zhang ZX, Sun JB, Li F, Zhang SW, Cui YQ, Sun HC, Liu S (2000) Pancreatic protecting effect of endogenous NO on rat with acute necrotizing pancreatitis. Chin J Gen Surg 15:606–608
25.
Fehsel K, Kroncke KD, Meyer KL, Huber H, Wahn V, Kolb-Bachofen V (1995) Nitric oxide induces apoptosis in mouse thymocytes. J Immunol 155:2858–2865 [PMID: 7673702]PubMed
26.
Kaneto H, Fujii J, Seo HG, Suzuki K, Matsuoka T, Nakamura M, Tatsumi H, Yamasaki Y, Kamada T, Taniguchi N (1995) Apoptoic cell death triggered by nitric oxide in pancreatic β-cells. Diabetes 44:733–738 [PMID: 7540572]PubMedCrossRef
27.
Liu ML, Zhen SY, Fang XY (2001) Empirical study on NO treatment of acute necrotizing pancreatitis. J Bengbu Med Coll 26:95–96 [in Chinese]
28.
Cheng Y (2002) Role of NO-induced apoptosis in acute pancreatitis. Foreign Med Surg 29:343–346 [in Chinese]
29.
Chen K, liang J, Tang B, Ye WT, Wang WM, Zhu B (2000) Determination of serum TNF-α, IL-6 and IL-8 contents in acute pancreatitis patients. Shanghai J Immunol 20:169–171 [in Chinese]
30.
Bhatia M, Wallig MA, Hofbauer B, Lee HS, Frossard JL, Steer ML, Saluja AK (1998) Induction of apoptosis in pancreatic acinar cells reduces the severity of acute pancreatitis. Biochem Biophys Res Commun 246:476–483 [PMID: 9610387]PubMedCrossRef
31.
Yasuda H, Kataoka K, Ichimura H, Mitsuyoshi M, Iida T, Kita M, Imanishi J (1999) Cytokine expression and induction of acinar cell apoptosis after pancreatic duct ligation in mice. J Interferon Cytokine Res 19:637–644 [PMID: 10433]PubMedCrossRef
32.
Chang H, Yan JS, Wang PY, Yan JL (2002) Relation between pancreatic apoptosis and peripheral plasma TNF-α in rat acute pancreatitis. J Hepatopancreatobil Surg 14:215–216 [in Chinese]
33.
Zhang YH, Zhou L, Huang LM (2004) Role of apoptosis and TNF in pathogenesis of rat acute pancreatitis. Guizhou Med 28:1081–1083
34.
Malka D, Vasseur S, Bodeker H, Ortiz EM, Dusetti NJ, Verrando P, Dagorn JC, Iovanna JL (2000) Tumor necrosis factor alpha triggers antiapoptotic mechanisms in rat pancreatic cells through pancreatitis-associated protein activation. Gastroenterology 119:816–828 [PMID: 10982776]PubMedCrossRef
35.
Zhang G, Xiu RL, liu Z, Yang X, Tong WS, Zhang ZD, Qiao AY (2003) Preliminary discussion on lung cell apoptosis status in empirical acute pancreatitis and its meaning. China J Modern Med 13:10–13
36.
Zhang G, Zhang ZD, Xiu RL (2000) Relation between TNF-α gene expression and apoptosis and acute pancreatitis complicated with lung injury. Chin J Surg 38:671
37.
Zhang G, Xiu RL, Yang X, Liu Z, Zhang ZD, Liu XB (2002) Empirical study on relation between TNF-α gene expression and apoptosis and acute pancreatitis complicated with lung injury. Zhonghua Xiaohua Zazhi 22:22–25 [in Chinese]
38.
Satoh A, Gukovskaya AS, Edderkaoui M, Daghighian MS, Reeve JR Jr, Shimosegawa T, Pandol SJ (2005) Tumor necrosis factor-alpha mediates pancreatitis responses in acinar cells via protein kinase C and proline-rich tyrosine kinase 2. Gastroenterology 129:639–651 [PMID: 16083718]PubMedCrossRef
39.
Hori Y, Takeyama Y, Ueda T, Shinkai M, Takase K, Kuroda Y (2000) Macrophage-derived transforming growth factor-beta1 induces hepatocellular injury via apoptosis in rat severe acute pancreatitis. Surgery 127:641–649 [PMID: 10840359]PubMedCrossRef
40.
Li HY, Chen RF, Liu GZ, Wang Y, Wang XC (2004) Hepatic transforming growth factor β1 and hepatic cell apoptosis in empirical acute hemorrhagic necrotizing pancreatitis. Chin J Pathophysiol 20:1256–1260
41.
Takeyama Y, Hori Y, Takase K, Ueda T, Yamamoto M, Kuroda Y (2000) Apoptotic cell death of hepatocytes in rat experimental severe acute pancreatitis. Surgery 127:55–64 [PMID: 10660759]PubMedCrossRef
42.
Nagashio Y, Ueno H, Imamura M, Asaumi H, Watanabe S, Yamaguchi T, Taguchi M, Tashiro M, Otsuki M (2004) Inhibition of transforming growth factor beta decreases pancreatic fibrosis and protects the pancreas against chronic injury in mice. Lab Invest 84:1610–1618 [PMID: 15502860]PubMedCrossRef
43.
Subramaniam M, Harris SA, Oursler MJ, Rasmussen K, Riggs BL, Spelsberg TC (1995) Identification of a novel TGF-beta-regulated gene encoding a putative zinc finger protein in human osteoblasts. Nucleic Acids Res 23:4907–4912 [PMID: 8532536]PubMedCrossRef
44.
Tachibana I, Imoto M, Adjei PN, Gores GJ, Subramaniam M, Spelsberg TC, Urrutia R (1997) Overexpression of the TGFβ-regulated zinc finger encoding gene, TIEG, induces apoptosis in pancreatic epithelial cells. J Clin Invest 99:2365–2374 [PMID:9153278]PubMed
45.
Xu GF, Liu QG, Liu XM, Zhang T (2003) Study on apoptosis of rat severe acute pancreatitis. J 4th Military Med Univ 24:908–910 [in Chinese]
46.
Rongione AJ, Kusske AM, kwan K, Ashley SW, Reber HA, McFadden DW (1997) Interleukin 10 reduces the severity of acute pancreatitis in rats. Gastroenterology 112:960–967 [PMID: 9041259]PubMedCrossRef
47.
Gu JC, Wang Y, Zhang ZT, Xue JG, Li JS, Zhou YZ (2004) Influence of exogenous interleukin-10 on expression of hepatic Bcl-2, Bax and hepatic cell apoptosis in acute hemorrhagic necrotizing pancreatitis rat. Chin J Hepatobil Surg 10:260–262
48.
Zhang HJ, Wang X (2004) Study on protecting effect of interleukin 10 in severe acute pancreatitis. J Shanxi Med Univ 35:327–330 [in Chinese]
49.
Li YY, Gao JF (2001) Acute pancreatitis and NF-κB. Shijie Huaren Xiaohua Zazhi 9:420–421 [in Chinese]
50.
Suk K, Yeou Kim S, Kim H (2001) Regulation of IL-8 production by IFN gamma and PGE2 in mouse microglial cells: involvement of NF-κB pathway in the regulatory processes. Immunol Lett 77:79–85 [PMID: 11377701]PubMedCrossRef
51.
Izumi T, Saito Y, Kishimoto I, Harada M, Kuwahara K, Hamanaka I, Takahashi N, Kawakami R, Li Y, Takemura G, Fujiwara H, Garbers DL, Mochizuki S, Nakao K (2001) Blockade of the natriuretic peptide receptor guanylyl cyclase-A inhibits NF-kappaB activation and alleviates myocardial ischemia/reperfusion injury. J Clin Invest 108:203–213 [PMID: 11457873]PubMedCrossRef
52.
Antonelli A, Bianchi M, Crinelli R, Gentilini L, Magnani M (2001) Modulation of ICAM-1 expression in ECV304 cells by macrophage-released cytokines. Blood Cell Mol Dis 27:978–991 [PMID: 11831864]CrossRef
53.
Ginis I, Jaiswal R, Klimanis D, Liu J, Greenspon J, Hallenbeck JM (2002) TNF-alpha-induced tolerance to ischemic injury involves differential control of NF-kappaB transactivation: the role of NF-kappaB association with p300 adaptor. J Cereb Blood Flow Metab 22:142–152 [PMID: 11823712]PubMedCrossRef
54.
Wright G, Singh IS, Hasday JD, Farrance IK, Hall G, Gross AS, Roger TB (2002) Endotoxin stress-response in cardiomyocytes: NF-kappaB activation and tumor necrosis factor-alpha expression. Am J Physiol Heart Circ Physiol 282:872–879 [PMID: 11834481]
55.
Dunn JA, Li C, Ha T, Kao RL, Browder W (1997) Therapeutic modification of nuclear factor kappa B binding activity and tumor necrosis factor-alpha gene expression during acure biliary pancreatitis. Am Surg 63:1036–1043 [PMID: 9393250]PubMed
56.
Gukovsky I, Gukovskaya AS, Blinman TA, Zaninovic V, Pandol SJ (1998) Early NF-kappa B activation is associated with hormone-induced pancreatitis. Am J Physiol 275:G1402–G1414 [PMID: 984377]PubMed
57.
Bai XW, Sun B (2004) Severe acute pancreatitis and nuclear factor. J Harbin Med Univ 38:488–489 [in Chinese]
58.
Pei HH, Yang ZA, Qin ZY, Feng YQ (2002) Significance of NF-κB expression in rat with acute necrotizing pancreatitis. Chin J Gen Surg 17:752
59.
Pei HH, Yang ZA, Qin ZY, Feng YQ (2002) Significance of NF-κB expression in two kinds of empirical pancreatitis. Chin J Crit Care Med 22:72–73
60.
Satoh A, Shimosegawa T, Fujita M (1999) Inhibition of nuclear factor-kB activation improves the survival of rats with taurocholate pancreatitis. Gut 44:253–258 [PMID: 9895386]PubMedCrossRef
61.
Shi L, Tian FZ, Huang DR (2003) Hepatic NF-κB’s regulation of ICAM-1 expression and its significance in acute pancreatitis rat. Shijie Huaren Xiaohua Zazhi 11:1505–1507 [in Chinese]
62.
Gukovskaya AS, Gukovsky I, Zaninovic V, Song M, Sandoval D, Gukovsky S, Pandol SJ (1997) Pancreatic acinar cells produce, release and respond to tumor necrosis factor-alpha. Role in regulating cell death and pancreatitis. J Clin Invest 100:1853–1862 [PMID: 9312187]PubMedCrossRef
63.
Weber CK, Adler G (2001) From acinar cell damage to systemic inflammatory response: current concepts inpancreatitis. Pancreatology 1:356–362 [PMID: 12120214]PubMedCrossRef
64.
Haddad JJ, Land SC (2000) The differential expression of apoptosis factors in the alveolar epithelium is redox sensitive and requires NF-kappaB (RelA)-selective targeting. Biochem Biophys Res Commun 271:257–267 [PMID: 10777712]PubMedCrossRef
65.
Wang CY, Guttridge DC, Mayo MW, Baldwin AS (1999) NF-kappaB induces expression of the Bcl-2 homologue A1/Bfl-1 to preferentially suppress chemotherapy-induced apoptosis. Mol Cell Biol 19:5923–5929 [PMID: 10454539]PubMed
66.
Zhen JS (2002) Study progress on death methods of nuclear factor and acinar cell. Chin J Gastroenterol Hepatol 11:284–287 [in Chinese]
67.
Sandoval D, Gukovskaya A, Reavey P, Gukovsky S, Sisk A, Braquet P, Pandol SJ, Poucell-Hatton S (1996) The role of neutrophilis and platelet-activating factor in mediating experimental pancreatitis. Gastroenterology 111:1081–1091 [PMID: 8831604]PubMedCrossRef
68.
Wang XP, Wang BX, Wu K, Xu XF (2001) Role of apoptosis in early intestinal mucosa epithelial cell death of acute necrotizing pancreatitis. Zhonghua Xiaohua Zazhi 21:267–270 [in Chinese]
69.
Norman JG, Fink G, Franz M, Guffey J, Carter G, Davison B, Sexton C, Glaccum M (1996) Active interleukin-1 receptor required for maximal progression of acute pancreatitis. Ann Surg 223:163–169 [PMID: 8597510]PubMedCrossRef
70.
Fink GW, Norman JG (1996) Intrapancreatic interleukin-1beta gene expression by specific l eukocyte populations during acute pancreatitis. J Surg Res 63:369–373 [PMID: 8661228]PubMedCrossRef
71.
Rau B, Paszkowski A, Lillich S, Baumgart K, Moller P, Beger HG (2001) Differential effects of caspase-1/interleukin-1 beta-converting enzyme on acinar cell necrosis and apoptosis in severe acute experimental pancreatitis. Lab Invest 81:1001–1013 [PMID: 11454989]PubMed
72.
Yu SH, Lei ZM, Zhang PM, Gao JY (2002) Dynamic changes of cytokines and pancreatic acinar cell apoptosis in acute stage of severe acute pancreatitis acute. Chongqing Med J 31:970–972 [in Chinese]
73.
Yu SH, Lei ZM, Zhang PM, Chen YB (2003) Influence of emodin on TNF-α, IL-6 and pancreatic acinar cell apoptosis of rat severe pancreatitis. Chinese J Integr Tradit West Med 9:209–211
74.
Zhu WM, Li JS (2000) Relations among severe acute pancreatitis, inflammatory cytokines and inflammatory mediators. J Med Postgrad 13:106–109 [in Chinese]
Metadaten
Titel
Progress of Study on the Relationship Between Mediators of Inflammation and Apoptosis in Acute Pancreatitis
verfasst von
Xi-Ping Zhang
Qian Lin
Yi-Feng Zhou
Publikationsdatum
01.05.2007
Erschienen in
Digestive Diseases and Sciences / Ausgabe 5/2007
Print ISSN: 0163-2116
Elektronische ISSN: 1573-2568
DOI
https://doi.org/10.1007/s10620-006-9388-6

Weitere Artikel der Ausgabe 5/2007

Digestive Diseases and Sciences 5/2007 Zur Ausgabe

ORIGINAL PAPER

Haptoglobin Polymorphisms Are Associated with Crohn’s Disease, Disease Behavior, and Extraintestinal Manifestations in Hungarian Patients

Original Article

Lactobacillus rhamnosus GG Exacerbates Intestinal Ulceration in a Model of Indomethacin-Induced Enteropathy

Case Report

A Case of Hyperthyroidy Developing in “Pegylated-Interferon” Therapy

Original Paper

Methylenetetrahydrofolate Reductase C677T Mutation and Nonalcoholic Fatty Liver Disease

Review Paper

Fibromyxoma of the Small Bowel: A Review

Review Paper

The Sphincter of Oddi

Leitlinien kompakt für die Innere Medizin

Mit medbee Pocketcards sicher entscheiden.

Seit 2022 gehört die medbee GmbH zum Springer Medizin Verlag

Kostenlos registrieren

Neu im Fachgebiet Innere Medizin

Notfall-TEP der Hüfte ist auch bei 90-Jährigen machbar

26.04.2024 Hüft-TEP Nachrichten

Ob bei einer Notfalloperation nach Schenkelhalsfraktur eine Hemiarthroplastik oder eine totale Endoprothese (TEP) eingebaut wird, sollte nicht allein vom Alter der Patientinnen und Patienten abhängen. Auch über 90-Jährige können von der TEP profitieren.

Niedriger diastolischer Blutdruck erhöht Risiko für schwere kardiovaskuläre Komplikationen

25.04.2024 Hypotonie Nachrichten

Wenn unter einer medikamentösen Hochdrucktherapie der diastolische Blutdruck in den Keller geht, steigt das Risiko für schwere kardiovaskuläre Ereignisse: Darauf deutet eine Sekundäranalyse der SPRINT-Studie hin.

Bei schweren Reaktionen auf Insektenstiche empfiehlt sich eine spezifische Immuntherapie

25.04.2024 Allergien und Intoleranzreaktionen Nachrichten

Insektenstiche sind bei Erwachsenen die häufigsten Auslöser einer Anaphylaxie. Einen wirksamen Schutz vor schweren anaphylaktischen Reaktionen bietet die allergenspezifische Immuntherapie. Jedoch kommt sie noch viel zu selten zum Einsatz.

Therapiestart mit Blutdrucksenkern erhöht Frakturrisiko

25.04.2024 Hypertonie Nachrichten

Beginnen ältere Männer im Pflegeheim eine Antihypertensiva-Therapie, dann ist die Frakturrate in den folgenden 30 Tagen mehr als verdoppelt. Besonders häufig stürzen Demenzkranke und Männer, die erstmals Blutdrucksenker nehmen. Dafür spricht eine Analyse unter US-Veteranen.

Update Innere Medizin

Bestellen Sie unseren Fach-Newsletter und bleiben Sie gut informiert.

Newsletter bestellen
Bildnachweise