Erschienen in:
01.12.2007 | Clinical-Patient Studies
Progressive multifocal leukoencephalopathy in a patient with marginal zone B-cell lymphoma
verfasst von:
Joachim M. Baehring, Kenneth Vives, Serguei Bannykh
Erschienen in:
Journal of Neuro-Oncology
|
Ausgabe 3/2007
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Excerpt
A 60-year-old woman complained of difficulty reading and sewing. She could only see the end of a line when attempting to read. In addition, she was noted to be driving close to the divider. Neurologic examination was remarkable for an incomplete left lower quadrantanopsia. Her deep tendon reflexes were absent. There was a fiber length-dependent sensory deficit to thermal, tactile, and vibratory stimuli. She had a history of successfully treated nodular sclerosing Hodgkin’s disease (HD) and Non-Hodgkin’s lymphoma (NHL; marginal cell type) diagnosed 29 and 2 years prior to this presentation, respectively. She had received mantle field radiation for HD. The NHL had been treated with rituximab, fludarabine, and ibritumomab tiuxetan (last dose administered 4 months prior to this presentation). She had been leukopenic for a few months but had not suffered from any opportunistic infections. She received cotrimoxazole three times per week and intravenous immunoglobulin infusions for hypogammaglobulinemia. …
