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09.09.2021 | Original Article

Progressive supranuclear palsy with marked ventricular dilatation mimicking normal pressure hydrocephalus

verfasst von: Andrea Quattrone, Alessia Sarica, Domenico La Torre, Maurizio Morelli, Alessandro Mechelli, Pier Paolo Arcuri, Aldo Quattrone

Erschienen in: Neurological Sciences | Ausgabe 3/2022

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Abstract

Background

Progressive supranuclear palsy (PSP) patients can show ventricular enlargement mimicking normal pressure hydrocephalus (NPH). The aim of this study was to distinguish PSP patients with marked ventricular dilatation (PSP-vd) from those with normal ventricular system and to evaluate the coexistence of NPH in PSP-vd patients.

Methods

One hundred three probable PSP patients, 18 definite NPH patients, and 41 control subjects were enrolled in the study. Evans index (EI) > 0.32 associated with callosal angle (CA) < 100° was used to identify PSP-vd patients. Automated ventricular volumetry (AVV) and Magnetic Resonance Hydrocephalic Index (MRHI) were performed on T1-weighted MR images to evaluate the presence of NPH in PSP-vd patients.

Results

Twelve (11.6%) out of 103 PSP patients had both abnormal EI and CA values (PSP-vd). In two of these 12 patients, AVV and MRHI values suggested PSP + NPH. In the remaining 10 PSP-vd patients, AVV and MRHI values were higher than PSP patients with normal ventricular system and controls, but lower than PSP + NPH and NPH patients, suggesting a non-hydrocephalic ventricular enlargement.

Discussion

Our study provides evidence that the combination of EI and CA biomarkers allowed to identify PSP patients with marked ventricular dilatation mimicking NPH. Only a few of these patients had PSP + NPH. Recognition of these PSP patients with enlarged ventricles can positively impact the care of this disease, helping clinicians to identify patients with PSP + NPH who could benefit from shunt procedure and avoid surgery in those with enlarged ventricles without NPH.

Höglinger GU, Respondek G, Stamelou M, Kurz C, Josephs KA, Lang AE, Mollenhauer B, Müller U, Nilsson C, Whitwell JL, Arzberger T, Englund E, Gelpi E, Giese A, Irwin DJ, Meissner WG, Pantelyat A, Rajput A, van Swieten JC, Troakes C, Antonini A, Bhatia KP, Bordelon Y, Compta Y, Corvol JC, Colosimo C, Dickson DW, Dodel R, Ferguson L, Grossman M, Kassubek J, Krismer F, Levin J, Lorenzl S, Morris HR, Nestor P, Oertel WH, Poewe W, Rabinovici G, Rowe JB, Schellenberg GD, Seppi K, van Eimeren T, Wenning GK, Boxer AL, Golbe LI, Litvan I, for the Movement Disorder Society- endorsed PSP study group (2017) Clinical diagnosis of progressive supranuclear palsy: the Movement Disorder Society criteria. Mov Disord 6:853–864 CrossRef

Kato N, Arai K, Hattori T (2003) Study of the rostral midbrain atrophy in progressive supranuclear palsy. J Neurol Sci 210:57–60CrossRef

Quattrone A, Antonini A, Vaillancourt DE, Seppi K, Ceravolo R, Strafella AP, Morelli M, Nigro S, Vescio B, Bianco MG, Vasta R, Arcuri PP, Weis L, Fiorenzato E, Biundo R, Burciu RG, Krismer F, McFarland NR, Mueller C, Gizewski ER, Cosottini M, Del Prete E, Mazzucchi S, Quattrone A (2020) A new MRI measure to early differentiate progressive supranuclear palsy from de novo Parkinson’s disease in clinical practice: an international study. Mov Disord 36(3):681–689. https://doi.org/10.1002/mds.28364CrossRefPubMedPubMedCentral

Ohara M, Hattori T, Yokota T (2020) Progressive supranuclear palsy often develops idiopathic normal pressure hydrocephalus-like MRI features. Eur J Neurol 27:1930–1936CrossRef

Quattrone A, Sarica A, La Torre D, Morelli M, Vescio B, Nigro S, Barbagallo G, Nisticò R, Salsone M, Arcuri PP, Novellino F, Bianco MG, Arabia G, Cascini G, Quattrone A (2020) Magnetic resonance imaging biomarkers distinguish normal pressure hydrocephalus from progressive supranuclear palsy. Mov Disord 35:1406–1415CrossRef

Cucca A, Biagioni MC, Sharma K, Golomb J, Gilbert RM, Di Rocco A, Fleisher JE (2018) Comorbid normal pressure hydrocephalus with parkinsonism: a clinical challenge and call for awareness. Case Rep Neurol Med 21:2513474

Lee JY, Im K, Kwon KY (2018) Parkinsonian patient with comorbid normal pressure hydrocephalus : clinical usefulness of diagnosis supported by neurological findings. Clin Neuroradiol 28:617–618CrossRef

Schott JM, Williams DR, Butterworth RJ, Janssen JC, Larner AJ, Holton JL, Rossor MN (2007) Shunt responsive progressive supranuclear palsy? Mov Disord 30:902–903CrossRef

Starr BW, Hagen MC, Espay AJ (2014) Hydrocephalic Parkinsonism: lessons from normal pressure hydrocephalus mimics. J Clin Mov Disord 29:1–2CrossRef

10.

Magdalinou NK, Ling H, Smith JD, Schott JM, Watkins LD, Lees AJ (2013) Normal pressure hydrocephalus or progressive supranuclear palsy? A clinicopathological case series. J Neurol 260:1009–1013CrossRef

11.

Espay AJ, Da Prat GA, Dwivedi AK, Rodriguez-Porcel F, Vaughan JE, Rosso M, Devoto JL, Duker AP, Masellis M, Smith CD, Mandybur GT, Merola A, A.E., Lang, (2017) Deconstructing normal pressure hydrocephalus: Ventriculomegaly as early sign of neurodegeneration. Ann Neurol 82:503–513CrossRef

12.

Mori E, Ishikawa M, Kato T, Kazui H, Miyake H, Miyajima M, Nakajima M, Hashimoto M, Kuriyama N, Tokuda T, Ishii K, Kaijima M, Hirata Y, Saito M, Arai H, Japanese Society of Normal Pressure Hydrocephalus (2012) Guidelines for management of idiopathic normal pressure hydrocephalus: second edition. Neurol Med Chir (Tokyo) 52:775–809CrossRef

13.

Litvan I, Agid Y, Calne D, Campbell G, Dubois B, Duvoisin RC, Goetz CG, Golbe LI, Grafman J, Growdon JH, Hallett M, Jankovic J, Quinn NP, Tolosa E, Zee DS (1996) Clinical research criteria for the diagnosis of progressive supranuclear palsy (Steele-Richardson-Olszewski syndrome): report of the NINDS-SPSP international workshop. Neurology 47:1–9CrossRef

14.

Williams DR, de Silva R, Paviour DC, Pittman A, Watt HC, Kilford L, Holton JL, Revesz T, Lees AJ (2005) Characteristics of two distinct clinical phenotypes in pathologically proven progressive supranuclear palsy: Richardson’s syndrome and PSP-parkinsonism. Brain 128:1247–1258CrossRef

15.

Miskin N, Patel H, Franceschi AM, Ades-Aron B, Le A, Damadian BE, Stanton C, Serulle Y, Golomb J, Gonen O, Rusinek H, George AE, Alzheimer’s disease neuroimaging initiative (2017) Diagnosis of normal-pressure hydrocephalus: use of traditional measures in the era of volumetric MR imaging. Radiology 285:197–205CrossRef

16.

Fahn S, Elton RL (1987) Unified Parkinson’s Disease Rating Scale. In: Fahn S, Marsden CD, Calne D, Goldstein M (eds) Recent developments in Parkinson’s disease. MacMillan Healthcare Information, Florham Park, pp 153–163

17.

Folstein MF, Folstein SE, McHugh PR (1975) “Mini-mental state:” A practical method for grading the cognitive state of patients for the clinician. J Psychiatr Res 12:189–198CrossRef

18.

Kubo Y, Kazui H, Yoshida T, Kito Y, Kimura N, Tokunaga H, Ogino A, Miyake H, Ishikawa M, Takeda M (2008) Validation of grading scale for evaluating symptoms of idiopathic normal-pressure hydrocephalus. Dement Geriatr Cogn Disord 25:37–45CrossRef

19.

Appollonio I, Leone M, Isella V, Piamarta F, Consoli T et al (2005) The frontal assessment battery (FAB): normative values in an Italian population sample. Neurol Sci 26:108–116. https://doi.org/10.1007/s10072-005-0443-4CrossRefPubMed

20.

Wechsler D (1981) Manual for the Wechsler Adult Intelligence Scale Revised. Psychological Corporation, New York

21.

Carlesimo GA, Caltagirone C, Gainotti G (1996) The mental deterioration battery: normative data, diagnostic reliability and qualitative analyses of cognitive impairment. The Group for the Standardization of the Mental Deterioration Battery. Eur Neurol 36:378–84. https://doi.org/10.1159/000117297CrossRefPubMed

22.

Benton AL, Varney NR, Hamsher KD (1978) Visuospatial judgment. A clinical test. Arch Neurol 35:364–367. https://doi.org/10.1001/archneur.1978.00500300038006CrossRefPubMed

23.

(1987) Italian standardization and classification of Neuropsychological tests. The Italian Group on the Neuropsychological Study of Aging. Ital J Neurol Sci Suppl 8:1–120

24.

Ishii K, Kanda T, Harada A, Miyamoto N, Kawaguchi T, Shimada K, Ohkawa S, Uemura T, Yoshikawa T, Mori E (2008) Clinical impact of the callosal angle in the diagnosis of idiopathic normal pressure hydrocephalus. Eur Radiol 18:2678–2683CrossRef

25.

Dale AM, Fischl B, Sereno MI (1999) Cortical surface-based analysis. I. Segmentation and surface reconstruction. Neuroimage 9:179–194CrossRef

26.

Ishii K, Soma T, Shimada K, Oda H, Terashima A, Kawasaki R (2013) Automatic volumetry of the cerebrospinal fluid space in idiopathic normal pressure hydrocephalus. Dement Geriatr Cogn Dis Extra 3:489–496CrossRef

27.

Marmarou A, Bergsneider M, Klinge P, Relkin N, Black PM (2005) The value of supplemental prognostic tests for the preoperative assessment of idiopathic normal-pressure hydrocephalus. Neurosurgery 57:S17-28. https://doi.org/10.1227/01.neu.0000168184.01002.60 (discussion ii-v)CrossRefPubMed

28.

Mihalj M, Dolić K, Kolić K, Ledenko V (2016) CSF tap test - Obsolete or appropriate test for predicting shunt responsiveness? A systemic review. J Neurol Sci 362:78–84. https://doi.org/10.1016/j.jns.2016.01.028CrossRefPubMed

29.

Ali F, Martin PR, Botha H, Ahlskog JE, Bower JH, Masumoto JY, Maraganore D, Hassan A, Eggers S, Boeve BF, Knopman DS, Drubach D, Petersen RC, Dunkley ED, van Gerpen J, Uitti R, Whitwell JL, Dickson DW, Josephs KA (2019) Sensitivity and specificity of diagnostic criteria for progressive supranuclear palsy. Mov Disord 34:1144–1153CrossRef

Titel: Progressive supranuclear palsy with marked ventricular dilatation mimicking normal pressure hydrocephalus
verfasst von: Andrea Quattrone
Alessia Sarica
Domenico La Torre
Maurizio Morelli
Alessandro Mechelli
Pier Paolo Arcuri
Aldo Quattrone
Publikationsdatum: 09.09.2021
Verlag: Springer International Publishing
Erschienen in: Neurological Sciences / Ausgabe 3/2022
Print ISSN: 1590-1874
Elektronische ISSN: 1590-3478
DOI: https://doi.org/10.1007/s10072-021-05594-4

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