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Journal of Assisted Reproduction and Genetics

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01.12.2010 | Assisted Reproduction Technologies

Prolonged gonadotropin stimulation is associated with decreased ART success

verfasst von: Meleen Chuang, Athena Zapantis, Martina Taylor, Sangita K. Jindal, Genevieve S. Neal-Perry, Harry J. Lieman, Alex Joel Polotsky

Erschienen in: Journal of Assisted Reproduction and Genetics | Ausgabe 12/2010

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Abstract

Purpose

To evaluate whether the duration of gonadotropin stimulation predicts the likelihood of live birth after ART.

Methods

All IVF or ICSI cycles using fresh autologous oocytes at our institution between January 2004 and December 2007 were analyzed.

Results

Out of 699 cycles resulting in oocyte retrieval, 193 produced a live birth (27.6%). Women who achieved a live birth had a significantly shorter stimulation phase (11.1 vs. 11.5 days, respectively). Multivariable analysis suggested that 13 days or longer of stimulation decreased the likelihood of a live birth by 53% as compared to cycles that were 10–12 days long (odds ratio [OR] 0.47; 95% confidence interval [CI]: 0.30–0.75) after adjustment for female age, maximum historical FSH, total dose of gonadotropin received, oocytes retrieved, embryos transferred, antagonist suppression and PCOS diagnosis.

Conclusions

Prolonged duration of gonadotropin stimulation is an independent negative predictor of ART success in our cohort.

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Titel: Prolonged gonadotropin stimulation is associated with decreased ART success
verfasst von: Meleen Chuang
Athena Zapantis
Martina Taylor
Sangita K. Jindal
Genevieve S. Neal-Perry
Harry J. Lieman
Alex Joel Polotsky
Publikationsdatum: 01.12.2010
Verlag: Springer US
Erschienen in: Journal of Assisted Reproduction and Genetics / Ausgabe 12/2010
Print ISSN: 1058-0468
Elektronische ISSN: 1573-7330
DOI: https://doi.org/10.1007/s10815-010-9476-6

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