Propylthiouracil/thiamazole

Excerpt

In a study, a 48-year-old woman with Graves' disease with hyperthyroidism commenced treatment with thiamazole.* After 3 weeks of treatment, she developed a skin rash [outcome not stated]. Thiamazole was switched to propylthiouracil,* which was continued for 6 years without complications. After 6 years, she developed vasculitis with ulcerations on her earlobes and nose. She tested positive for myeloperoxidase (MPO)-ANCA. Propylthiouracil was discontinued and prednisone was administered. Her vasculitis resolved and MPO-ANCA became negative. She remained euthyroid after 4 years' follow-up without medication. …