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Current Allergy and Asthma Reports
Erschienen in: Current Allergy and Asthma Reports 8/2016

01.07.2016 | Immunologic/Diagnostic Tests in Allergy (M Chapman and A Pomés, Section Editors)

Pros and Cons of Clinical Basophil Testing (BAT)

verfasst von: Hans Jürgen Hoffmann, Edward F. Knol, Martha Ferrer, Lina Mayorga, Vito Sabato, Alexandra F. Santos, Bernadette Eberlein, Anna Nopp, Donald MacGlashan

Erschienen in: Current Allergy and Asthma Reports | Ausgabe 8/2016

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Abstract

Purpose of Review

We review basophil testing by flow cytometry with an emphasis on advantages and disadvantages.

Recent Findings

There are many tools available to assess the presence and severity of allergic diseases in patients. For 50 years, peripheral blood basophils have been used as tools to study these diseases. It is a very accessible cell that binds IgE antibody and secretes the classical mediators responsible for the symptoms of allergic reactions. In the last decade, an even more accessible methodology, using flow cytometry, has been developed to enhance the ability to use basophils for both mechanistic and clinical diagnostics. Basophil testing has been included in diagnostics for different forms of allergies as well as to monitor disease status.

Summary

A variety of studies have begun to establish both precise methods and their clinical relevance for disease diagnosis, but there remain some important questions on how to take optimal advantage of the behaviours of basophils.
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Metadaten
Titel
Pros and Cons of Clinical Basophil Testing (BAT)
verfasst von
Hans Jürgen Hoffmann
Edward F. Knol
Martha Ferrer
Lina Mayorga
Vito Sabato
Alexandra F. Santos
Bernadette Eberlein
Anna Nopp
Donald MacGlashan
Publikationsdatum
01.07.2016
Verlag
Springer US
Erschienen in
Current Allergy and Asthma Reports / Ausgabe 8/2016
Print ISSN: 1529-7322
Elektronische ISSN: 1534-6315
DOI
https://doi.org/10.1007/s11882-016-0633-6

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