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Journal of Cancer Research and Clinical Oncology

Erschienen in:

10.08.2019 | Review – Cancer Research

Protective effect of the “food-microorganism-SCFAs” axis on colorectal cancer: from basic research to practical application

verfasst von: Han Shuwen, Da Miao, Qi Quan, Wu Wei, Zhang Zhongshan, Zhang Chun, Yang Xi

Erschienen in: Journal of Cancer Research and Clinical Oncology | Ausgabe 9/2019

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Abstracts

Background

Recent studies have shown that the short-chain fatty acids (SCFAs) produced by the gut microbiota play a positive role in the development of colorectal cancer (CRC).

Aims

This study aims to elucidate the “food-microorganism-SCFAs” axis and to provide guidance for prevention and intervention in CRC.

Methods

The PubMed, Embase and Cochrane databases were searched from their inceptions to August 2018, and 75 articles and 25 conference abstracts were included and analysed after identification and screening.

Results

The concentrations of SCFAs in CRC patients and individuals with a high risk of CRC were higher than those in healthy individuals. The protective mechanism of SCFAs against CRC has been described in three aspects: epigenetics, immunology and molecular signalling pathways. Many food and plant extracts that were fermented by microorganisms produced SCFAs that play positive roles with preventive and therapeutic effects on CRC. The “food-microorganism-SCFAs” axis was constructed by summarizing the pertinent literature.

Conclusions

This study provides insight into the basic research and practical application of SCFAs by assessing the protective effect of SCFAs on CRC.

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Titel: Protective effect of the “food-microorganism-SCFAs” axis on colorectal cancer: from basic research to practical application
verfasst von: Han Shuwen
Da Miao
Qi Quan
Wu Wei
Zhang Zhongshan
Zhang Chun
Yang Xi
Publikationsdatum: 10.08.2019
Verlag: Springer Berlin Heidelberg
Erschienen in: Journal of Cancer Research and Clinical Oncology / Ausgabe 9/2019
Print ISSN: 0171-5216
Elektronische ISSN: 1432-1335
DOI: https://doi.org/10.1007/s00432-019-02997-x

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