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10.08.2019 | Review – Cancer Research | Ausgabe 9/2019

Journal of Cancer Research and Clinical Oncology 9/2019

Protective effect of the “food-microorganism-SCFAs” axis on colorectal cancer: from basic research to practical application

Zeitschrift:
Journal of Cancer Research and Clinical Oncology > Ausgabe 9/2019
Autoren:
Han Shuwen, Da Miao, Qi Quan, Wu Wei, Zhang Zhongshan, Zhang Chun, Yang Xi
Wichtige Hinweise

Electronic supplementary material

The online version of this article (https://​doi.​org/​10.​1007/​s00432-019-02997-x) contains supplementary material, which is available to authorized users.

Publisher's Note

Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.

Abstracts

Background

Recent studies have shown that the short-chain fatty acids (SCFAs) produced by the gut microbiota play a positive role in the development of colorectal cancer (CRC).

Aims

This study aims to elucidate the “food-microorganism-SCFAs” axis and to provide guidance for prevention and intervention in CRC.

Methods

The PubMed, Embase and Cochrane databases were searched from their inceptions to August 2018, and 75 articles and 25 conference abstracts were included and analysed after identification and screening.

Results

The concentrations of SCFAs in CRC patients and individuals with a high risk of CRC were higher than those in healthy individuals. The protective mechanism of SCFAs against CRC has been described in three aspects: epigenetics, immunology and molecular signalling pathways. Many food and plant extracts that were fermented by microorganisms produced SCFAs that play positive roles with preventive and therapeutic effects on CRC. The “food-microorganism-SCFAs” axis was constructed by summarizing the pertinent literature.

Conclusions

This study provides insight into the basic research and practical application of SCFAs by assessing the protective effect of SCFAs on CRC.

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Zusatzmaterial
Supplementary material 1 (DOC 23 kb)
432_2019_2997_MOESM1_ESM.doc
Supplementary material 2 (DOC 24 kb)
432_2019_2997_MOESM2_ESM.doc
Supplementary material 3 (DOC 22 kb)
432_2019_2997_MOESM3_ESM.doc
Supplementary material 4 (DOC 21 kb)
432_2019_2997_MOESM4_ESM.doc
Supplementary material 5 (DOC 33 kb)
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Supplementary material 6 (DOC 31 kb)
432_2019_2997_MOESM6_ESM.doc
Literatur
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