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Immunologic Research
Erschienen in: Immunologic Research 4/2016

24.05.2016 | Review

Protein tyrosine phosphatase SHP-1: resurgence as new drug target for human autoimmune disorders

verfasst von: Yadhu Sharma, Samina Bashir, Puja Bhardwaj, Altaf Ahmad, Farah Khan

Erschienen in: Immunologic Research | Ausgabe 4/2016

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Abstract

Recognition of self-antigen and its destruction by the immune system is the hallmark of autoimmune diseases. During the developmental stages, immune cells are introduced to the self-antigen, for which tolerance develops. The inflammatory insults that break the immune tolerance provoke immune system against self-antigen, progressively leading to autoimmune diseases. SH2 domain containing protein tyrosine phosphatase (PTP), SHP-1, was identified as hematopoietic cell-specific PTP that regulates immune function from developing immune tolerance to mediating cell signaling post-immunoreceptor activation. The extensive research on SHP-1-deficient mice elucidated the diversified role of SHP-1 in immune regulation, and inflammatory process and related disorders such as cancer, autoimmunity, and neurodegenerative diseases. The present review focalizes upon the implication of SHP-1 in the pathogenesis of autoimmune disorders, such as allergic asthma, neutrophilic dermatosis, atopic dermatitis, rheumatoid arthritis, and multiple sclerosis, so as to lay the background in pursuance of developing therapeutic strategies targeting SHP-1. Also, new SHP-1 molecular targets have been suggested like SIRP-α, PIPKIγ, and RIP-1 that may prove to be the focal point for the development of therapeutic strategies.
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Metadaten
Titel
Protein tyrosine phosphatase SHP-1: resurgence as new drug target for human autoimmune disorders
verfasst von
Yadhu Sharma
Samina Bashir
Puja Bhardwaj
Altaf Ahmad
Farah Khan
Publikationsdatum
24.05.2016
Verlag
Springer US
Erschienen in
Immunologic Research / Ausgabe 4/2016
Print ISSN: 0257-277X
Elektronische ISSN: 1559-0755
DOI
https://doi.org/10.1007/s12026-016-8805-y

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