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American Journal of Clinical Dermatology
Erschienen in: American Journal of Clinical Dermatology 6/2015

01.12.2015 | Review Article

Prurigo Pigmentosa: Literature Review

verfasst von: Bryce D. Beutler, Philip R. Cohen, Robert A. Lee

Erschienen in: American Journal of Clinical Dermatology | Ausgabe 6/2015

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Abstract

Prurigo pigmentosa, also referred to as Nagashima’s disease, is a rare inflammatory skin condition of unknown etiology. It typically presents as pruritic erythematous papules, papulovesicles, and vesicles appearing in a reticular pattern on the back, chest, or neck. The histological features of prurigo pigmentosa vary according to the stage of the disease. Early-stage disease is characterized by a superficial perivascular infiltrate of neutrophils; spongiosis and necrotic keratinocytes commonly appear in later stages. The etiology of prurigo pigmentosa has yet to be determined. Oral minocycline is usually the first-line therapy for prurigo pigmentosa. However, doxycycline, macrolide antibiotics, and/or dapsone (diaminodiphenyl sulfone) may be indicated for some patients. We describe the key features of prurigo pigmentosa, including the epidemiology, clinical and histologic presentation, differential diagnosis, postulated pathogenesis, and treatment options for this condition.
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Metadaten
Titel
Prurigo Pigmentosa: Literature Review
verfasst von
Bryce D. Beutler
Philip R. Cohen
Robert A. Lee
Publikationsdatum
01.12.2015
Verlag
Springer International Publishing
Erschienen in
American Journal of Clinical Dermatology / Ausgabe 6/2015
Print ISSN: 1175-0561
Elektronische ISSN: 1179-1888
DOI
https://doi.org/10.1007/s40257-015-0154-4

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