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2021 | OriginalPaper | Buchkapitel

39. Psychopharmaka

verfasst von : Prof. Dr. med. Martin J. Lohse, Dr. med. Johanna Seifert, Prof. Dr. med. Stefan Bleich

Erschienen in: Arzneiverordnungs-Report 2021

Verlag: Springer Berlin Heidelberg

Zusammenfassung

Auf einen Blick

Zusammenfassung Mit weit über 2 Milliarden DDD stellen die Psychopharmaka eine der größten Arzneimittelgruppen dar. Dabei sind die seit vielen Jahren beobachteten Zuwächse vor allem auf steigende Verordnungen und Indikationsausweitungen von Antidepressiva zurückzuführen sowie geringere Zunahmen bei den Neuroleptika (Antipsychotika). Dagegen nehmen die Verordnungen von Arzneimitteln mit sedierender und anxiolytischer Wirkung (Tranquillantien) seit langem kontinuierlich ab.
Trend Im Durchschnitt haben die Verordnungen von Antidepressiva (Noradrenalin/Serotonin-Verstärker) in der letzten Dekade um mehr als 40 % zugenommen. Dieser Anstieg wurde vor allem von den selektiven Serotonin-Rückaufnahme-Inhibitoren (SSRI) und den selektiven Serotonin-Noradrenalin-Rückaufnahme-Inhibitoren (SNRI) getragen, während die älteren nichtselektiven Monoamin-Rückaufnahme-Inhibitoren (NSMRI, sog. trizyklischen oder heterozyklischen Antidepressiva) seit 2010 in ihrer Verordnung rückläufig waren.
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Zurück zum Zitat Jans T, Warnke A (2010) Die britische NICE-Guidance zu Diagnose und Therapie der Aufmerksamkeitsdefizit-/Hyperaktivitätsstörung (ADHS) im Kindes-, Jugend- und Erwachsenenalter. Arzneiverordn Prax 37:4–6 Jans T, Warnke A (2010) Die britische NICE-Guidance zu Diagnose und Therapie der Aufmerksamkeitsdefizit-/Hyperaktivitätsstörung (ADHS) im Kindes-, Jugend- und Erwachsenenalter. Arzneiverordn Prax 37:4–6
Zurück zum Zitat Kane JM, Carson WH, Saha AR, McQuade RD, Ingenito GG, Zimbroff DL, Ali MW (2002) Efficacy and safety of aripiprazole and haloperidol versus placebo in patients with schizophrenia and schizoaffective disorder. J Clin Psychiatry 63:763–771PubMed Kane JM, Carson WH, Saha AR, McQuade RD, Ingenito GG, Zimbroff DL, Ali MW (2002) Efficacy and safety of aripiprazole and haloperidol versus placebo in patients with schizophrenia and schizoaffective disorder. J Clin Psychiatry 63:763–771PubMed
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Zurück zum Zitat National Institute for Health and Care Excellence (2014) Psychosis and schizophrenia in adults: prevention and management. Clinical guideline. nice.org.uk/guidance/cg178 National Institute for Health and Care Excellence (2014) Psychosis and schizophrenia in adults: prevention and management. Clinical guideline. nice.org.uk/guidance/cg178
Zurück zum Zitat Németh G, Laszlovszky I, Czobor P, Szalai E, Szatmári B, Harsányi J, Barabássy Á, Debelle M, Durgam S, Bitter I, Marder S, Fleischhacker WW (2017) Cariprazine versus risperidone monotherapy for treatment of predominant negative symptoms in patients with schizophrenia: a randomised, double-blind, controlled trial. Lancet 389:1103–1113PubMed Németh G, Laszlovszky I, Czobor P, Szalai E, Szatmári B, Harsányi J, Barabássy Á, Debelle M, Durgam S, Bitter I, Marder S, Fleischhacker WW (2017) Cariprazine versus risperidone monotherapy for treatment of predominant negative symptoms in patients with schizophrenia: a randomised, double-blind, controlled trial. Lancet 389:1103–1113PubMed
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Zurück zum Zitat Nicolussi S, Drewe J, Butterweck V, Meyer Zu Schwabedissen HE (2020) Clinical relevance of St. John’s wort drug interactions revisited. Br J Pharmacol 177:1212–1226PubMedPubMedCentral Nicolussi S, Drewe J, Butterweck V, Meyer Zu Schwabedissen HE (2020) Clinical relevance of St. John’s wort drug interactions revisited. Br J Pharmacol 177:1212–1226PubMedPubMedCentral
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Zurück zum Zitat Remschmidt H, Working Group (2005) Global consensus on ADHD/HKD. Eur Child Adolesc Psychiatry 14:127–137PubMed Remschmidt H, Working Group (2005) Global consensus on ADHD/HKD. Eur Child Adolesc Psychiatry 14:127–137PubMed
Zurück zum Zitat Rosenberg PB, Drye LT, Martin BK, Frangakis C, Mintzer JE, Weintraub D, Porsteinsson AP, Schneider LS, Rabins PV, Munro CA, Meinert CL, Lyketsos CG, DIADS-2 Research Group (2010) Sertraline for the treatment of depression in Alzheimer disease. Am J Geriatr Psychiatry 18:136–145PubMedPubMedCentral Rosenberg PB, Drye LT, Martin BK, Frangakis C, Mintzer JE, Weintraub D, Porsteinsson AP, Schneider LS, Rabins PV, Munro CA, Meinert CL, Lyketsos CG, DIADS-2 Research Group (2010) Sertraline for the treatment of depression in Alzheimer disease. Am J Geriatr Psychiatry 18:136–145PubMedPubMedCentral
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Zurück zum Zitat Smith EG, Austin KL, Kim HM, Eisen SV, Kilbourne AM, Miller DR, Zivin K, Hannemann C, Sauer BC, Valenstein M (2015) Mortality associated with lithium and valproate treatment of US veterans health administration patients with mental disorders. Br J Psychiatry 207:55–63PubMed Smith EG, Austin KL, Kim HM, Eisen SV, Kilbourne AM, Miller DR, Zivin K, Hannemann C, Sauer BC, Valenstein M (2015) Mortality associated with lithium and valproate treatment of US veterans health administration patients with mental disorders. Br J Psychiatry 207:55–63PubMed
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Zurück zum Zitat Soyka M, Lieb M (2015) Recent developments in pharmacotherapy of alcoholism. Pharmacopsychiatry 48:123–135PubMed Soyka M, Lieb M (2015) Recent developments in pharmacotherapy of alcoholism. Pharmacopsychiatry 48:123–135PubMed
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Zurück zum Zitat Storebø OJ, Ramstad E, Krogh HB, Nilausen TD, Skoog M, Holmskov M, Rosendal S, Groth C, Magnusson FL, Moreira-Maia CR, Gillies D, Buch Rasmussen K, Gauci D, Zwi M, Kirubakaran R, Forsbøl B, Simonsen E, Gluud C (2015) Methylphenidate for children and adolescents with attention deficit hyperactivity disorder (ADHD). Cochrane Database Syst Rev. https://doi.org/10.1002/14651858.CD009885.pub2 CrossRefPubMed Storebø OJ, Ramstad E, Krogh HB, Nilausen TD, Skoog M, Holmskov M, Rosendal S, Groth C, Magnusson FL, Moreira-Maia CR, Gillies D, Buch Rasmussen K, Gauci D, Zwi M, Kirubakaran R, Forsbøl B, Simonsen E, Gluud C (2015) Methylphenidate for children and adolescents with attention deficit hyperactivity disorder (ADHD). Cochrane Database Syst Rev. https://​doi.​org/​10.​1002/​14651858.​CD009885.​pub2 CrossRefPubMed
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Zurück zum Zitat Xu H, Zhuang X (2019) Atypical antipsychotics-induced metabolic syndrome and nonalcoholic fatty liver disease: a critical review. Neuropsychiatr Dis Treat 15:2087–2099PubMedPubMedCentral Xu H, Zhuang X (2019) Atypical antipsychotics-induced metabolic syndrome and nonalcoholic fatty liver disease: a critical review. Neuropsychiatr Dis Treat 15:2087–2099PubMedPubMedCentral
Zurück zum Zitat Yunusa I, Alsumali A, Garba AE, Regestein QR, Eguale T (2019) Assessment of reported comparative effectiveness and safety of atypical antipsychotics in the treatment of behavioral and psychological symptoms of dementia: a network meta-analysis. Jama Netw Open 2:e190828PubMedPubMedCentral Yunusa I, Alsumali A, Garba AE, Regestein QR, Eguale T (2019) Assessment of reported comparative effectiveness and safety of atypical antipsychotics in the treatment of behavioral and psychological symptoms of dementia: a network meta-analysis. Jama Netw Open 2:e190828PubMedPubMedCentral
Zurück zum Zitat Zalsman G, Hawton K, Wasserman D, van Heeringen K, Arensman E, Sarchiapone M, Carli V, Höschl C, Barzilay R, Balazs J, Purebl G, Kahn JP, Sáiz PA, Lipsicas CB, Bobes J, Cozman D, Hegerl U, Zohar J (2016) Suicide prevention strategies revisited: 10-year systematic review. Lancet Psychiatry 3:646–659PubMed Zalsman G, Hawton K, Wasserman D, van Heeringen K, Arensman E, Sarchiapone M, Carli V, Höschl C, Barzilay R, Balazs J, Purebl G, Kahn JP, Sáiz PA, Lipsicas CB, Bobes J, Cozman D, Hegerl U, Zohar J (2016) Suicide prevention strategies revisited: 10-year systematic review. Lancet Psychiatry 3:646–659PubMed
Zurück zum Zitat Zwanzger P (2016) Pharmakotherapie bei Angsterkrankungen. Fortschr Neurol Psychiatr 84:306–314PubMed Zwanzger P (2016) Pharmakotherapie bei Angsterkrankungen. Fortschr Neurol Psychiatr 84:306–314PubMed
Metadaten
Titel
Psychopharmaka
verfasst von
Prof. Dr. med. Martin J. Lohse
Dr. med. Johanna Seifert
Prof. Dr. med. Stefan Bleich
Copyright-Jahr
2021
Verlag
Springer Berlin Heidelberg
DOI
https://doi.org/10.1007/978-3-662-63825-5_39

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