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Reviews in Endocrine and Metabolic Disorders

Erschienen in:

29.12.2023

Pulling the trigger: Noncoding RNAs in white adipose tissue browning

verfasst von: Dehuan Liang, Guoping Li

Erschienen in: Reviews in Endocrine and Metabolic Disorders | Ausgabe 2/2024

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Abstract

White adipose tissue (WAT) serves as the primary site for energy storage and endocrine regulation in mammals, while brown adipose tissue (BAT) is specialized for thermogenesis and energy expenditure. The conversion of white adipocytes to brown-like fat cells, known as browning, has emerged as a promising therapeutic strategy for reversing obesity and its associated co-morbidities. Noncoding RNAs (ncRNAs) are a class of transcripts that do not encode proteins but exert regulatory functions on gene expression at various levels. Recent studies have shed light on the involvement of ncRNAs in adipose tissue development, differentiation, and function. In this review, we aim to summarize the current understanding of ncRNAs in adipose biology, with a focus on their role and intricate mechanisms in WAT browning. Also, we discuss the potential applications and challenges of ncRNA-based therapies for overweight and its metabolic disorders, so as to combat the obesity epidemic in the future.

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Titel: Pulling the trigger: Noncoding RNAs in white adipose tissue browning
verfasst von: Dehuan Liang
Guoping Li
Publikationsdatum: 29.12.2023
Verlag: Springer US
Erschienen in: Reviews in Endocrine and Metabolic Disorders / Ausgabe 2/2024
Print ISSN: 1389-9155
Elektronische ISSN: 1573-2606
DOI: https://doi.org/10.1007/s11154-023-09866-6

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